Procedural life cycle inventory of chemical products at laboratory and pilot scale: a compendium

Life Cycle Assessment (LCA) is widely acknowledged by academia and industry as a key tool for promoting environmental sustainability within the field of green chemistry. However, certain barriers hinder its straightforward applicability, primarily stemming from data unavailability when the target reaction falls outside the direct or indirect control of LCA practitioners. Several methodologies have been proposed over the years to address the data gap in terms of mass, energy, catalyst, emissions, recovery, etc. These have been compiled into a compendium aimed at providing comprehensive guidance for practitioners in overcoming this challenge. This procedural life cycle inventory aims to facilitate the adoption of LCA by ensuring that key environmental steps, such as energy consumption, are not overlooked, and that mass balances are complete. The methodology is presented through a case study focusing on bio-based maleic anhydride

Sustainable and environmental catalysis

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The “SQUIID claim”: A novel LCA-based indicator for food dishes

Many studies aimed at estimating the environmental impacts associated with the food sector, but most of the existing developed indicators limited the problem only to the climate change, while it is well-known that the food sector may extend its influence on a wider spectrum of environmental categories. In this work, the Life Cycle Assessment was applied to a list of 1001 recipes for an Italian food canteen, prepared with more than 150 ingredients, with the purpose to develop a comprehensive environmental indicator (namely, SQUIID: Simplified Quantitative Impact Indicator for food Dishes). SQUIID includes in the evaluation the environmental categories showing a significant contribution (at least 86%) to the single score, i.e., global warming potential (GWP), particulate matter formation, land occupation, human non-carcinogenic toxicity and water consumption. The list of recipes was then analyzed under three perspectives: mass, GWP and SQUIID. The mass perspective indicates that the list of recipes contains a fairly balanced amount of ingredients, pointing out a remarkable diversification of the menu in the examined canteen. Concerning GWP and SQUIID spheres, meat-based and fish-based recipes resulted the main impacting ones (77% for the former and 73% for the latter), demonstrating to be the two classes mainly responsible for the environmental impacts observed, even if the vegetarian and vegan food dishes represent the 41% in mass. Meat-based dishes represent the 42% of the entire list of recipes in case of GWP, when adopting SQUIID, their overall contribution is reduced to the 35%. In fact, the main percentage of SQUIID is instead attributed to fish, raising from 31% (GWP) to 43%. Such variation demonstrated the relevance of the four additional selected categories for a final and comprehensive evaluation, proving that GWP-based indicators provide to the consumer only a partial representation of the environmental issue

Regional food consumption in Italy, a life cycle analysis

Urbanization and globalization have led to an increasing concern and focus on the sustainability of the food sector, particularly in discussing the composition of consumers' diets. This study examines Italian consumption habits, categorizing them into four macro-geographical areas (North-West, North-East, Center, South, and Islands), utilizing public data obtained from surveys including 3323 individuals, and assesses their environmental impacts through the application of the Life Cycle Assessment methodology. The findings unveil distinct dietary patterns across Italian macro-regions, indicative of cultural disparities, and present avenues for promoting environmentally sustainable dietary choices. The study identifies meat consumption as the primary environmental concern across all macro-regions, with fish emerging as a secondary contributor to particulate matter formation. Pork and poultry exhibit notable impacts within toxicity-related categories. Additionally, the research underscores challenges in data collection, notably the absence of a site-specific Italian database, and underscores the necessity for more recent consumption data to accurately capture contemporary Italian dietary habits. Finally, the study demonstrates that addressing the issue from a macro-regional perspective allows for more targeted and dedicated cultural interventions

High-Resolution Ultrasound Spectroscopy for the Determination of Phospholipid Transitions in Liposomal Dispersions

