Analysing the Transverse Structure of the Relativistic Jets of AGN

This paper describes a method of fitting total intensity and polarization profiles in VLBI images of astrophysical jets to profiles predicted by a theoretical model. As an example, the method is used to fit profiles of the jet in the Active Galactic Nucleus Mrk501 with profiles predicted by a model in which a cylindrical jet of synchrotron plasma is threaded by a magnetic field with helical and disordered components. This fitting yields model Stokes Q profiles that agree with the observed profiles to within the 1-2 \sigma uncertainties; the I model and observed profiles are overall not in such good agreement, with the model I profiles being generally more symmetrical than the observed profiles. Consistent fitting results are obtained for profiles derived from 6cm VLBI images at two distances from the core, and also for profiles obtained for different wavelengths at a single location in the VLBI jet. The most striking success of the model is its ability to reproduce the spine-sheath polarization structure observed across the jet. Using the derived viewing angle in the jet rest frame, \delta' approximately 83 degrees, together with a superluminal speed reported in the literature, \beta apparent = 3.3, yields a solution for the viewing angle and velocity of the jet in the observer's frame \delta degrees and \beta approximately 0.96. Although these results for Mrk501 must be considered tentative, the combined analysis of polarization profiles and apparent component speeds holds promise as a means of further elucidating the magnetic field structures and other parameters of parsec-scale AGN jets

A relativistic model of the radio jets in NGC 315

We apply our intrinsically symmetrical, decelerating relativistic jet model to deep VLA imaging of the inner 140 arcsec of the giant low-luminosity radio galaxy NGC 315. An optimized model accurately fits the data in both total intensity and linear polarization. We infer that the velocity, emissivity and field structure in NGC 315 are very similar to those of the other low-luminosity sources we have modelled, but that all of the physical scales are larger by a factor of about 5. We derive an inclination to the line of sight of 38 degrees for the jets. Where they first brighten, their on-axis velocity is approximately v/c = 0.9. They decelerate to v/c = 0.4 between 8 and 18 kpc from the nucleus and the velocity thereafter remains constant. The speed at the edge of the jet is roughly 0.6 of the on-axis value where it is best constrained, but the transverse velocity profile may deviate systematically from the Gaussian form we assume. The proper emissivity profile is split into three power-law regions separated by shorter transition zones. In the first of these, at 3 kpc (the flaring point) the jets expand rapidly at constant emissivity, leading to a large increase in the observed brightness on the approaching side. At 10 kpc, the emissivity drops abruptly by a factor of 2. Where the jets are well resolved their rest-frame emission is centre-brightened. The magnetic field is modelled as random on small scales but anisotropic and we rule out a globally ordered helical configuration. To a first approximation, the field evolves from a mixture of longitudinal and toroidal components to predominantly toroidal, but it also shows variations in structure along and across the jets, with a significant radial component in places. Simple adiabatic models fail to fit the emissivity variations.Comment: 20 pages, 17 figures, MNRAS (in press

The inner jet of radio galaxy NGC 315 as observed with Chandra and the VLA

We present Chandra X-ray results for the jet, nucleus, and gaseous atmosphere of NGC 315, a nearby radio galaxy whose jet kinematics are known through deep radio mapping. Diffuse X-ray synchrotron emission is detected from the jet out to 30 arcsec from the nucleus, through regions both of fast bulk flow and deceleration. The X-ray to radio flux ratio drops considerably where the flow decelerates, but the X-ray and radio emissions show similar transverse extents throughout, requiring distributed particle acceleration to maintain the supply of X-ray-emitting electrons. A remarkable knotty filament within the jet is seen in both the radio and X-ray, contributing roughly 10 per cent of the diffuse emission along its extent at both wavelengths. No completely satisfactory explanation for the filament is found, though its oscillatory appearance, roughly aligned magnetic field, and requirements for particle acceleration, suggest that it is a magnetic strand within a shear layer between fast inner and slower outer flow.Comment: Accepted for publication in the MNRAS. 13 pages,14 figures (some in colour

Patient information leaflets (PILs) for UK randomised controlled trials : a feasibility study exploring whether they contain information to support decision making about trial participation

Peer reviewedPublisher PD

An argument against the focus on Community Resilience in Public Health

Background - It has been suggested that Public Health professionals focus on community resilience in tackling chronic problems, such as poverty and deprivation; is this approach useful? Discussion - Resilience is always i) of something ii) to something iii) to an endpoint, as in i) a rubber ball, ii) to a blunt force, iii) to its original shape. “Community resilience” might be: of a neighbourhood, to a flu pandemic, with the endpoint, to return to normality. In these two examples, the endpoint is as-you-were. This is unsuitable for some examples of resilience. A child that is resilient to an abusive upbringing has an endpoint of living a happy life despite that upbringing: this is an as-you-should-be endpoint. Similarly, a chronically deprived community cannot have the endpoint of returning to chronic deprivation: so what is its endpoint? Roughly, it is an as-you-should-be endpoint: to provide an environment for inhabitants to live well. Thus resilient communities will be those that do this in the face of challenges. How can they be identified? One method uses statistical outliers, neighbourhoods that do better than would be expected on a range of outcomes given a range of stressors. This method tells us that a neighbourhood is resilient but not why it is. In response, a number of researchers have attributed characteristics to resilient communities; however, these generally fail to distinguish characteristics of a good community from those of a resilient one. Making this distinction is difficult and we have not seen it successfully done; more importantly, it is arguably unnecessary. There already exist approaches in Public Health to assessing and developing communities faced with chronic problems, typically tied to notions such as Social Capital. Communityresilience to chronic problems, if it makes sense at all, is likely to be a property that emerges from the various assets in a community such as human capital, built capital and natural capital. Summary - Public Health professionals working with deprived neighbourhoods would be better to focus on what neighbourhoods have or could develop as social capital for living well, rather than on the vague and tangential notion of community resilience.</p

