A rapid and reliable determination of doxycycline hyclate by HPLC with UV detection in pharmaceutical samples

An accurate, sensitive and reproducible high performance liquid chromatographic (HPLC) method for the quantification of doxycycline hyclate in pharmaceutical samples has been developed and validated. The drug and the standard were eluted from a Lichrosorb RP-8 (250 mm´4.6 mm, 10 mm particle size) at 20 °C with a mobile phase consisting of methanol, acetonitrile and 0.010 M aqueous solution of oxalic acid (2:3:5, v/v/v). The flow rate was 1.25 ml min-1. A UV detector set at 350 nm was used to monitor the effluent. Each analysis required no longer than 4 min. The limits of detection and quantification were 1.15 and 3.84 μg ml-1, respectively. Recoveries for different concentrations ranged from 99.58 to 101.93 %

The Energy Value and Energy Yields of Alfalfa Forage Depending on the Cutting Time in Forage-Seed Production System

Economic importance of alfalfa (Medicago sativa L.) is reflected in the production of high-quality forage, however, the seeds of alfalfa are valuable commodity in the domestic and international markets. In Serbia, the seed is produced in forage-seed mode of exploitation where the second or third growth is used for seed production, and the remaining growths are used for fodder. The aim of this work was to determine the influence of cuttings and time of cutting on total energy value of hay in a model of forage and seed production. The second and third cuts were used as seed cut. In the variant where the second cut was used as seed cut, the first cut was harvested at different times (A1-early, A2-medium early, A3-late and A4- very late). In the model where the third cut was used for seed, two pre-cuts were used for forage production (A5). In all the following variants, seed cut was followed by one more cutting (final cut), used for the production of fodder. The highest average total production (from pre-cut and final cut) of NEL (34606 MJha-1) and NEM (33811 MJha-1) was realized in the system of cutting with two pre-cuts. In the variant with single pre-cut, the highest yield was formed in the early system. Later cutting of the first cut causes decline of NEL production and it was the lowest in the system of very late cutting or 15.1 % less than in the early system and 38% lower than in the system of cutting with two pre-cuts. Delaying of utilization of alfalfa to the later stages of exploitation has contributed to the lower yield of NEM and in the medium early system and late system and especially in the very late cutting system, where by 22.2 % less was realized than in the early production system. Studies have shown that late cutting of first cut resulted in the reduction of nutritional value expressed in the amount of net energy per unit area

Comparasion between European elite senior and junior female table tennis players

The aim of the study was to compare elite junior and senior women table tennis players, using three parameters of the table tennis: rally length, serve and receive analysis. Twentyfive junior and twenty-five elite senior matches were analysed (total: 263 sets and 4958 points) between players ranked in Top 25 in ETTU rankings in the last two years. All the athletes used an offensive style of play. The results of non-parametric Mann-Whitney U Test, showed a significantly higher rally length in senior compared to junior category (4.46 vs. 3.93). Moreover, the results of Pearson’s Chi-square tests show an association between the age categories and selected parameters (laterality, technique and placement) for both serve and receive. Different behavior between the two categories was noted. The senior players used more the flip technique (22.2 % vs 14.7 %) and short push to return the services of the opponents (32.5 % vs 26.0 %). These results provide useful information to analyze junior players’ behavior compared to the senior players in order to plan specific training sessions. It can be also useful to identify some parameters as predictors of the future success for junior players

Modeling affirmative and negated action processing in the brain with lexical and compositional semantic models

Recent work shows that distributional semantic models can be used to decode patterns of brain activity associated with individual words and sentence meanings. However, it is yet unclear to what extent such models can be used to study and ecode fMRI patterns associated with specific aspects of semantic composition such as the negation function. In this paper, we apply lexical and compositional semantic models to decode fMRI patterns associated with negated and affirmative sentences containing hand-action verbs. Our results show reduced decoding (correlation) of sentences where the verb is in the negated context, as compared to the affirmative one, within brain regions implicated in action-semantic processing. This supports behavioral and brain imaging studies, suggesting that negation involves reduced access to aspects of the affirmative mental representation. The results pave the way for testing alternate semantic models of negation against human semantic processing in the brain

Many analysts, one data set: making transparent how variations in analytic choices affect results

Twenty-nine teams involving 61 analysts used the same data set to address the same research question: whether soccer referees are more likely to give red cards to dark-skin-toned players than to light-skin-toned players. Analytic approaches varied widely across the teams, and the estimated effect sizes ranged from 0.89 to 2.93 (Mdn = 1.31) in odds-ratio units. Twenty teams (69%) found a statistically significant positive effect, and 9 teams (31%) did not observe a significant relationship. Overall, the 29 different analyses used 21 unique combinations of covariates. Neither analysts’ prior beliefs about the effect of interest nor their level of expertise readily explained the variation in the outcomes of the analyses. Peer ratings of the quality of the analyses also did not account for the variability. These findings suggest that significant variation in the results of analyses of complex data may be difficult to avoid, even by experts with honest intentions. Crowdsourcing data analysis, a strategy in which numerous research teams are recruited to simultaneously investigate the same research question, makes transparent how defensible, yet subjective, analytic choices influence research results

Hair-thread strangulation syndrome in childhood: a systematic review.

