Follow-up observations of pulsating subdwarf B stars: Multisite campaigns on PG 1618+563B and PG 0048+091

We present follow-up observations of pulsating subdwarf B (sdB) stars as part of our efforts to resolve the pulsation spectra for use in asteroseismological analyses. This paper reports on multisite campaigns of the pulsating sdB stars PG 1618+563B and PG 0048+091. Data were obtained from observatories placed around the globe for coverage from all longitudes. For PG 1618+563B, our five-site campaign uncovered a dichotomy of pulsation states: Early during the campaign the amplitudes and phases (and perhaps frequencies) were quite variable while data obtained late in the campaign were able to fully resolve five stable pulsation frequencies. For PG 0048+091, our five-site campaign uncovered a plethora of frequencies with short pulsation lifetimes. We find them to have observed properties consistent with stochastically excited oscillations, an unexpected result for subdwarf B stars. We discuss our findings and their impact on subdwarf B asteroseismology.Comment: 50 pages including 17 figures and 10 tables. Accepted for publication in the Astrophysical Journa

New ecological risk indices for evaluating heavy metals contamination in aquatic sediment: A case study of the Gulf of Guinea

New indices – modified hazard quotient (m HQ) and ecological contamination index (ECI) – were developed for the evaluation of heavy metals contamination of sediment. Sequential extraction method was employed to determine the levels of cadmium (Cd), chromium (Cr), copper (Cu), nickel (Ni), and lead (Pb) in subtidal sediment samples from tropical ecosystems off the Gulf of Guinea. The results were used to assess the degree of contamination and estimate the extent of anthropogenic inputs from industrial activities. Results indicated that the concentrations of Cd, Cr, Cu, Ni and Pb ranged from 4.33 –5.67, 11.12– 28.52, 30.26–43.72, 2.02–2.60 and 162.0–190.37 mg/kg dw, respectively. The mean metal levels did not show significant variations among study sites during the wet and dry seasons. Spatial distribution and severity of sediment-associated contamination by heavy metals based on the newly developed indices (m HQ and ECI) were in good agreement with existing pollution indices and followed the descending sequence: Cd>Pb>Cu>Cr>Ni. Contamination severity index, mean hazard quotient and modified risk assessment code were also used to evaluate the sediment-heavy metal contamination, which generally indicated medium risk contamination of the investigated ecosystems. Aquatic pollution indicators (potential contamination index, ECI, hazard quotients, m HQ) revealed significant anthropogenic contamination by Cd and Pb, while Cr, Cu and Ni showed relatively low degree of contamination. Potential contamination index (PCI) generally followed the sequence Cd>Pb>Cu>Cr>Ni. A comparison of newly proposed indices with existing pollution indices revealed very good agreement. The contamination trends derived from the new indices were consistent and took into consideration site specificity, toxicity and a three-tier effect levels (threshold, mid-range and extreme effects guideline values) that support their reliability in evaluating contaminated aquatic ecosystems

Geochemical Speciation and Risk Assessment of Trace Metals in Sediments from Coastal Ecosystems off Equatorial Atlantic Ocean

The concentrations of Cd, Cr, Cu, Ni and Pb in estuarine benthic sediments were determined through multistep speciation scheme to evaluate their spatio-temporal distributions, selective fraction magnitude, degree of contamination and potential ecological risks. The results indicated that the metal fractionation percentages in the residual, oxidizable and reducible fractions are the most significant, while the exchangeable and carbonates bound trace metals are relatively low. High mobility and bioavailability was indicated for Cu, Cr and Ni, while Cd and Pb in sediments present low bioavailability for biota. Contamination factor (CFm), degree of contamination (DC), modified degree of contamination (mCd), geoaccumulation index (Igeo), risk assessment code (RAC), and potential ecological risk index (PERI) were used to assess trace metals sedimentary pollution. The results indicate a prevalent moderate to high contamination of most trace metals analyzed. The contamination ranking of trace metals based on percent contribution to DC was Cd>Pb>Cu>Cr>Ni. RAC values indicate medium risk for Cd and Ni at all studied sites during the wet and dry seasons. Cd and Pb show moderate and very high individual metal potential ecological risk, respectively, while multi-elemental potential ecological risk indices (RIs) indicate very high ecological risk in all the ecosystem

Dietary elimination of children with food protein induced gastrointestinal allergy – micronutrient adequacy with and without a hypoallergenic formula?

