Lithium in the Symbiotic Mira V407 Cyg

We report an identification of the lithium resonance doublet LiI 6708A in the spectrum of V407 Cyg, a symbiotic Mira with a pulsation period of about 745 days. The resolution of the spectra used was R~18500 and the measured equivalent width of the line is ~0.34A. It is suggested that the lithium enrichment is due to hot bottom burning in the intermediate mass AGB variable, although other possible origins cannot be totally ruled out. In contrast to lithium-rich AGB stars in the Magellanic clouds, ZrO 5551A, 6474A absorption bands were not found in the spectrum of V407Cyg. These are the bands used to classify the S-type stars at low-resolution. Although we identified weak ZrO 5718A, 6412A these are not visible in the low-resolution spectra, and we therefore classify the Mira in V407 Cyg as an M type. This, together with other published work, suggests lithium enrichment can precede the third dredge up of s-process enriched material in galactic AGB stars.Comment: 4 pages, 2 figures, to be published in MNRA

Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene

Acromegaly in humans is usually sporadic, however up to 20% of familial isolated pituitary adenomas are caused by germline sequence variants of the aryl-hydrocarbon-receptor interacting protein (AIP) gene. Feline acromegaly has similarities to human acromegalic families with AIP mutations. The aim of this study was to sequence the feline AIP gene, identify sequence variants and compare the AIP gene sequence between feline acromegalic and control cats, and in acromegalic siblings. The feline AIP gene was amplified through PCR using whole blood genomic DNA from 10 acromegalic and 10 control cats, and 3 sibling pairs affected by acromegaly. PCR products were sequenced and compared with the published predicted feline AIP gene. A single nonsynonymous SNP was identified in exon 1 (AIP:c.9T > G) of two acromegalic cats and none of the control cats, as well as both members of one sibling pair. The region of this SNP is considered essential for the interaction of the AIP protein with its receptor. This sequence variant has not previously been reported in humans. Two additional synonymous sequence variants were identified (AIP:c.481C > T and AIP:c.826C > T). This is the first molecular study to investigate a potential genetic cause of feline acromegaly and identified a nonsynonymous AIP single nucleotide polymorphism in 20% of the acromegalic cat population evaluated, as well as in one of the sibling pairs evaluated

Searching for "monogenic diabetes" in dogs using a candidate gene approach

BACKGROUND: Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenced by genetic factors and similarities between canine and human diabetes phenotypes suggest that the same genes might be associated with disease susceptibility in both species. Between 1-5% of human diabetes cases result from mutations in a single gene, including maturity onset diabetes of the adult (MODY) and neonatal diabetes mellitus (NDM). It is not clear whether monogenic forms of diabetes exist within some dog breeds. Identification of forms of canine monogenic diabetes could help to resolve the heterogeneity of the condition and lead to development of breed-specific genetic tests for diabetes susceptibility. RESULTS: Seventeen dog breeds were screened for single nucleotide polymorphisms (SNPs) in eighteen genes that have been associated with human MODY/NDM. Six SNP associations were found from five genes, with one gene (ZFP57) being associated in two different breeds. CONCLUSIONS: Some of the genes that have been associated with susceptibility to MODY and NDM in humans appear to also be associated with canine diabetes, although the limited number of associations identified in this study indicates canine diabetes is a heterogeneous condition and is most likely to be a polygenic trait in most dog breeds. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2052-6687-1-8) contains supplementary material, which is available to authorized users

Point Sources from a Spitzer IRAC Survey of the Galactic Center

We have obtained Spitzer/IRAC observations of the central 2.0 x 1.4 degrees (~280 x 200 pc) of the Galaxy at 3.6-8.0 microns. A point source catalog of 1,065,565 objects is presented. The catalog includes magnitudes for the point sources at 3.6, 4.5, 5.8, and 8.0 microns, as well as JHK photometry from 2MASS. The point source catalog is confusion limited with average limits of 12.4, 12.1, 11.7, and 11.2 magnitudes for [3.6], [4.5], [5.8], and [8.0], respectively. We find that the confusion limits are spatially variable because of stellar surface density, background surface brightness level, and extinction variations across the survey region. The overall distribution of point source density with Galactic latitude and longitude is essentially constant, but structure does appear when sources of different magnitude ranges are selected. Bright stars show a steep decreasing gradient with Galactic latitude, and a slow decreasing gradient with Galactic longitude, with a peak at the position of the Galactic center. From IRAC color-magnitude and color-color diagrams, we conclude that most of the point sources in our catalog have IRAC magnitudes and colors characteristic of red giant and AGB stars.Comment: 44 pages, 13 figures, ApJS in pres

Observations and analysis of two type IIP supernovae: the intrinsically faint object SN 2005cs and the ambiguous object SN 2005ay