Hair-thread strangulation syndrome describes the constriction of a body part by a tightly wound hair or thread. This research aims to review the literature about this entity. A systematic review was performed to characterise hair-thread strangulation syndrome in subjects aged ≤16 years. This pre-registered review (PROSPERO ID: CRD42022363996) followed the PRISMA methodology. Subjects with digital strangulation were significantly younger (median = 4.0 [interquartile range: 2.0-6.1] months; n = 143) than females with genital strangulation (9.0 [6.8-11] years; n = 36), males with genital strangulation (5.1 [1.9-8.0] years; n = 36), and subjects with non-digital and non-genital strangulation (24 [13-48] months; n = 11). Digital strangulation was followed by an amputation in five (3.5%) and a reconstructive surgical intervention in seven (4.9%) cases. Sequelae occurred in four (11%) cases after female genital strangulation: clitoris autoamputation (n = 2) and surgical removal of a necrotic labium minus (n = 2). Severe complications were observed in 14 (39%) cases with male genital strangulation: urethral fistula (n = 7), urethral transection (n = 2), and partial penile autoamputation (n = 5). A partial uvular autoamputation was observed in one case (9.0%) with non-digital and non-genital strangulation. Early recognition and management are crucial to avoid sequelae or long-term care in hair-thread strangulation syndrome

Značaj atestiranja uređaja za aplikaciju sredstava za zaštitu bilja

In Serbia, since 1999, the Law on providing services in the field of plant protection which regulates mandatory inspection of sprayers and mist blowers in use. Plant protection law is to regulate the field of pesticide application. Pass laws are harmonized with the EU directive 91/414/EEC, and shall also include the article on mandatory inspection of sprayers and mist blowers. The main aim of the work is to inform and prepare the machines for users of plant protection products and control of the equipment and devices to pass the required control of technical accuracy of machines. The ways are given, organization and the results of mandatory inspection of sprayers in the developed European countriesU Srbiji od 1999 godine Zakonom o pružanju usluga u oblasti zaštite bilja predviđa se obavezna provera prskalica i orošivača kao i Zakonom o zaštiti bilja oblast primene pesticida se detaljnije reguliše. Doneti zakoni su usklađeni sa EU 91/414EEZ, i odnose se na obaveznu kontrolu prskalica i orošivača. Cilj rada je da informiše i pripremi korisnike mašina za zaštitu bilja, na obaveznu kontrolu tehničke ispravnosti. Navedeni su načini organizacije i neki rezultati obaveznog pregleda prskalica u razvijenim evropskim zemljama

Influence of antiferromagnetic spin ordering on the far-infrared active optical phonon modes of alpha-MnSe

The effects of spin-phonon interaction and magnetic anisotropy on the temperature dependence of the infrared optical phonon modes in the antiferromagnetic alpha-MnSe are investigated by use of Green’s function formalism within 1/z perturbation framework. The renormalization effects are calculated explicitly as a function of temperature, phonon-phonon, and spin-phonon interaction constants. Temperature dependence of the renormalized LO phonon frequencies of the F1u infrared active and combinational phonon modes are calculated and compared with experimental data. We have shown that the inclusion of anisotropy is necessary in order to get a good quantitative agreement with the experiment

Data from a pre-publication independent replication initiative examining ten moral judgement effects

We present the data from a crowdsourced project seeking to replicate findings in independent laboratories before (rather than after) they are published. In this Pre-Publication Independent Replication (PPIR) initiative, 25 research groups attempted to replicate 10 moral judgment effects from a single laboratory's research pipeline of unpublished findings. The 10 effects were investigated using online/lab surveys containing psychological manipulations (vignettes) followed by questionnaires. Results revealed a mix of reliable, unreliable, and culturally moderated findings. Unlike any previous replication project, this dataset includes the data from not only the replications but also from the original studies, creating a unique corpus that researchers can use to better understand reproducibility and irreproducibility in science

The pipeline project: Pre-publication independent replications of a single laboratory's research pipeline

This crowdsourced project introduces a collaborative approach to improving the reproducibility of scientific research, in which findings are replicated in qualified independent laboratories before (rather than after) they are published. Our goal is to establish a non-adversarial replication process with highly informative final results. To illustrate the Pre-Publication Independent Replication (PPIR) approach, 25 research groups conducted replications of all ten moral judgment effects which the last author and his collaborators had “in the pipeline” as of August 2014. Six findings replicated according to all replication criteria, one finding replicated but with a significantly smaller effect size than the original, one finding replicated consistently in the original culture but not outside of it, and two findings failed to find support. In total, 40% of the original findings failed at least one major replication criterion. Potential ways to implement and incentivize pre-publication independent replication on a large scale are discussed