2,034 research outputs found
Deceleration of the solar wind in the Earth foreshock region: ISEE 2 and IMP 8 observations
The deceleration of the solar wind in the region of the interplanetary space filled by ions backstreaming from the Earth bow shock was studied using a two spacecraft technique. This deceleration, which is correlated with the "diffuse" but not with the "reflected" ion population, depends on the solar wind bulk velocity: at low velocities (below 300 km/sec) the velocity decrease is about 5 km/sec, while at higher velocities (above 400 km/sec) the decrease may be as large as 30 km/sec. Along with this deceleration, the solar wind undergoes a deflection of about 1 deg away from the direction of the Earth bow shock. The energy balance shows that the kinetic energy loss far exceeds the thermal energy which is possibly gained by the solar wind, therefore, at least part of this energy must go into waves and/or into the backstreaming ions
Successful private–public funding of paediatric medicines research: lessons from the EU programme to fund research into off-patent medicines
The European Paediatric Regulation mandated the European Commission to fund research on off-patent medicines with demonstrated therapeutic interest for children. Responding to this mandate, five FP7 project calls were launched and 20 projects were granted. This paper aims to detail the funded projects and their preliminary results. Publicly
available sources have been consulted and a descriptive
analysis has been performed. Twenty Research Consortia
including 246 partners in 29 European and non-European
countries were created (involving 129 universities or public funded research organisations, 51 private companies with 40 SMEs, 7 patient associations). The funded projects investigate 24 medicines, covering 10 therapeutic areas in all paediatric age groups. In response to the Paediatric Regulation and to apply for a Paediatric Use Marketing Authorisation, 15 Paediatric Investigation Plans have been granted by the EMAPaediatric Committee, including 71 studies of whom 29 paediatric clinical trials, leading to a total of 7,300 children to be recruited in more than 380 investigational centres.
Conclusion: Notwithstanding the EU contribution for each
study is lower than similar publicly funded projects, and also considering the complexity of paediatric research, these projects are performing high-quality research and are progressing towards the increase of new paediatric medicines on the market. Private–public partnerships have been effectively implemented, providing a good example for future collaborative actions. Since these projects cover a limited number of offpatent drugs and many unmet therapeutic needs in paediatrics remain, it is crucial foreseeing new similar initiatives in forthcoming European funding programmes
The Process Controller for the LHCb On-LIne Farm
The Process Controller is a tool of the LHCb FMC (Farm Monitoring and Control System) in charge of keeping a list of applications up and running on the farm nodes. It tipically runs on a few control PCs each one watching ~200 farm nodes and performs its task by maintaining the list of scheduled applications for each controlled farm node and by interacting with the Task Manager Servers running on the farm nodes to start processes, to obtain the notification of process termination, to re-spawn the terminated processes (if requested) and to stop processes. Processes can be added to or removed from the scheduled application list for one or more nodes by means of DIM commands, while DIM services provide the list of scheduled applications for each controlled farm node together with their properties, the number of re-spawns and the re-spawn times
Deep shower interpretation of the cosmic ray events observed in excess of the Greisen-Zatsepin-Kuzmin energy
We consider the possibility that the ultra-high-energy cosmic ray flux has a
small component of exotic particles which create showers much deeper in the
atmosphere than ordinary hadronic primaries. It is shown that applying the
conventional AGASA/HiRes/Auger data analysis procedures to such exotic events
results in large systematic biases in the energy spectrum measurement. SubGZK
exotic showers may be mis-reconstructed with much higher energies and mimick
superGZK events. Alternatively, superGZK exotic showers may elude detection by
conventional fluorescence analysis techniques.Comment: 22 pages, 5 figure
The Power Manager for the LHCb On-Line Farm
