Kajian Icor Kabupaten Batanghari

Penelitian ini bertujuan untuk mengkaji bagaiamana ICOR Kabupaten BatangHari. Penghitungan ICOR berguna untuk melihat efisiensi perekonomian dalam menggunakan barang modal, kecenderungan penggunaan metode produksi padat karya atau padat modal dan melihat besarnya kebutuhan modal dalam perekonomian.Temuan yang menunjukkan bahwa ICOR sektor pertanian relatif kecil membuktikan bahwa sektor pertanian adalah sektor yang paling padat tenaga kerja diantara sektorsektor ekonomi yang ada. Sektor perdagangan, hotel, dan restoran memperlihatkan tingkat produktivitas kapital tinggi dibandingkan sektor lainnya. ICOR sektor ini pada ICOR tenggang waktu 2 tahun sebesar 0,24 Sektor. Pertambangan merupakan sector dengan nilai COR tertinggi

Analisis Sektor Basis Dalam Hubungannya Dengan Penyerapan Tenaga Kerja Di Kabupaten Batang Hari

The purpose of the study is to (1) analyze the economy sector which become basis sector with its development rates in Batang Hari Regency, (2) the correlation between the developments of basis sector with employment and to (3) analyze the policy of local government on developing that basis sector through bibliography methods on secondary PDRB data according to constant price 2000 of Batang Hari Regency and Jambi Province from 2003 to 2012 and also employment data in the same periods and regency. This analysis uses Location Quotient (LQ) model and Dynamic Location Quotient (DLQ) model. Whereas the correlation between the developments of basis sector with employment uses Pearson\u27s Coefficient Of Correlation. The output of LQ analysis shows that there are four economy sectors as basis sector (LQ >1) in Batang Hari, which are agricultures, industry and manufactures, trades, hotels, restaurants, and another distinction service. While from the DLQ analysis, there are four sectors identified can be a basis sector in the future (DLQ >1), which are mining and excavation, electricity, gases and fresh water, transportation and communications, and distinction sectors. Only distinction sector which is identified as basis sector nowadays as well as in the future. From the study of the PDRB rate in Batang Hari from 2003 to 2013 shows that average growth rate of agriculture, industry and manufactures, trades, hotels and restaurants are relatively smaller than other sectors in Batang Hari, excluding distinction sectors which are higher. Pearson\u27s Coefficient Of Correlation analysis evinces there only two basis sectors which its growth has a strong and positive correlation with employment in Batang Hari, which are distinction and trades with hotels and restaurants. The PDRB growth of these sectors moving in the direction of the employment rates. In the agriculture and manufacture industry sectors, the correlation with employment is low and very weak

Seasonal Adjustment Methods and the Determination of Turning Points of the EMU Business Cycle

In this paper, we investigate the impact of the adjustment for seasonal effects with different seasonal adjustment methods, the possible pre-treatment for calendar effects and the different order of aggregation and adjustment for the determination of the turning points of the European business cycle. The European business cycle is represented first by the GDP series (referring to the classical definition of a business cycle as fluctuations in the level of economic activity), and then by deviations from trend (which corresponds to the definition of the cycle as changing capacity utilisation). The turning points are determined using a mechanical procedure (Bry/Boschan methodology), which ensure that all series are treated alike. The comparison of turning points in the classical and growth cycles has brought the following results: 1.The order of seasonal adjustment and aggregation has only minor effects on the determined turning points of the European business cycle. 2.If the series are pretreated for calendar effects, turning points in the aggregated series can differ significantly. 3.It is not relevant whether the series were adjusted with a single method or with different methods (mixed aggregates)

Signaling via interleukin-4, receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice

Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity. In addition to causing an influx of neutrophils, macrophages, and dendritic cells (DCs) into the dermis, RA larvae induced a cascade of chemokine and cytokine secretion following in vitro culture of pinna biopsy samples. While macrophage inflammatory protein 1 and interleukin-1 (IL-1) were produced transiently within the first few days, the Th1-promoting cytokines IL-12 and IL-18 were secreted at high levels until at least day 14. Assay of C3H/HeJ mice confirmed that IL-12 secretion was not due to lipopolysaccharide contaminants binding Toll-like receptor 4. Significantly, IL-12 p40 secretion was sustained in pinnae from vaccinated mice but not in those from nonprotected infected mice. In contrast, IL-10 was produced from both vaccinated and infected mice. This cytokine regulates IL-12-associated dermal inflammation, since in vaccinated IL-10/ mice, pinna thickness was greatly increased concurrent with elevated levels of IL-12 p40. A significant number of IL-12 p40 cells were detected as emigrants from in vitro-cultured pinnae, and most were within a population of rare large granular cells that were Ia, consistent with their being antigen-presenting cells. Labeling of IL-12 cells for CD11c, CD205, CD8, CD11b, and F4/80 indicated that the majority were myeloid DCs, although a proportion were CD11c F4/80, suggesting that macrophages were an additional source of IL-12 in the skin

IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection.

