Kerjasama Antar Notaris dalam Bentuk Persekutuan Perdata

Berlakunya Undang-Undang Nomor 30 Tahun 2004 tentang Jabatan Notaris (untuk selanjutnya disebut UUJN) melahirkan perkembangan hukum di bidang kenotariatan yaitu perserikatan perdata sebagai bentuk kerjasama antar Notaris sebagaimana di atur dalam Pasal 20. Menindaklanjuti Pasal 20 ayat (3) UUJN, diterbitkanlah Peraturan Menteri Hukum dan Hak Asasi Manusia Republik Indonesia Nomor M.HH.01.02.12 Tahun 2010 tentang Persyaratan Menjalankan Jabatan Notaris Dalam Bentuk Perserikatan Perdata. Permasalahan muncul ketika diundangkannya Undang-Undang Nomor 2 Tahun 2014 tentang Perubahan Atas Undang-Undang Nomor 30 Tahun 2004 tentang Jabatan Notaris (untuk selanjutnya disebut UUJN-P) yang menghapus ketentuan Pasal 20 ayat (3) UUJN dengan menimbulkan akibat hukum bahwa ketentuan lebih lanjut sebagaimana Peraturan Menteri Hukum dan Hak Asasi Manusia Republik Indonesia Nomor M.HH.01.02.12 Tahun 2010 tidak lagi berlaku. Peraturan pelaksana ini sesungguhnya sangat diperlukan, mengingat dalam Pasal 20 maupun dalam Penjelasan Pasal 20 UUJN-P ini tidak memberikan definisi yang konkrit mengenai persekutuan perdata. Hasil dari penelitian ini dapat disimpulkan karakteristik persekutuan perdata Notaris yang diatur dalam UUJN-P adalah persekutuan yang bertujuan tidak menjalankan Perusahaan dalam artian komersil dan keuntungan bukan menjadi orientasi bagi para Notaris yang bergabung dalam persekutuan perdata Notaris. Persekutuan perdata Notaris ini merupakan kantor bersama. Klien yang datang pada persekutuan perdata Notaris, nantinya akan menghadap pada salah satu Notaris yang tergabung di dalam persekutuan perdata Notaris tersebut, sehingga yang bertanggung jawab terhadap klien tersebut adalah Notaris yang bersangkutan

Refinement of the taxonomic structure of 16SrXI and 16SrXIV phytoplasmas of gramineous plants using multilocus sequence typing

Phytoplasmas that infect gramineous plants, including Napier grass stunt, sugarcane whiteleaf, sugarcane grassy shoot, and Bermuda grass whiteleaf, have been classified into two closely related groups, 16SrXI and 16SrXIV, based on the 16S ribosomal RNA (rRNA) gene. Subsequently, phytoplasmas associated with coconut and Areca palm in southern India and Sri Lanka have been added into the 16SrXI group. However, the 16S rRNA gene gives relatively poor resolution between these phytoplasmas. In this study, a new set of universal phytoplasma primers that amplify approximately 1 kb of the leucyl transfer RNA synthetase (leuS) gene have been validated on a broad range of phytoplasma taxonomic groups. These have been used along with partial sequences of the secA gene to clarify the taxonomic classification of 16SrXI and 16SrXIV phytoplasmas. Based on this data, the sugarcane whiteleaf and grassy shoot phytoplasmas appear to be the same phytoplasma. The Napier grass stunt phytoplasma forms a distinct group from the Bermuda grass whiteleaf and sugarcane phytoplasmas, suggesting that Napier grass stunt should be in its own ‘Candidatus Phytoplasma sp.’. The phytoplasmas associated with coconut and arecanut in southern India and Sri Lanka, which are in the same 16SrXI group, appear in different groups based on secA analysis

Oxidative Stress Induced Liver Damage in Dengue Is Exacerbated in Those With Obesity

Background: As there are limited data on the association of obesity with liver dysfunction and oxidative stress in patients with acute Dengue, we investigated liver dysfunction associated with obesity, oxidative stress, and inflammatory markers in a large cohort of patients with varying severity of illness. Methods: Five hundred seventy-seven adults with a duration of illness ≤4 days at time of admission were followed up from admission to discharge. Aspartate transaminase (AST), alanine transaminase (ALT), C-reactive protein, ferritin, 4-hydroxynonenal (4-HNE), and malondialdehyde (MDA) levels were measured, along with the height, weight, and waist circumference. Results: AST, ALT, CRP, and ferritin levels were significantly higher in patients with central obesity (waist circumference of ≥80 cm in women or ≥90 cm in men) compared with leaner individuals. ALT and CRP levels were also significantly higher in patients with a body mass index (BMI) of ≥23.9 kg/m2. 4-HNE levels significantly increased with the rise in AST levels and with ALT levels, although the increase was not significant. In contrast, MDA levels gradually decreased with the rise in AST levels and ALT levels. There were no differences in 4-HNE and MDA levels in relation to clinical disease severity. However, MDA levels were significantly higher in younger individuals and leaner individuals with a normal BMI. Furthermore, MDA levels inversely correlated with serum ferritin levels, while AST, ALT, and CRP levels significantly correlated with ferritin levels. Conclusions: 4-HNE and MDA appear to play different roles in the pathogenesis of Dengue, which should be further investigated for identification of therapeutic targets for treatment of Dengue