High-resolution ultrasound spectroscopy (HR-US) is a spectroscopic technique using ultrasound waves at high frequencies to investigate the structural properties of dispersed materials. This technique is able to monitor the variation of ultrasound parameters (sound speed and attenuation) due to the interaction of ultrasound waves with samples as a function of temperature and concentration. Despite being employed for the characterization of several colloidal systems, there is a lack in the literature regarding the comparison between the potential of HR-US for the determination of phospholipid thermal transitions and that of other common techniques both for loaded or unloaded liposomes. Thermal transitions of liposomes composed of pure phospholipids (dimyristoylphosphatidylcholine, DMPC; dipalmitoylphosphatidylcholine, DPPC and distearoylphosphatidylcholine, DSPC), cholesterol and their mixtures were investigated by HR-US in comparison to the most commonly employed microcalorimetry (mDSC) and dynamic light scattering (DLS). Moreover, tramadol hydrochloride, caffeine or miconazole nitrate as model drugs were loaded in DPPC liposomes to study the effect of their incorporation on thermal properties of a phospholipid bilayer. HR-US provided the determination of phospholipid sol-gel transition temperatures from both attenuation and sound speed that are comparable to those calculated by mDSC and DLS techniques for all analysed liposomal dispersions, both loaded and unloaded. Therefore, HR-US is proposed here as an alternative technique to determine the transition temperature of phospholipid membrane in liposomes

Methyl Methacrylate Production Processes: A Comparative Analysis of Alternatives Using the Life Cycle Assessment Methodology

Green chemistry is part of the chemical industry’s response to calls for improved environmental responsibility. It is also one of the industry’s several paths to redemption from its erstwhile infamous reputation as one of the most polluting sectors. We studied the impacts of implementing some of these principles on the production of methyl methacrylate (MMA), the monomer of PMMA popularly known as acrylic glass. This study used life cycle assessment (LCA) methodology to compare the potential environmental impacts of three different approaches to the production of MMA. Two of these are established industrial pathways: the acetocyanohydrin process (ACH-MMA) and the Alpha Lucite process (AL-MMA), which represent the conventional and a fastrising industrial route, respectively, while the third, the in situ formaldehyde process (inFAL-MMA) is a lab-based process. The scenarios were evaluated using cumulative energy demand (CED) and the ReCiPe 2016 impact assessment methods. The results obtained highlighted some hotspots that can benefit from process improvements and careful material and energy source selection. It also underscored that AL-MMA can record significant improvements in environmental performance by reducing the overall resource intensity of the process. inFAL-MMA synthesis was adjudged to be the most evolved of the three alternatives with respect to green chemistry principles; hence, the study sought to investigate possible environmental gains attributable to this. Some limitations of the methodology uncovered during the study necessitated the use of an additional tool for further assessment of the potential risk. Thus, the GREEN MOTION was adopted to examine this relationship. Overall, the study established hotspots and areas for process improvements in the scenarios examined. It also confirmed the importance of different factors like data quality, degree of process optimization, energy source, and others on the results that can be obtained in a LCA

An overview of natural polymers as reinforcing agents for 3D printing

Three-dimensional (3D) printing, or additive manufacturing, is a group of innovative technologies that are increasingly employed for the production of 3D objects in different fields, including pharmaceutics, engineering, agri-food and medicines. The most processed materials by 3D printing techniques (e.g., fused deposition modelling, FDM; selective laser sintering, SLS; stereolithography, SLA) are polymeric materials since they offer chemical resistance, are low cost and have easy processability. However, one main drawback of using these materials alone (e.g., polylactic acid, PLA) in the manufacturing process is related to the poor mechanical and tensile properties of the final product. To overcome these limitations, fillers can be added to the polymeric matrix during the manufacturing to act as reinforcing agents. These include inorganic or organic materials such as glass, carbon fibers, silicon, ceramic or metals. One emerging approach is the employment of natural polymers (polysaccharides and proteins) as reinforcing agents, which are extracted from plants or obtained from biomasses or agricultural/industrial wastes. The advantages of using these natural materials as fillers for 3D printing are related to their availability together with the possibility of producing printed specimens with a smaller environmental impact and higher biodegradability. Therefore, they represent a “green option” for 3D printing processing, and many studies have been published in the last year to evaluate their ability to improve the mechanical properties of 3D printed objects. The present review provides an overview of the recent literature regarding natural polymers as reinforcing agents for 3D printing