The Power Manager is a tool of the LHCb FMC (Farm Monitoring and Control System) which allows - in an OS-independent manner and without requiring expensive network-controlled power distributors - to switch the farm nodes on and off, and to monitor their physical condition: power status (on/off), temperatures, fan speeds and voltages. The Power Manager can operate on farm nodes whose motherboards and network interface cards implement the IPMI (Intelligent Platform Management Interface) specifications, version 1.5 or subsequent, and copes with several IPMI limitations
Effect of cosmic rays on the resonant gravitational wave detector NAUTILUS at temperature T=1.5 K
The interaction between cosmic rays and the gravitational wave bar detector
NAUTILUS is experimentally studied with the aluminum bar at temperature of
T=1.5 K. The results are compared with those obtained in the previous runs when
the bar was at T=0.14 K. The results of the run at T = 1.5 K are in agreement
with the thermo-acoustic model; no large signals at unexpected rate are
noticed, unlike the data taken in the run at T = 0.14 K. The observations
suggest a larger efficiency in the mechanism of conversion of the particle
energy into vibrational mode energy when the aluminum bar is in the
superconductive status.Comment: 7 pages, 3 figures, 2 tables. Accepted by Physics Letters
Dysprosium-carboxylate nanomeshes with tunable cavity size and assembly motif through ionic interactions
We report the design of dysprosium directed metallo-supramolecular architectures on a pristine Cu(111) surface. By an appropriate selection of the ditopic molecular linkers equipped with terminal carboxylic groups (TPA, PDA and TDA species), we create reticular and mononuclear metal–organic nanomeshes of tunable internodal distance, which are stabilized by eight-fold Dy⋯O interactions. A thermal annealing treatment for the reticular Dy:TDA architecture gives rise to an unprecedented quasi-hexagonal nanostructure based on dinuclear Dy clusters, exhibiting a unique six-fold Dy⋯O bonding motif. All metallo-supramolecular architectures are stable at room temperature. Our results open new avenues for the engineering of supramolecular architectures on surfaces incorporating f-block elements forming thermally robust nanoarchitectures through ionic bonds
Study of the coincidences between the gravitational wave detectors EXPLORER and NAUTILUS in 2001
We report the result from a search for bursts of gravitational waves using
data collected by the cryogenic resonant detectors EXPLORER and NAUTILUS during
the year 2001, for a total measuring time of 90 days. With these data we
repeated the coincidence search performed on the 1998 data (which showed a
small coincidence excess) applying data analysis algorithms based on known
physical characteristics of the detectors. With the 2001 data a new interesting
coincidence excess is found when the detectors are favorably oriented with
respect to the Galactic Disk
Long-term safety of deferiprone treatment in children from the Mediterranean region with beta-thalassaemia major: the DEEP-3 multi-centre observational safety study
Ages and Metallicities of Star Clusters and Surrounding Fields in the Outer Disk of the Large Magellanic Cloud
We present Washington system C,T_1 CMDs of 13 star clusters and their
surrounding fields which lie in the outer parts of the LMC disk. Ages are
determined by means of the magnitude difference between the giant branch clump
and the turnoff, while metallicities are derived from the location of the giant
and subgiant branches as compared to fiducial star clusters. We find that in
most cases the stellar population of each star cluster is quite similar to that
of the field where it is embedded. Three particular fields present remarkable
properties: (i) The so far unique cluster ESO121-SC03 at ~9 Gyr has a
surrounding field which shares the same properties. (ii) The field surrounding
the far eastern intermediate age cluster OHSC37 is noteworthy in the sense that
we do not detect any evidence of LMC stars. (iii) The fields of SL388 and SL509
present CMDs with a secondary clump ~0.45 mag fainter than the dominant
intermediate age clump, suggesting a stellar population component located
behind the LMC disk at a distance comparable to that of the SMC. The mean
metallicity derived for the intermediate age outer disk clusters is
=-0.7 and for their surrounding fields =-0.6. These values are
significantly lower than found by Olszewski et al. (1991, AJ, 101, 515) for a
sample of clusters of similar age, but are in good agreement with several
recent studies. A few clusters stand out in the age--metallicity relation in
the sense that they are intermediate age clusters at relatively low metallicity
([Fe/H]~-1).Comment: LaTeX, to be published in July, 1998 Astronomical Journa
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