Aims: To derive observational properties and physical parameters of the progenitor stars of type IIP supernovae SN 2005ay and SN 2005cs from their U,B,V,R,I CCD photometry, and to define their velocity behaviour. Methods: Light curves are analysed, and the velocities and spectral characteristics of SN 2005cs are obtained using synthetic spectra modeling. Results: Both supernovae are found to be fainter than the average SN IIP, with SN 2005cs being more subluminous and showing slight brightening in the second half of plateau stage in the V,R,I bands and a low expansion velocity. The effects of two different plausible distance moduli on the derived physical parameters of SN 2005ay are considered. Two approaches are used to recover the amounts of the ejected 56Ni, indicating masses of the order of 0.02 Msun, although late luminosities might indicate a higher amount for SN 2005ay, especially for the large distance case. Constraints on the progenitor properties are also presented, based on empirical analytical models. Two approaches are used to estimate the expansion velocities at the middle of the plateau phase. SN 2005cs represents an example of where all 3 physical parameters, velocity, energy and 56Ni mass are lower than average, a correlation not always observed in SNe IIP. SN 2005ay may belong to the same class if the shorter distance possibility is adopted. Furthermore, the estimated mass range for SN 2005cs is in agreement with limits established by using pre-supernova imaging.Comment: 8 pages, 6 figures, to be published in A&A vol.460, issue 3, December 200

Stable Propagation of a Burst Through a One-Dimensional Homogeneous Excitatory Chain Model of Songbird Nucleus HVC

We demonstrate numerically that a brief burst consisting of two to six spikes can propagate in a stable manner through a one-dimensional homogeneous feedforward chain of non-bursting neurons with excitatory synaptic connections. Our results are obtained for two kinds of neuronal models, leaky integrate-and-fire (LIF) neurons and Hodgkin-Huxley (HH) neurons with five conductances. Over a range of parameters such as the maximum synaptic conductance, both kinds of chains are found to have multiple attractors of propagating bursts, with each attractor being distinguished by the number of spikes and total duration of the propagating burst. These results make plausible the hypothesis that sparse precisely-timed sequential bursts observed in projection neurons of nucleus HVC of a singing zebra finch are intrinsic and causally related.Comment: 13 pages, 6 figure

Reprocessing the Hipparcos data for evolved giant stars II. Absolute magnitudes for the R-type carbon stars

The Hipparcos Intermediate Astrometric Data for carbon stars have been reprocessed using an algorithm which provides an objective criterion for rejecting anomalous data points and constrains the parallax to be positive. New parallax solutions have been derived for 317 cool carbon stars, mostly of types R and N. In this paper we discuss the results for the R stars. The most important result is that the early R stars (i.e., R0 - R3) have absolute magnitudes and V-K colors locating them among red clump giants in the Hertzsprung-Russell diagram. Stars with subtypes R4 - R9 tend to be cooler and have similar luminosity to the N-type carbon stars, as confirmed by their position in the (J-H, H-K) color-color diagram. The sample of early R-type stars selected from the Hipparcos Catalogue appears to be approximately complete to magnitude K_0 ~ 7, translating into a completeness distance of 600 pc if all R stars had M_K= -2 (400 pc if M_K= -1). With about 30 early R-type stars in that volume, they comprise about 0.04% (0.14% for M_K= -1) of the red clump stars in the solar neighborhood. Identification with the red clump locates these stars at the helium core burning stage of stellar evolution, while the N stars are on the asymptotic giant branch, where helium shell burning occurs. The present analysis suggests that for a small fraction of the helium core burning stars (far lower than the fraction of helium shell-burning stars), carbon produced in the interior is mixed to the atmosphere in sufficient quantities to form a carbon star.Comment: 11 pages, 6 figures, A&A Latex. To appear in A&

SN 2009E: a faint clone of SN 1987A

In this paper we investigate the properties of SN 2009E, which exploded in a relatively nearby spiral galaxy (NGC 4141) and that is probably the faintest 1987A-like supernova discovered so far. Spectroscopic observations which started about 2 months after the supernova explosion, highlight significant differences between SN 2009E and the prototypical SN 1987A. Modelling the data of SN 2009E allows us to constrain the explosion parameters and the properties of the progenitor star, and compare the inferred estimates with those available for the similar SNe 1987A and 1998A. The light curve of SN 2009E is less luminous than that of SN 1987A and the other members of this class, and the maximum light curve peak is reached at a slightly later epoch than in SN 1987A. Late-time photometric observations suggest that SN 2009E ejected about 0.04 solar masses of 56Ni, which is the smallest 56Ni mass in our sample of 1987A-like events. Modelling the observations with a radiation hydrodynamics code, we infer for SN 2009E a kinetic plus thermal energy of about 0.6 foe, an initial radius of ~7 x 10^12 cm and an ejected mass of ~19 solar masses. The photospheric spectra show a number of narrow (v~1800 km/s) metal lines, with unusually strong Ba II lines. The nebular spectrum displays narrow emission lines of H, Na I, [Ca II] and [O I], with the [O I] feature being relatively strong compared to the [Ca II] doublet. The overall spectroscopic evolution is reminiscent of that of the faint 56Ni-poor type II-plateau supernovae. This suggests that SN 2009E belongs to the low-luminosity, low 56Ni mass, low-energy tail in the distribution of the 1987A-like objects in the same manner as SN 1997D and similar events represent the faint tail in the distribution of physical properties for normal type II-plateau supernovae.Comment: 19 pages, 9 figures (+7 in appendix); accepted for publication in A&A on 3 November 201