Nanoplatforms:The future of oral cancer treatment

Background and AimsCytotoxicity is a key disadvantage of using chemotherapeutic drugs to treat cancer. This can be overcome by encapsulating chemotherapeutic drugs in suitable carriers for targeted delivery, allowing them to be released only at the cancerous sites. Herein, we aim to review the recent scientific developments in the utilization of nanotechnology-based drug delivery systems for treating oral malignancies that can lead to further improvements in clinical practice.MethodsA comprehensive literature search was conducted on PubMed, Google Scholar, ScienceDirect, and other notable databases to identify recent peer-reviewed clinical trials, reviews, and research articles related to nanoplatforms and their applications in oral cancer treatment.ResultsNanoplatforms offer a revolutionary strategy to overcome the challenges associated with conventional oral cancer treatments, such as poor drug solubility, non-specific targeting, and systemic toxicity. These nanoscale drug delivery systems encompass various formulations, including liposomes, polymeric nanoparticles, dendrimers, and hydrogels, which facilitate controlled release and targeted delivery of therapeutic agents to oral cancer sites. By exploiting the enhanced permeability and retention effect, Nanoplatforms accumulate preferentially in the tumor microenvironment, increasing drug concentration and minimizing damage to healthy tissues. Additionally, nanoplatforms can be engineered to carry multiple drugs or a combination of drugs and diagnostic agents, enabling personalized and precise treatment approaches.ConclusionThe utilization of nanoplatforms in oral cancer treatment holds significant promise in revolutionizing therapeutic strategies. Despite the promising results in preclinical studies, further research is required to evaluate the safety, efficacy, and long-term effects of nanoformulations in clinical settings. If successfully translated into clinical practice, nanoplatform-based therapies have the potential to improve patient outcomes, reduce side effects, and pave the way for more personalized and effective oral cancer treatments

Competences of physiotherapists and nurses working with older adults in Sri Lanka: a need analysis exploratory study with students, academics and health professionals

Background & Aim: The population of Sri Lanka (SL) is rapidly aging, with a growing demand for healthcare professionals skilled in geriatric care. Nurses and physiotherapists play a crucial role in the management of the health and well-being of older adults. This survey aimed to identify the current resources and demands in the professional competences for physiotherapy and nursing professionals working with older adults in SL. Methods: An observational cross-sectional study was conducted among physiotherapists and nurses working in health care settings in SL, academic staff members involved in teaching, training and research, and final year physiotherapy and nursing undergraduates in selected state universities in SL. All the participants completed an online survey consisting of general socio-demographic information, professional and education-related information, knowledge, skills, and clinical and non-clinical competences required for older adult care. Results: Among the 189 respondents (mean age=32.44; SD=8.16 years), 145 (76.7%) were females, 113 (59.8%) were physiotherapists, and 76 (40.2%) were nurses. Of the total participants, 54 (28.6%) were academic staff members, 64 (33.9%) were final-year undergraduates and 71 (37.6%) were healthcare professionals (physiotherapists and nurses). Physiotherapists reported being less confident in “managing chronic pain in older adults” compared to nurses (p=0.03). “Active listening” (88%) and “respect for dignity and autonomy” (76.8%) were identified as more relevant aspects for health professionals under empathy in the care of older adults. “Communication barriers” (83.1%), “financial constraints” (66.7%) and “cultural sensitivity” (63.0%) were identified as challenges that healthcare professionals faced when working with older adults. Conclusions & Recommendations: The findings emphasize the importance of incorporating geriatric-specific training into the undergraduate education and professional development of healthcare providers, particularly nurses and physiotherapists. Policymakers, education and healthcare institutions should collaborate to develop structured training programs that address the identified competency gaps and promote the delivery of holistic and person-centred care for older adults.ei tietoa saavutettavuudest

Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility via a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm’s potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause

Male Oxidative Stress Infertility (MOSI):proposed terminology and clinical practice guidelines for management of idiopathic male infertility

Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility via a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm's potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause