1,751 research outputs found
The differences in local translatome across distinct neuron types is mediated by both baseline cellular differences and post-transcriptional mechanisms
Fitting a spatial-temporal rainfall model using Approximate Bayesian Computation
We fit a stochastic spatial-temporal model to high-resolution rainfall radar data for a single rainfall event. Approximate Bayesian Computation (ABC) is used to fit a model of Cox, Isham and Northrop, previously fitted using the Generalised Method of Moments (GMM). We then show that ABC readily adapts to more general, and thus more realistic, variants of the model. The Simulated Method of Moments (SMM) is used to initialise the ABC fit
Thorny Spheres and Black Holes with Strings
We consider thorny spheres, that is 2-dimensional compact surfaces which are
everywhere locally isometric to a round sphere except for a finite number
of isolated points where they have conical singularities. We use thorny spheres
to generate, from a spherically symmetric solution of the Einstein equations,
new solutions which describe spacetimes pierced by an arbitrary number of
infinitely thin cosmic strings radially directed. Each string produces an angle
deficit proportional to its tension, while the metric outside the strings is a
locally spherically symmetric solution. We prove that there can be arbitrary
configurations of strings provided that the directions of the strings obey a
certain equilibrium condition. In general this equilibrium condition can be
written as a force-balance equation for string forces defined in a flat 3-space
in which the thorny sphere is isometrically embedded, or as a constraint on the
product of holonomies around strings in an alternative 3-space that is flat
except for the strings. In the case of small string tensions, the constraint
equation has the form of a linear relation between unit vectors directed along
the string axes.Comment: 37 pages, 11 figure
Cardiovascular Risk Factors Among People being Treated for HIV in Nepal: a Cross-Sectional Study.
Background: Human Immunodeficiency Virus (HIV) and antiretroviral therapy (ART) are found to be strongly associated with cardiovascular diseases. Data are sparse on the prevalence and distribution of cardiovascular risk factors among people being treated for HIV in South Asia region. Methods: A cross-sectional study of 103 HIV patients (51 women and 52 men) attending routine follow-up consultations at the largest ART centre in Nepal was conducted. Data on several cardiovascular risk factors were collected through interview questionnaires, biophysical measurements and consulting medical records. Results: The most common cardiovascular risk factors observed were central obesity [34.6%, 95% Confidence Interval (CI): 25.3% to 43.9%], chronic kidney disease [20.7% (95% CI: 11.6% to 29.7%)] and tachycardia [20.6% (95% CI: 12.7% to 28.5%)]. Females were significantly more likely to have central obesity (male 9.8% vs. female 60%, p=0.016) and chronic kidney disease (male 15.4% vs. female 26.3%, p=0.003) as compared to the males. Participants were fairly active but a large proportion, especially men, had smoked [65% (95% CI: 57%-72.3%)], used tobacco products [66% (95% CI: 56.4%-74.4%)] or drugs (53.8% of the men) and consumed alcohol [60.2% (95% CI: 50.5%-69.1%)]. Conclusion: A high prevalence of several cardiovascular risk factors was observed among patients being treated for HIV in Nepal. Further larger studies are warranted to better understand the relevance and public health impact of cardiovascular risk factors in this region
Correlations between black holes formed in cosmic string breaking
An analysis of cosmic string breaking with the formation of black holes
attached to the ends reveals a remarkable feature: the black holes can be
correlated or uncorrelated. We find that, as a consequence, the
number-of-states enhancement factor in the action governing the formation of
uncorrelated black holes is twice the one for a correlated pair. We argue that
when an uncorrelated pair forms at the ends of the string, the physics involved
is more analogous to thermal nucleation than to particle-antiparticle creation.
Also, we analyze the process of intercommuting strings induced by black hole
annihilation and merging. Finally, we discuss the consequences for grand
unified strings. The process whereby uncorrelated black holes are formed yields
a rate which significantly improves over those previously considered, but still
not enough to modify string cosmology.Comment: 11 pages, LaTeX. Final version, to appear in Phys. Rev.
Unambiguous probabilities in an eternally inflating universe
``Constants of Nature'' and cosmological parameters may in fact be variables
related to some slowly-varying fields. In models of eternal inflation, such
fields will take different values in different parts of the universe. Here I
show how one can assign probabilities to values of the ``constants'' measured
by a typical observer. This method does not suffer from ambiguities previously
discussed in the literature.Comment: 7 pages, Final version (minor changes), to appear in Phys. Rev. Let
Univalent Foundations and the UniMath Library
We give a concise presentation of the Univalent Foundations of mathematics outlining the main ideas, followed by a discussion of the UniMath library of formalized mathematics implementing the ideas of the Univalent Foundations (section 1), and the challenges one faces in attempting to design a large-scale library of formalized mathematics (section 2). This leads us to a general discussion about the links between architecture and mathematics where a meeting of minds is revealed between architects and mathematicians (section 3). On the way our odyssey from the foundations to the "horizon" of mathematics will lead us to meet the mathematicians David Hilbert and Nicolas Bourbaki as well as the architect Christopher Alexander
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