Use of the metastatic breast cancer progression (MBC-P) questionnaire to assess the value of progression-free survival for women with metastatic breast cancer.

While overall survival (OS) has historically been the primary endpoint for clinical trials in oncology, progression-free survival (PFS) has gained acceptance as a valuable surrogate endpoint. However, there are no known published reports about the value of PFS from the patient's perspective. We developed a questionnaire that included items regarding quality of life (QoL) and the importance of different treatment outcomes and presented hypothetical scenarios for which respondents were asked to indicate their preferences concerning treatments as they relate to PFS. 282 women with metastatic breast cancer (MBC), ranging in age from 21 to 80 years completed an online version of this questionnaire. The majority of women (66 %) had been diagnosed with MBC within the previous 3 years and 56 % had been told their MBC had progressed. When asked to rank five treatment characteristics from most important to least important, respondents ranked "extending PFS" as the second most important treatment outcome after OS. When presented with a hypothetical scenario of two women receiving different treatments, respondents preferred the treatment that resulted in longer PFS (16 vs. 12 months), even when OS and side effects were assumed to be equal. Specifically, when asked to consider which woman within the hypothetical scenario had better QoL, physical functioning, and emotional well-being, respondents more often chose the woman who experienced longer PFS (QoL: 40 vs. 6 %; physical functioning: 32 vs. 8 %; emotional well-being: 58 vs. 6 %) compared to the woman within the hypothetical scenario who had a shorter time of progression. Respondents rated their own QoL highest after being told their MBC was responding to treatment (mean score 76.6) versus after the initial diagnosis of breast cancer and MBC (68.5 and 60.3). These findings suggest that extending PFS is an important treatment outcome and, from a patient perspective, improves overall QoL, physical functioning, and emotional well-being

Studies in a transonic rotor aerodynamics and noise facility

The design, construction and testing of a transonic rotor aerodynamics and noise facility was undertaken, using a rotating arm blade element support technique. This approach provides a research capability intermediate between that of a stationary element in a moving flow and that of a complete rotating blade system, and permits the acoustic properties of blade tip elements to be studied in isolation. This approach is an inexpensive means of obtaining data at high subsonic and transonic tip speeds on the effect of variations in tip geometry. The facility may be suitable for research on broad band noise and discrete noise in addition to high-speed noise. Initial tests were conducted over the Mach number range 0.3 to 0.93 and confirmed the adequacy of the acoustic treatment used in the facility to avoid reflection from the enclosure

A theory-based approach to understanding condom errors and problems reported by men attending an STI clinic

The official published version can be accessed from the link below - Copyright @ 2008 Springer VerlagWe employed the information–motivation–behavioral skills (IMB) model to guide an investigation of correlates for correct condom use among 278 adult (18–35 years old) male clients attending a sexually transmitted infection (STI) clinic. An anonymous questionnaire aided by a CD-recording of the questions was administered. Linear Structural Relations Program was used to conduct path analyses of the hypothesized IMB model. Parameter estimates showed that while information did not directly affect behavioral skills, it did have a direct (negative) effect on condom use errors. Motivation had a significant direct (positive) effect on behavioral skills and a significant indirect (positive) effect on condom use errors through behavioral skills. Behavioral skills had a direct (negative) effect on condom use errors. Among men attending a public STI clinic, these findings suggest brief, clinic-based, safer sex programs for men who have sex with women should incorporate activities to convey correct condom use information, instill motivation to use condoms correctly, and directly enhance men’s behavioral skills for correct use of condoms

What’s a threat on social media? How Black and Latino Chicago young men define and navigate threats online

Youth living in violent urban neighborhoods increasingly post messages online from urban street corners. The decline of the digital divide and the proliferation of social media platforms connect youth to peer communities who may share experiences with neighborhood stress and trauma. Social media can also be used for targeted retribution when threats and insults are directed at individuals or groups. Recent research suggests that gang-involved youth may use social media to brag, post fight videos, insult, and threaten—a phenomenon termed Internet banging. In this article, we leverage “code of the digital street” to understand how and in what ways social media facilitates urban-based youth violence. We utilize qualitative interviews from 33 Black and Latino young men who frequent violence prevention programs and live in violent neighborhoods in Chicago. Emerging themes describe how and why online threats are conceptualized on social media. Implications for violence prevention and criminal investigations are discussed

Template-dependent multiple displacement amplification for profiling human circulating RNA

Multiple displacement amplification (MDA) is widely used in whole-genome/transcriptome amplification. However, template-independent amplification (TIA) in MDA is a commonly observed phenomenon, particularly when using high concentrations of random hexamer primers and extended incubation times. Here, we demonstrate that the use of random pentamer primers with 5´ ends blocked by a C18 spacer results in MDA solely in a template-dependent manner, a technique we have named tdMDA. Together with an optimized procedure for the removal of residual genomic DNA during RNA extraction, tdMDA was used to profile circulating RNA from 0.2 mL of patient sera. In comparison to regular MDA, tdMDA demonstrated a lack of quantifiable DNA amplification in the negative control, a remarkable reduction of unmapped reads from Illumina sequencing (7 ± 10.9% versus 58.6 ± 39%, P = 0.006), and increased mapping rates of the serum transcriptome (26.9 ± 7.9% versus 5.8 ± 8.2%, P = 3.8 × 10-4). Transcriptome profiles could be used to separate patients with chronic hepatitis C virus (HCV) infection from those with HCV-associated hepatocellular carcinoma (HCC). We conclude that tdMDA should facilitate RNA-based liquid biopsy, as well as other genome studies with biological specimens having ultralow amounts of genetic material. </jats:p

Health Risk of Obesity in Native American Adolescents

Recent reports demonstrate the need to improve methods for identifying obesity among adolescent minority populations, especially among Native American adolescents. Our study examined several anthropometric measures to see which one was the best indicator of obesity for Native American adolescents. We compared our data with that provided by the Centers for Disease Control and Prevention (CDC), and the National Health and Nutrition Examination Surveys (NHANESIII). We examined which measures diï¬ered signiï¬cantly from the NHANESIII, and which were most eï¬ective for measuring obesity in Native American adolescents. Our study population represented a cross-sectional, epidemiological population (N=183) of Native American students (ages 14-18) from diverse tribal backgrounds at an urban residential high school. We obtained baseline anthropometric measurements of height, weight, waist, triceps skin-fold, and calf skin-fold measures from the Native American students and compared this information with reference data to assess weight classiï¬cation by body mass indices for our population. Under the conditions of our study, we found the calf skin-fold measure to be the best indicator of normal weight in male Native American adolescents, and the triceps skin-fold measure to be the best indicator of obesity in male Native American adolescents. The assessment of health risk by anthropometric measures we obtained appears appropriate for predicting obesity and developing eï¬ective interventions for Native American adolescents in general. Correlations between anthropometric measures and obesity in our study population may prove of signiï¬cant interest for monitoring obesity prevention initiatives for Native American adolescents