Levulinic acid biorefinery in a life cycle perspective

Nowadays there is a strong urge to replace the fossil-based chemicals and fuels with biobased ones. In this context, the 7th principle of the green chemistry, the Sustainable Development Goals (SDGs) and the recent Safe and Sustainable by Design (SSbD) approach are the main references. Among the various biorefineries, lignocellulosic biomasses represent the most abundant resource to explore. Considering the vast plethora of useful molecules produced from lignocellulosic biomasses, levulinic acid embodies a potential starting material for the preparation of high value-added chemicals. This review explores the preparation of levulinic acid form lignocellulosic biomasses and its further valorization to high-value added compounds (gamma-valerolactone, ketals and methyl/ethyl levulinate), considering the current state of the art of the available synthetic strategies, in a life cycle perspective considering the adoption of the life cycle assessment (LCA) methodology

Effect of Cocoa Roasting on Chocolate Polyphenols Evolution

Cocoa and chocolate antioxidants might contribute to human health through, for instance, blood flow improvement or blood pressure and glycemia reduction, as well as cognitive function improvement. Unfortunately, polyphenol content is reduced during cocoa fermentation, drying, roasting and all the other phases involved in the chocolate production. Here, we investigated the evolution of the polyphenol content during all the different steps of chocolate production, with a special emphasis on roasting (3 different roasting cycles with 80, 100, and 130 °C as maximum temperature). Samples were followed throughout all processes by evaluating the total polyphenols content, the antioxidant power, the epicatechin content, and epicatechin mean degree of polymerization (phloroglucinol adducts method). Results showed a similar trend for total polyphenol content and antioxidant power with an unexpected bell-shaped curve: an increase followed by a decrease for the three different roasting temperatures. At the intermediate temperature (100 °C), the higher polyphenol content was found just after roasting. The epicatechin content had a trend similar to that of total polyphenol content but, interestingly, the mean degree of polymerization data had the opposite behavior with some deviation in the case of the highest temperature, probably due to epicatechin degradation. It seems likely that roasting can free epicatechin from oligomers, as a consequence of oligomers remodeling

Hyperlipidemia control using the innovative association of lupin proteins and chitosan and α-cyclodextrin dietary fibers: food supplement formulation, molecular docking study, and in vivo evaluation

A dietary supplement potentially employed for the treatment and/or prevention of hyperlipidemia was developed. The proposed product is composed of a combination of natural macromolecules as chitosan (CH), α-cyclodextrin (α-CD), and lupin proteins (LP). First, the anti-hyperlipidemic effect of the α-CD and LP binary mixture was assessed and compared to that of the extensively utilized anti-hyperlipidemic CH, using a hyperlipidemic rat model. The anti-hyperlipidemic effect of their combination was also demonstrated. Additionally, ligand–target and protein–protein docking studies were performed. The in vivo results displayed that on intergroup comparison, blending CH, α-CD, and LP promised a superior therapeutic effect over α-CD and LP mixture, CH, and the marketed atorvastatin, potentiating a considerable reduction of serum lipid profile and the calculated atherogenic risk predictor indices. Molecular docking study revealed a weak hydrophobic cholesterol–CH and cholesterol–α-CD interactions, while protein–protein docking study showed a good lipase–LP interaction, involving eight hydrogen bonds. Then, on the base of the in vivo and docking study results, a tablet formulation was produced aimed to overcome the negative technological effects of the anti-hyperlipidemic macromolecules: long disintegration time and tablets mechanical resistance. The optimized tablet formulation has a disintegration time shorter than 15 min and a weight loss from friability test lower than 1%, which are in line with the regulatory specifications for uncoated tablets. Overall, this anti-hyperlipidemic formulation is attractive for the dietary and nutraceutical market, despite further clinical studies are required to assess the efficacy, possible side effects, and product compliance