Investigating the impact of feedback update interval on the efficacy of restorative brain–computer interfaces

Restorative brain-computer interfaces (BCIs) have been proposed to enhance stroke rehabilitation. Restorative BCIs are able to close the sensorimotor loop by rewarding motor imagery (MI) with sensory feedback. Despite the promising results from early studies, reaching clinically significant outcomes in a timely fashion is yet to be achieved. This lack of efficacy may be due to suboptimal feedback provision. To the best of our knowledge, the optimal feedback update interval (FUI) during MI remains unexplored. There is evidence that sensory feedback disinhibits the motor cortex. Thus, in this study, we explore how shorter than usual FUIs affect behavioural and neurophysiological measures following BCI training for stroke patients using a single-case proof-of-principle study design. The action research arm test was used as the primary behavioural measure and showed a clinically significant increase (36%) over the course of training. The neurophysiological measures including motor evoked potentials and maximum voluntary contraction showed distinctive changes in early and late phases of BCI training. Thus, this preliminary study may pave the way for running larger studies to further investigate the effect of FUI magnitude on the efficacy of restorative BCIs. It may also elucidate the role of early and late phases of motor learning along the course of BCI training

Evaluation inhibitory effect of essential oil Savory (Satureja hortensis) in food fish

Aflatoxins are a group of fungal metabolites that are produced by the growth of fungi on food. These toxins cause illness in animals and humans, and are important in economic and humans health. In this investigation, inhibitory effects of savory (Satureja hortensis L.) essential oil were evaluated on the growth of Aspergillus flavus in fish food. A gas chromatograph apparatus linked to a mass spectrometer (GC/MS) was used to identify the effective components in Satureja hortensis essential oil after extraction. Essential oils against Aspergillus flavus incubated in PDA media and antifungal properties of essential oil Satureja hortensis was investigated. About of 300g of food samples was weighted and samples were sterilized by autoclave. Fungal suspension (3cc) was spraied into the feed samples, and various concentrations of essential oils (0, 300, 400, 500, 600ppm) added to samples. The samples were incubated at temperature of (±SD) 28±2°C. After 20-40 and 60 days period, randomly, some sampled were taken from containers and the production of aflatoxin B1, B2, G1, and G2 was measured in the laboratory. This result confirms that 500ppm concentrations of oil savory have antifungal properties against Aspergillus flavus

Proprioceptive feedback facilitates motor imagery-related operant learning of sensorimotor β-band modulation

Motor imagery (MI) activates the sensorimotor system independent of actual movements and might be facilitated by neurofeedback. Knowledge on the interaction between feedback modality and the involved frequency bands during MI-related brain self-regulation is still scarce. Previous studies compared the cortical activity during the MI task with concurrent feedback (MI with feedback condition) to cortical activity during the relaxation task where no feedback was provided (relaxation without feedback condition). The observed differences might, therefore, be related to either the task or the feedback. A proper comparison would necessitate studying a relaxation condition with feedback and a MI task condition without feedback as well. Right-handed healthy subjects performed two tasks, i.e., MI and relaxation, in alternating order. Each of the tasks (MI vs. relaxation) was studied with and without feedback. The respective event-driven oscillatory activity, i.e., sensorimotor desynchronization (during MI) or synchronization (during relaxation), was rewarded with contingent feedback. Importantly, feedback onset was delayed to study the task-related cortical activity in the absence of feedback provision during the delay period. The reward modality was alternated every 15 trials between proprioceptive and visual feedback. Proprioceptive input was superior to visual input to increase the range of task-related spectral perturbations in the α- and β-band, and was necessary to consistently achieve MI-related sensorimotor desynchronization (ERD) significantly below baseline. These effects occurred in task periods without feedback as well. The increased accuracy and duration of learned brain self-regulation achieved in the proprioceptive condition was specific to the β-band. MI-related operant learning of brain self-regulation is facilitated by proprioceptive feedback and mediated in the sensorimotor β-band