Type 2 immune responses are essential in protection against intestinal helminth infections. In this study we show that IL-22, a cytokine important in defence against bacterial infections in the intestinal tract, is also a critical mediator of anti-helminth immunity. After infection with Nippostrongylus brasiliensis, a rodent hookworm, IL-22-deficient mice showed impaired worm expulsion despite normal levels of type 2 cytokine production. The impaired worm expulsion correlated with reduced goblet cell hyperplasia and reduced expression of goblet cell markers. We further confirmed our findings in a second nematode model, the murine whipworm Trichuris muris. T.muris infected IL-22-deficient mice had a similar phenotype to that seen in N.brasiliensis infection, with impaired worm expulsion and reduced goblet cell hyperplasia. Ex vivo and in vitro analysis demonstrated that IL-22 is able to directly induce the expression of several goblet cell markers, including mucins. Taken together, our findings reveal that IL-22 plays an important role in goblet cell activation, and thus, a key role in anti-helminth immunity

Chasing the genes that control resistance to gastrointestinal nematodes

The host-protective immune response to infection with gastrointestinal (GI) nematodes involves a range of interacting processes that begin with recognition of the parasite’s antigens and culminate in an inflammatory reaction in the intestinal mucosa. Precisely which immune effectors are responsible for the loss of specific worms is still not known although many candidate effectors have beenproposed. However, it is now clear that many different genes regulate the response and that differences between hosts (fast or strong versus slow or weak responses) can be explained by allelic variation in crucial genes associated with the gene cascade that accompanies the immune response and/or genes encoding constitutively expressed receptor/signalling molecules. Major histocompatibility complex (MHC) genes have been recognized for some time as decisive in controlling immunity, and evidence that non-MHC genes are equally, if not more important in this respect has also been available for two decades. Nevertheless, whilst the former have been mapped in mice, only two candidate loci have been proposed for non-MHC genes and relatively little is known about their roles. Now, with the availability of microsatellite markers, it is possible to exploit linkage mapping techniques to identify quantitative trait loci (QTL) responsible for resistance to GI nematodes. Four QTL for resistance to Heligmosomoides polygyrus, and additional QTL affecting faecal egg production by the worms and the accompanying immune responses, have been identified. Fine mapping and eventually the identification of the genes (and their alleles) underlying QTL for resistance/susceptibility will permit informed searches for homologues in domestic animals, and human beings, through comparative genomic maps. This information in turn will facilitate targeted breeding to improve resistance in domestic animals and, in human beings, focused application of treatment and control strategies for GI nematodes

Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden.

Parasitic helminth infections can be associated with lifelong morbidity such as immune-mediated organ failure. A better understanding of the host immune response to helminths could provide new avenues to promote parasite clearance and/or alleviate infection-associated morbidity. Murine resistin-like molecules (RELM) exhibit pleiotropic functions following helminth infection including modulating the host immune response; however, the relevance of human RELM proteins in helminth infection is unknown. To examine the function of human resistin (hResistin), we utilized transgenic mice expressing the human resistin gene (hRetnTg+). Following infection with the helminth Nippostrongylus brasiliensis (Nb), hResistin expression was significantly upregulated in infected tissue. Compared to control hRetnTg- mice, hRetnTg+ mice suffered from exacerbated Nb-induced inflammation characterized by weight loss and increased infiltration of inflammatory monocytes in the lung, along with elevated Nb egg burdens and delayed parasite expulsion. Genome-wide transcriptional profiling of the infected tissue revealed that hResistin promoted expression of proinflammatory cytokines and genes downstream of toll-like receptor signaling. Moreover, hResistin preferentially bound lung monocytes, and exogenous treatment of mice with recombinant hResistin promoted monocyte recruitment and proinflammatory cytokine expression. In human studies, increased serum resistin was associated with higher parasite load in individuals infected with soil-transmitted helminths or filarial nematode Wuchereria bancrofti, and was positively correlated with proinflammatory cytokines. Together, these studies identify human resistin as a detrimental factor induced by multiple helminth infections, where it promotes proinflammatory cytokines and impedes parasite clearance. Targeting the resistin/proinflammatory cytokine immune axis may provide new diagnostic or treatment strategies for helminth infection and associated immune-mediated pathology

NASA's Robotic Lunar Lander Development Program

NASA Marshall Space Flight Center and the Johns Hopkins University Applied Physics Laboratory have developed several mission concepts to place scientific and exploration payloads ranging from 10 kg to more than 200 kg on the surface of the moon. The mission concepts all use a small versatile lander that is capable of precision landing. The results to date of the lunar lander development risk reduction activities including high pressure propulsion system testing, structure and mechanism development and testing, and long cycle time battery testing will be addressed. The most visible elements of the risk reduction program are two fully autonomous lander flight test vehicles. The first utilized a high pressure cold gas system (Cold Gas Test Article) with limited flight durations while the subsequent test vehicle, known as the Warm Gas Test Article, utilizes hydrogen peroxide propellant resulting in significantly longer flight times and the ability to more fully exercise flight sensors and algorithms. The development of the Warm Gas Test Article is a system demonstration and was designed with similarity to an actual lunar lander including energy absorbing landing legs, pulsing thrusters, and flight-like software implementation. A set of outdoor flight tests to demonstrate the initial objectives of the WGTA program was completed in Nov. 2011, and will be discussed