The CLEO-c Research Program

The CLEO-c research program will include studies of leptonic, semileptonic and hadronic charm decays, searches for exotic and gluonic matter, and test for physics beyond the Standard Model. In the summer of 2003 the experiment and the CESR accelerator were modified to operate at center-of-mass energies between 3 and 5 GeV. Data at the psi(3770) resonance were recorded with the CLEO-c detector in September 2003. beginning a new era in the exploration of the charm sector.Comment: 5 pages, also available http://www.lns.cornell.edu/public/TALK/2003/, Presented at 9th International Conference on B Physics at Hadron Machines(Beauty2003), Pittsburgh, PA, Oct. 14-18, 200

Top quark precision physics at the International Linear Collider

Top quark production in the process $e^+e^- \rightarrow t\bar{t}$ at a future linear electron positron collider with polarized beams is a powerful tool to determine the scale of new physics. Studies at the \ttbar threshold will allow for precise determination of the top quark mass in a well defined theoretical framework. At higher energies vector, axial vector and tensorial CP conserving couplings can be separately determined for the photon and the $Z^0$ component in the electro-weak production process. The sensitivity to new physics would be dramatically improved w.r.t. to what expected from LHC for electroweak couplings.Comment: White paper for Snowmass CSS 201

First ADS analysis of B- -> D0K- decays in hadron collisions

Proceedings of DISCRETE 2010, Symposium on Prospects in the Physics of Discrete Symmetries, Rome (IT), 6-11 December 2010Comment: 7 pages, 5 figure

Clinical Disease Severity of Respiratory Viral Co-Infection versus Single Viral Infection: A Systematic Review and Meta-Analysis.

BACKGROUND: Results from cohort studies evaluating the severity of respiratory viral co-infections are conflicting. We conducted a systematic review and meta-analysis to assess the clinical severity of viral co-infections as compared to single viral respiratory infections. METHODS: We searched electronic databases and other sources for studies published up to January 28, 2013. We included observational studies on inpatients with respiratory illnesses comparing the clinical severity of viral co-infections to single viral infections as detected by molecular assays. The primary outcome reflecting clinical disease severity was length of hospital stay (LOS). A random-effects model was used to conduct the meta-analyses. RESULTS: Twenty-one studies involving 4,280 patients were included. The overall quality of evidence applying the GRADE approach ranged from moderate for oxygen requirements to low for all other outcomes. No significant differences in length of hospital stay (LOS) (mean difference (MD) -0.20 days, 95% CI -0.94, 0.53, p = 0.59), or mortality (RR 2.44, 95% CI 0.86, 6.91, p = 0.09) were documented in subjects with viral co-infections compared to those with a single viral infection. There was no evidence for differences in effects across age subgroups in post hoc analyses with the exception of the higher mortality in preschool children (RR 9.82, 95% CI 3.09, 31.20, p<0.001) with viral co-infection as compared to other age groups (I2 for subgroup analysis 64%, p = 0.04). CONCLUSIONS: No differences in clinical disease severity between viral co-infections and single respiratory infections were documented. The suggested increased risk of mortality observed amongst children with viral co-infections requires further investigation

Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies.

Influenza vaccination programmes are assumed to have a herd effect and protect contacts of vaccinated persons from influenza virus infection. We searched MEDLINE, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Global Health and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to March 2014 for studies assessing the protective effect of influenza vaccination vs no vaccination on influenza virus infections in contacts. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using a random-effects model. Of 43,082 screened articles, nine randomised controlled trials (RCTs) and four observational studies were eligible. Among the RCTs, no statistically significant herd effect on the occurrence of influenza in contacts could be found (OR: 0.62; 95% CI: 0.34-1.12). The one RCT conducted in a community setting, however, showed a significant effect (OR: 0.39; 95% CI: 0.26-0.57), as did the observational studies (OR: 0.57; 95% CI: 0.43-0.77). We found only a few studies that quantified the herd effect of vaccination, all studies except one were conducted in children, and the overall evidence was graded as low. The evidence is too limited to conclude in what setting(s) a herd effect may or may not be achieved