The tactical mimicry of social enterprise strategies: acting ‘as if’ in the everyday life of third sector organizations

Using England as a paradigmatic case of the „enterprising up ‟ of the third sector through social enterprise policies and programs, this article sheds light on resistance as enacted through dramaturgical identification with government strategies. Drawing from a longitudinal qualitative research study, which is interpreted via Michel de Certeau‟s theory of the everyday, we present the case study of Teak, a charitable regeneration company, to illustrate how its Chief Executive Liam „acted as ‟ a social entrepreneur in order to gain access to important resources. We establish „tactical mimicry ‟ as a sensitizing concept to suggest that third sector practitioners ‟ identification with the normative premises of „social enterprise ‟ is part of a parasitical prosaics geared toward appropriating public money. While tactical mimicry conforms to strategies only in order to exploit them, its ultimate aim is to increase potentials of collective agency outside the direct influence of power. The contribution we make is threefold: first, we extend the recent debate on productive resistance by highlighting how „playing the game ‟ without changing existing relations of power can nevertheless produce largely favorable outcomes. Second, we suggest that recognition of the productive potential of tactical mimicry requires methodologies which pay attention to the spatial and temporal dynamics of resistance. And third, we argue that explaining „social enterprise‟ without consideration of the non-discursive, mainly financial resources made available to those who identify with it, necessarily risks overlooking a crucial element of the dramaturgical dynamic of discourse

The quiet editor: Ivan Vladislavić and South African cultural production

This article examines the literary and sociological significance of Ivan Vladislavić’s "double life” (Lahire, 2010: n.p.) as both editor and writer. With reference to a number of his editorial roles as well as the joint projects he has worked on with writers and visual artists, the article considers how Vladislavić’s work with others spreads symbolic value. Described by one of his clients as the “quiet editor”, Vladislavić can be read as a new kind of author; what he terms “creative editing” (Steyn, 2012: n.p.) as a new kind of writing, through which more traditional models of authorship and literary production are thrown into question — less Bourdieu’s (1984) “field of literary production” or Casanova’s (2004: 82) “world literary space”, red in tooth and claw, amd more Howard Becker’s “art world”: a convivial “network of cooperating people, all of whose work is essential to the final outcome” (1982: 25)

A geometric dual of c-extremization

We consider supersymmetric AdS3 × Y7 and AdS2 × Y9 solutions of type IIB and D = 11 supergravity, respectively, that are holographically dual to SCFTs with (0, 2) supersymmetry in two dimensions and N = 2 supersymmetry in one dimension. The geometry of Y2n+1, which can be defined for n ≥ 3, shares many similarities with SasakiEinstein geometry, including the existence of a canonical R-symmetry Killing vector, but there are also some crucial differences. We show that the R-symmetry Killing vector may be determined by extremizing a function that depends only on certain global, topological data. In particular, assuming it exists, for n = 3 one can compute the central charge of an AdS3 × Y7 solution without knowing its explicit form. We interpret this as a geometric dual of c-extremization in (0, 2) SCFTs. For the case of AdS2 × Y9 solutions we show that the extremal problem can be used to obtain properties of the dual quantum mechanics, including obtaining the entropy of a class of supersymmetric black holes in AdS4. We also study many specific examples of the type AdS3×T 2×Y5, including a new family of explicit supergravity solutions. In addition we discuss the possibility that the (0, 2) SCFTs dual to these solutions can arise from the compactification on T 2 of certain d = 4 quiver gauge theories associated with five-dimensional Sasaki-Einstein metrics and, surprisingly, come to a negative conclusion

Computer-assisted pre-operative automatic segmentation and registration tool for malunited radius osteotomy: A proof-of-concept study

Corrective osteotomy is a standard treatment for distal radius fractures in malunited radius cases. In order to increase the efficiency of the osteotomy pre-operative plan, in this study, a proof-of-concept framework of automatic computer-assisted segmentation and registration tool was developed for the purpose of malunited radius osteotomy pre-operative planning. The program consisted of the functions of segmentation, virtual cutting, automatic alignment and registration. One computed tomography (CT) scanning dataset of a patient's bilateral forearm was employed as an illustration example in this study. Three templates of 3D models including the healthy radius, and the pre- and post-correction injured radius were output as STL geometries for pre-operative plan purposes

Mapping differential interactomes by affinity purification coupled with data independent mass spectrometry acquisition

Characterizing changes in protein-protein interactions associated with sequence variants (e.g. disease-associated mutations or splice forms) or following exposure to drugs, growth factors or hormones is critical to understanding how protein complexes are built, localized and regulated. Affinity purification (AP) coupled with mass spectrometry permits the analysis of protein interactions under near-physiological conditions, yet monitoring interaction changes requires the development of a robust and sensitive quantitative approach, especially for large-scale studies where cost and time are major considerations. To this end, we have coupled AP to data-independent mass spectrometric acquisition (SWATH), and implemented an automated data extraction and statistical analysis pipeline to score modulated interactions. Here, we use AP-SWATH to characterize changes in protein-protein interactions imparted by the HSP90 inhibitor NVP-AUY922 or melanoma-associated mutations in the human kinase CDK4. We show that AP-SWATH is a robust label-free approach to characterize such changes, and propose a scalable pipeline for systems biology studies

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations

Protein-protein interactions govern almost all cellular functions. These complex networks of stable and transient associations can be mapped by affinity purification mass spectrometry (AP-MS) and complementary proximity-based labeling methods such as BioID. To exploit the advantages of both strategies, we here design and optimize an integrated approach combining AP-MS and BioID in a single construct, which we term MAC-tag. We systematically apply the MAC-tag approach to 18 subcellular and 3 sub-organelle localization markers, generating a molecular context database, which can be used to define a protein's molecular location. In addition, we show that combining the AP-MS and BioID results makes it possible to obtain interaction distances within a protein complex. Taken together, our integrated strategy enables the comprehensive mapping of the physical and functional interactions of proteins, defining their molecular context and improving our understanding of the cellular interactome.Peer reviewe