Vascular Endothelial Growth Factor Levels in Relation to Oxidative Damage and Antioxidant Status in Patients with Breast Cancer

Purpose: Oxidative stress and angiogenesis are important elements in the pathogenesis of inflammatory diseases and cancer. Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic cytokines and is up-regulated by conditions associated with the generation of free radicals and reactive oxygen intermediates. In this study, we investigated the association between oxidative stress and serum VEGF status in patients with breast cancer. Methods: Forty patients with breast carcinoma, of which 21 were stage II and 19 were stage III, along with 40 ageand gender-matched healthy controls were enrolled. Oxidative stress, total antioxidant status, and VEGF levels in serum were evaluated by spectrophotometric procedures. Malondialdehyde (MDA) levels were measured and antioxidant status was assessed by measuring total antioxidant status (TAS) to assess oxidative damage. Results: VEGF and MDA levels were significantly higher i

Apelinergic System in the Left Ventricle Adverse Remodeling After Myocardial Infarction: A Preliminary Study

Rafał Wyderka,1,2 Bogusława Ołpińska,1 Dorota Diakowska,3 Anna Leśków,3 Łukasz Osuch,1 Michał Borger,1 Barbara Brzezińska,1 Maria Łoboz-Rudnicka,1 Joanna Jaroch1,2 1Department of Cardiology, Tadeusz Marciniak Lower Silesia Specialist Hospital-Emergency Medicine Center, Wroclaw, Poland; 2Faculty of Medicine, Wroclaw University of Science and Technology, Wroclaw, Poland; 3Division of Medical Biology, Faculty of Nursing and Midwifery, Wroclaw Medical University, Wroclaw, PolandCorrespondence: Bogusława Ołpińska, Department of Cardiology, Tadeusz Marciniak Lower Silesia Specialist Hospital-Emergency Medicine Center, Fieldorfa 2, Wroclaw, 54-049, Poland, Email [email protected]: Despite a growing evidence from the animal models of the cardioprotective function of the apelinergic system in the setting of myocardial infarction, little is known on the role of apelinergic system in the development of post- infarction adverse left ventricle remodeling in humans.Methods: The study group consisted of 49 patients with first-time ST-segment elevation myocardial infarction of anterior wall treated invasively. Echocardiography was performed on index hospitalization and on one-year check-up, with categorizing the study population into group with adverse LV remodeling defined as an increase of LV end diastolic volume by > 20% (n = 12) and the group without adverse remodeling (n = 29). ELA, AP-17, AP-13 and APJ receptor levels were measured on one-year follow-up.Results: Patients with adverse LV remodeling presented significantly higher plasma level of apelin-13 (85.63 [75.43– 96.13] vs 65.43 [57.35– 69.35], p = 0.001) and apelin-17 (69.36 [42.61– 77.04] vs 30.04 [25.97– 41.95], p = 0.004). In a univariable logistic regression analysis, higher LVEDV and LVEDV1, higher LVESV and LVESVi, lower LVEF, higher WMSI score, higher SYNTAX score, higher levels of hs-CRP during index hospitalization and higher levels of AP-13 and AP-17 on the one-year check-up were associated with adverse LV remodeling. In multivariable logistic regression analysis, only AP-17 level was independently associated with adverse LV remodeling (p = 0.050).Conclusion: Apelinergic system may be involved in the development of post- infarction adverse left ventricle remodeling.Keywords: apelin, myocardial infarction, adverse remodelin