Background: The cornerstone for management of Food protein-induced gastrointestinal allergy (FPGIA) is dietary exclusion; however the micronutrient intake of this population has been poorly studied. We set out to determine the dietary intake of children on an elimination diet for this food allergy and hypothesised that the type of elimination diet and the presence of a hypoallergenic formula (HF) significantly impacts on micronutrient intake. Method: A prospective observational study was conducted on children diagnosed with FPIGA on an exclusion diet who completed a 3 day semi-quantitative food diary 4 weeks after commencing the diet. Nutritional intake where HF was used was compared to those without HF, with or without a vitamin and mineral supplement (VMS). Results: One-hundred-and-five food diaries were included in the data analysis: 70 boys (66.7%) with median age of 21.8 months [IQR: 10 - 67.7]. Fifty-three children (50.5%) consumed a HF and the volume of consumption was correlated to micronutrient intake. Significantly (p <0.05) more children reached their micronutrient requirements if a HF was consumed. In those without a HF, some continued not to achieve requirements in particular for vitamin D and zinc, in spite of VMS. Conclusion: This study points towards the important micronutrient contribution of a HF in children with FPIGA. Children, who are not on a HF and without a VMS, are at increased risk of low intakes in particular vitamin D and zinc. Further studies need to be performed, to assess whether dietary intake translates into actual biological deficiencies

Dynamic inundation simulation of storm water interaction between sewer system and overland flows

Copyright © 2002 Taylor & FrancisThis is the Author's Accepted Manuscript of an article published in the Journal of the Chinese Institute of Engineers (2002), available online at: http://www.tandfonline.com/10.1080/02533839.2002.9670691An improved urban inundation model, coupling a 2D non‐inertia overland flow model with a storm water management model, is adopted to simulate inundation in urban areas. The model computes, not only the overland runoff and the water overflow through manholes where surface runoff exceeds the capacity of storm sewers, but also the bidirectional flow interactions between sewers and overland runoff. The model was verified by a typhoon event in Nov. 2000, which resulted in serious inundation in the Mucha area of Taipei City. The result shows that the present model indeed improves simulation accuracy over the earlier model, and can be used to provide a more reliable flood mitigation design

Vancomycin versus Placebo for Treating Persistent Fever in Patients with Neutropenic Cancer Receiving Piperacillin-Tazobactam Monotherapy

This prospective, double-blind trial assessed whether the addition of a glycopeptide would be able to reduce the time to defervescence in neutropenic patients with cancer who had persistent fever 48-60 h after the initiation of empirical piperacillin-tazobactam monotherapy. Of 763 eligible patients, 165 with persistent fever were randomized to receive piperacillin-tazobactam therapy plus either vancomycin therapy or placebo. Defervescence was observed in 82 (95%) of 86 patients in the vancomycin group and in 73 (92%) of 79 patients in the placebo group (P = .52). The distributions of the time to defervescence were not statistically significant between the 2 groups (estimated hazard ratio, 1.03; 95% confidence interval, 0.75-1.43; P = .75). The number of additional episodes of gram-positive bacteremia and the percentage of patients for whom amphotericin B was empirically added to their therapy regimen were also similar in both groups. This study failed to demonstrate that the empirical addition of vancomycin therapy to the treatment regimen is of benefit to persistently febrile neutropenic patients with cance