Effect of Satureja hortensis extracted oil on Aspergillus flavusin fish feed

In a preliminary study, the antifungal properties of essential oil of Satureja hortensis at different tenderness were tested on potato – dextrose agar (PDA). The fungus Aspergillus flavus PTCC 5006 was isolated from pistachio nut obtained from Rafsanjan area, Iran. Among the essential oil compounds, 500 ppm concentration was completely inhibited Aspergillus flavus growth. After determination of the most effective concentration, it was added to fish feeds compound which inhibited fungal growth and production of aflatoxin. Its concentration was determined as 500 ppm and over of essential oil of Satureja hortensis. The essential oil of Satureja hortensis was analyzed by means of GC-MS and their effective factors were evaluated for fish feeds and their results are shown in tables

QUEST-DMC:Background Modelling and Resulting Heat Deposit for a Superfluid Helium-3 Bolometer

We report the results of radioactivity assays and heat leak calculations for a range of common cryogenic materials, considered for use in the QUEST-DMC superfluid 3He dark matter detector. The bolometer, instrumented with nanomechanical resonators, will be sensitive to energy deposits from dark matter interactions. Events from radioactive decays and cosmic rays constitute a significant background and must be precisely modelled, using a combination of material screening and Monte Carlo simulations. However, the results presented here are of wider interest for experiments and quantum devices sensitive to minute heat leaks and spurious events, thus we present heat leak per unit mass or surface area for every material studied. This can inform material choices for other experiments, especially if underground operation is considered – where the radiogenic backgrounds will dominate even at shallow depths

QUEST-DMC: Background Modelling and Resulting Heat Deposit for a Superfluid Helium-3 Bolometer

We report the results of radioactivity assays and heat leak calculations for a range of common cryogenic materials, considered for use in the QUEST-DMC superfluid 3He dark matter detector. The bolometer, instrumented with nanomechanical resonators, will be sensitive to energy deposits from dark matter interactions. Events from radioactive decays and cosmic rays constitute a significant background and must be precisely modelled, using a combination of material screening and Monte Carlo simulations. However, the results presented here are of wider interest for experiments and quantum devices sensitive to minute heat leaks and spurious events, thus we present heat leak per unit mass or surface area for every material studied. This can inform material choices for other experiments, especially if underground operation is considered – where the radiogenic backgrounds will dominate even at shallow depths

QUEST-DMC superfluid ³He detector for sub-GeV dark matter

The focus of dark matter searches to date has been on Weakly Interacting Massive Particles (WIMPs) in the GeV/c2-TeV/c2 mass range. The direct, indirect and collider searches in this mass range have been extensive but ultimately unsuccessful, providing a strong motivation for widening the search outside this range. Here we describe a new concept for a dark matter experiment, employing superfluid 3He as a detector for dark matter that is close to the mass of the proton, of order 1 GeV/c2. The QUEST-DMC detector concept is based on quasiparticle detection in a bolometer cell by a nanomechanical resonator. In this paper we develop the energy measurement methodology and detector response model, simulate candidate dark matter signals and expected background interactions, and calculate the sensitivity of such a detector. We project that such a detector can reach sub-eV nuclear recoil energy threshold, opening up new windows on the parameter space of both spin-dependent and spin-independent interactions of light dark matter candidates

QUEST-DMC superfluid 3 He detector for sub-GeV dark matter

The focus of dark matter searches to date has been on Weakly Interacting Massive Particles (WIMPs) in the GeV/c2-TeV/c2 mass range. The direct, indirect and collider searches in this mass range have been extensive but ultimately unsuccessful, providing a strong motivation for widening the search outside this range. Here we describe a new concept for a dark matter experiment, employing superfluid 3He as a detector for dark matter that is close to the mass of the proton, of order 1 GeV/c2. The QUEST-DMC detector concept is based on quasiparticle detection in a bolometer cell by a nanomechanical resonator. In this paper we develop the energy measurement methodology and detector response model, simulate candidate dark matter signals and expected background interactions, and calculate the sensitivity of such a detector. We project that such a detector can reach sub-eV nuclear recoil energy threshold, opening up new windows on the parameter space of both spin-dependent and spin-independent interactions of light dark matter candidates