El diseño de un contrato ambiental para las explotaciones ganaderas de extensivo. Estudio aplicado a la Reserva de la Biosfera de las sierras de Béjar y Francia

publishedTomo I . Sección: Sistemas Ganaderos-Economía y Gestión. Sesión: Sostenibilidad. Ponencia nº 3

Study of Passive CMOS Mixers Effects on Image Rejection Ratio

In this brief, modeling and simulation of quadrature passive mixers are analyzed, focusing on the impact they have on the image rejection ratio (IRR). For this purpose, a 65-nm CMOS technology is used

Approaching Ideal Polyphase Filter Response in 65-nm CMOS

This work analyzes the effect of the most critical non-idealities on a passive polyphase filter implemented in a 65-nm CMOS technology, to attain single-sideband transmission in a 5 GHz Wi-Fi alike communication system. Non-idealities impact on this kind of passive complex filter have not been thoroughly analyzed in literature

Approaching Ideal Polyphase Filter Response in 65-nm CMOS

This work analyzes the effect of the most critical non-idealities on a passive polyphase filter implemented in a 65-nm CMOS technology, to attain single-sideband transmission in a 5 GHz Wi-Fi alike communication system. Non-idealities impact on this kind of passive complex filter have not been thoroughly analyzed in literature

LMTK3 confers chemo-resistance in breast cancer

Lemur tyrosine kinase 3 (LMTK3) is an oncogenic kinase that is involved in different types of cancer (breast, lung, gastric, colorectal) and biological processes including proliferation, invasion, migration, chromatin remodeling as well as innate and acquired endocrine resistance. However, the role of LMTK3 in response to cytotoxic chemotherapy has not been investigated thus far. Using both 2D and 3D tissue culture models, we found that overexpression of LMTK3 decreased the sensitivity of breast cancer cell lines to cytotoxic (doxorubicin) treatment. In a mouse model we showed that ectopic overexpression of LMTK3 decreases the efficacy of doxorubicin in reducing tumor growth. Interestingly, breast cancer cells overexpressing LMTK3 delayed the generation of double strand breaks (DSBs) after exposure to doxorubicin, as measured by the formation of γH2AX foci. This effect was at least partly mediated by decreased activity of ataxia-telangiectasia mutated kinase (ATM) as indicated by its reduced phosphorylation levels. In addition, our RNA-seq analyses showed that doxorubicin differentially regulated the expression of over 700 genes depending on LMTK3 protein expression levels. Furthermore, these genes were found to promote DNA repair, cell viability and tumorigenesis processes / pathways in LMTK3-overexpressing MCF7 cells. In human cancers, immunohistochemistry staining of LMTK3 in pre- and postchemotherapy breast tumor pairs from four separate clinical cohorts revealed a significant increase of LMTK3 following both doxorubicin and docetaxel based chemotherapy. In aggregate, our findings show for the first time a contribution of LMTK3 in cytotoxic drug resistance in breast cancer

Estimación de la degradación por mismatch del rechazo de imagen en filtros polifásicos pasivos

Los filtros polifásicos pasivos (PPF) son sistemas empleados extensivamente en transmisores o receptores heterodinos de banda lateral única (Single Side Band, SSB) para rechazar la banda imagen. Este trabajo se centra en establecer una cota a la máxima degradación que el mismatch entre componentes puede producir en su respuesta

High cooperativity coupling to nuclear spins on a circuit quantum electrodynamics architecture

Nuclear spins are candidates to encode qubits or qudits due to their isolation from magnetic noise and potentially long coherence times. However, their weak coupling to external stimuli makes them hard to integrate into circuit quantum electrodynamics architectures, the leading technology for solid-state quantum processors. Here, we study the coupling of 173Yb(III) nuclear spin states in an [Yb(trensal)] molecule to superconducting cavities. Experiments have been performed on magnetically dilute single crystals placed on the inductors of lumped-element LC superconducting resonators with characteristic frequencies spanning the range of nuclear and electronic spin transitions. We achieve a high cooperative coupling to all electronic and most nuclear [173Yb(trensal)] spin transitions, a necessary ingredient for the implementation of qudit protocols with molecular spins using a hybrid architecture

IHELP: Personalised Health Monitoring and Decision Support Based on Artificial Intelligence and Holistic Health Records

Scientific and clinical research have advanced the ability of healthcare professionals to more precisely define diseases and classify patients into different groups based on their likelihood of responding to a given treatment, and on their future risks. However, a significant gap remains between the delivery of stratified healthcare and personalization. The latter implies solutions that seek to treat each citizen as a truly unique individual, as opposed to a member of a group with whom they share common risks or health-related characteristics. Personalisation also implies an approach that takes into account personal characteristics and conditions of individuals. This paper investigates how these desirable attributes can be developed and introduces a holistic environment, the iHELP, that incorporates big data management and Artificial Intelligence (AI) approaches to enable the realization of data-driven pathways where awareness, care and decision support is provided based on person-centric early risk prediction, prevention and intervention measures