30 research outputs found
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
Get PDFThe Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase signaling. Crk proteins integrate signals from a wide variety of sources, including growth factors, extracellular matrix molecules, bacterial pathogens, and apoptotic cells. Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases, including cancer and susceptibility to pathogen infections. Recent structural work has identified new and unusual insights into the regulation of Crk proteins, providing a rationale for how Crk can sense diverse signals and produce a myriad of biological responses
Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5′-phosphatase interaction with c-Abl
Full text linkWomen's concerns regarding sexually transmitted infection compared with unwanted pregnancy
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Proteoglycans Mediate Cationic Liposome-DNA Complex-based Gene Delivery in Vitro and in Vivo
No full textPatient satisfaction is best predicted by low decisional regret among women with cancer seeking fertility preservation counseling (FPC)
Full text linkBiofuels from microalgae: Lipid extraction and methane production from the residual biomass in a biorefinery approach
No full textCONSTRUCT VALIDITY OF A NEW MIGRAINE SATISFACTION WITH TREATMENT QUESTIONNAIRE
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