Probabilistic Model-Based Safety Analysis

Model-based safety analysis approaches aim at finding critical failure combinations by analysis of models of the whole system (i.e. software, hardware, failure modes and environment). The advantage of these methods compared to traditional approaches is that the analysis of the whole system gives more precise results. Only few model-based approaches have been applied to answer quantitative questions in safety analysis, often limited to analysis of specific failure propagation models, limited types of failure modes or without system dynamics and behavior, as direct quantitative analysis is uses large amounts of computing resources. New achievements in the domain of (probabilistic) model-checking now allow for overcoming this problem. This paper shows how functional models based on synchronous parallel semantics, which can be used for system design, implementation and qualitative safety analysis, can be directly re-used for (model-based) quantitative safety analysis. Accurate modeling of different types of probabilistic failure occurrence is shown as well as accurate interpretation of the results of the analysis. This allows for reliable and expressive assessment of the safety of a system in early design stages

Cold Plasma Technology: Bactericidal Effects on Geobacillus Stearothermophilus and Bacillus Cereus Microorganisms

Introduction: Cold plasma, also known as Low Temperature Atmospheric Pressure Plasma (LTAPP) is a novel technology consisting of neutral and charged particles, including free radicals, which can be used to destroy or inactivate microorganisms. Research has been conducted regarding the effect of cold plasma on gram-positive bacteria; however, there is limited research regarding its ability to inactivate the spore-formers Geobacillus stearothermophilus and Bacillus cereus. Purpose: The purpose of this study was to determine if cold plasma inactivates G. stearothermophilus and B. cereus vegetative cells and spores. Methods: Nine hundred eighty-one samples were included in this study (762 experimental and 219 controls). Experimental samples were exposed indirectly or directly to cold plasma, before plating and incubating for 16 hours. Control samples were not exposed to cold plasma. The percentage-kill and cell number reductions were calculated from Colony Forming Units (CFU). Data were statistically analyzed at the .05 level using one-way ANOVA, Kruskal Wallis and Tukey\u27s tests. Results: There was a statistically significant difference in the inactivation of G. stearothermophilus vegetative cells receiving indirect and direct exposure (p=0.0001 and p=0.0013, respectively), as well as for B. cereus vegetative cells and spores (p=0.0001 for direct and indirect). There was no statistically significant difference in the inactivation of G. stearothermophilus spores receiving indirect exposure (p=0.7208) or direct exposure (p=0.0835). Conclusion: Results demonstrate that cold plasma exposure effectively kills G. stearothermophilus vegetative cells and B. cereus vegetative cells and spores; however, G. stearothermophilus spores were not significantly inactivated

Nutrition and lung cancer: a case control study in Iran

Background: Despite many prospective and retrospective studies about the association of dietary habit and lung cancer, the topic still remains controversial. So, this study aims to investigate the association of lung cancer with dietary factors. Method: In this study 242 lung cancer patients and their 484 matched controls on age, sex, and place of residence were enrolled between October 2002 to 2005. Trained physicians interviewed all participants with standardized questionnaires. The middle and upper third consumer groups were compared to the lower third according to the distribution in controls unless the linear trend was significant across exposure groups. Result: Conditional logistic regression was used to evaluate the association with lung cancer. In a multivariate analysis fruit (Ptrend < 0.0001), vegetable (P = 0.001) and sunflower oil (P = 0.006) remained as protective factors and rice (P = 0.008), bread (Ptrend = 0.04), liver (P = 0.004), butter (Ptrend = 0.04), white cheese (Ptrend < 0.0001), beef (Ptrend = 0.005), vegetable ghee (P < 0.0001) and, animal ghee (P = 0.015) remained as risk factors of lung cancer. Generally, we found positive trend between consumption of beef (P = 0.002), bread (P < 0.0001), and dairy products (P < 0.0001) with lung cancer. In contrast, only fruits were inversely related to lung cancer (P < 0.0001). Conclusion: It seems that vegetables, fruits, and sunflower oil could be protective factors and bread, rice, beef, liver, dairy products, vegetable ghee, and animal ghee found to be possible risk factors for the development of lung cancer in Iran