Multifrequency observations of the jets in the radio galaxy NGC 315

We present images of the jets in the nearby radio galaxy NGC 315 made with the VLA at five frequencies between 1.365 and 5 GHz with resolutions between 1.5 and 45 arcsec FWHM. Within 15 arcsec of the nucleus, the spectral index of the jets is 0.61. Further from the nucleus, the spectrum is flatter, with significant transverse structure. Between 15 and 70 arcsec from the nucleus, the spectral index varies from 0.55 on-axis to 0.44 at the edge. This spectral structure suggests a change of dominant particle acceleration mechanism with distance from the nucleus and the transverse gradient may be associated with shear in the jet velocity field. Further from the nucleus, the spectral index has a constant value of 0.47. We derive the distribution of Faraday rotation over the inner +/-400 arcsec of the radio source and show that it has three components: a constant term, a linear gradient (both probably due to our Galaxy) and residual fluctuations at the level of 1 - 2 rad/m^2. These residual fluctuations are smaller in the brighter (approaching) jet, consistent with the idea that they are produced by magnetic fields in a halo of hot plasma that surrounds the radio source. We model this halo, deriving a core radius of approximately 225 arcsec and constraining its central density and magnetic-field strength. We also image the apparent magnetic-field structure over the first +/-200 arcsec from the nucleus.Comment: 20 pages, 17 figures, accepted for publication in MNRAS. Minor corrections to match published version, including a short note on emission from the background galaxy FGC011

Evaluation of inhaler technique and achievement and maintenance of mastery of budesonide/formoterol Spiromax® compared with budesonide/formoterol Turbuhaler® in adult patients with asthma: the Easy Low Instruction Over Time (ELIOT) study

Background: Incorrect inhaler technique is a common cause of poor asthma control. This two-phase pragmatic study evaluated inhaler technique mastery and maintenance of mastery with DuoResp® (budesonide-formoterol [BF]) Spiromax® compared with Symbicort® (BF) Turbuhaler® in patients with asthma who were receiving inhaled corticosteroids/long-acting β2-agonists. Methods: In the initial cross-sectional phase, patients were randomized to a 6-step training protocol with empty Spiromax and Turbuhaler devices. Patients initially demonstrating ≥1 error with their current device, and then achieving mastery with both Spiromax and Turbuhaler (absence of healthcare professional [HCP]-observed errors), were eligible for the longitudinal phase. In the longitudinal phase, patients were randomized to BF Spiromax or BF Turbuhaler. Co-primary endpoints were the proportions of patients achieving device mastery after three training steps and maintaining device mastery (defined as the absence of HCP-observed errors after 12 weeks of use). Secondary endpoints included device preference, handling error frequency, asthma control, and safety. Exploratory endpoints included assessment of device mastery by an independent external expert reviewing video recordings of a subset of patients. Results: Four hundred ninety-three patients participated in the cross-sectional phase, and 395 patients in the longitudinal phase. In the cross-sectional phase, more patients achieved device mastery after three training steps with Spiromax (94%) versus Turbuhaler (87%) (odds ratio [OR] 3.77 [95% confidence interval (CI) 2.05–6.95], p < 0.001). Longitudinal phase data indicated that the odds of maintaining inhaler mastery at 12 weeks were not statistically significantly different (OR 1.26 [95% CI 0.80–1.98], p = 0.316). Asthma control improved in both groups with no significant difference between groups (OR 0.11 [95% CI -0.09–0.30]). An exploratory analysis indicated that the odds of maintaining independent expert-verified device mastery were significantly higher for patients using Spiromax versus Turbuhaler (OR 2.11 [95% CI 1.25–3.54]). Conclusions: In the cross-sectional phase, a significantly greater proportion of patients using Spiromax versus Turbuhaler achieved device mastery; in the longitudinal phase, the proportion of patients maintaining device mastery with Spiromax versus Turbuhaler was similar. An exploratory independent expert-verified analysis found Spiromax was associated with higher levels of device mastery after 12 weeks. Asthma control was improved by treatment with both BF Spiromax and BF Turbuhaler

The physiological responses of cacao to the environment and the implications for climate change resilience. A review

Cacao (Theobroma cacao L.) is a tropical perennial crop which is of great economic importance to the confectionary industry and to the economies of many countries of the humid tropics where it is grown. Some recent studies have suggested climate change could severely impact cacao production in West Africa. It is essential to incorporate our understanding of the physiology and genetic variation within cacao germplasm when discussing the implications of climate change on cacao productivity and developing strategies for climate resilience in cacao production. Here we review the current research on the physiological responses of cacao to various climate factors. Our main findings are 1) water limitation causes significant yield reduction in cacao but genotypic variation in sensitivity is evident, 2) in the field cacao experiences higher temperatures than is often reported in the literature, 3) the complexity of the cacao/ shade tree interaction can lead to contradictory results, 4) elevated CO2 may alleviate some negative effects of climate change 5) implementation of mitigation strategies can help reduce environmental stress, 6) significant gaps in the research need addressing to accelerate the development of climate resilience. Harnessing the significant genetic variation apparent within cacao germplasm is essential to develop modern varieties capable of high yields in non-optimal conditions. Mitigation strategies will also be essential but to use shading to best effect shade tree selection is crucial to avoid resource competition. Cacao is often described as being sensitive to climate change but genetic variation, adaptive responses, appropriate mitigation strategies and interactive climate effects should all be considered when predicting the future of cacao production. Incorporating these physiological responses to various environmental conditions and developing a deeper understanding of the processes underlying these responses will help to accelerate the development of a more resource use efficient tree ensuring sustainable production into the future