Project management in the Apollo program Interim report

Project management in Apollo progra

Manned space flight in transition

A study was conducted to analyze the reorientation of NASA programs in the post-Apollo period. The study is an external view of NASA by unbiased observers as an input to and aid in the decision making process concerning near and long term planning. The subjects discussed are: (1) the near-term NASA scenario; (2) organization of field centers; (3) planning activities; and (4) operational activities. A summary of the recommendations arising as a result of the study is presented

Ratcheting of granular materials

We investigate the quasi-static mechanical response of soils under cyclic loading using a discrete model of randomly generated convex polygons. This response exhibits a sequence of regimes, each one characterized by a linear accumulation of plastic deformation with the number of cycles. At the grain level, a quasi-periodic ratchet-like behavior is observed at the contacts, which excludes the existence of an elastic regime. The study of this slow dynamics allows to explore the role of friction in the permanent deformation of unbound granular materials supporting railroads and streets.Comment: Changed content Submitted to Physical Review Letter

European Union - Reforms - Hungarian interests. What kind of European Union would we like?

The lecture deals with broad topics. First, it addresses some questions related to the current state of the EU integration regarding institutions and common policies. Second, it discusses the continued importance, the main results and hindering factors related to the Lisbon Programme, with a special emphasis on the educational system in Europe and Hungary. Third, the lecture deals with some possibilities in changing the EU’s rather limited external relation models to more flexible instruments

I RAPPORTI ECONOMICO-FINANZIARI TRA ITALIA E REPUBBLICA DI SAN MARINO

Circadian clocks coordinate 24-hr rhythms of behavior and physiology. In mammals, a master clock residing in the suprachiasmatic nucleus (SCN) is reset by the light-dark cycle, while timed food intake is a potent synchronizer of peripheral clocks such as the liver. Alterations in food intake rhythms can uncouple peripheral clocks from the SCN, resulting in internal desynchrony, which promotes obesity and metabolic disorders. Pancreas-derived hormones such as insulin and glucagon have been implicated in signaling mealtime to peripheral clocks. In this study, we identify a novel, more direct pathway of food-driven liver clock resetting involving oxyntomodulin (OXM). In mice, food intake stimulates OXM secretion from the gut, which resets liver transcription rhythms via induction of the core clock genes Per1 and 2. Inhibition of OXM signaling blocks food-mediated resetting of hepatocyte clocks. These data reveal a direct link between gastric filling with food and circadian rhythm phasing in metabolic tissues

Preservação e organização da geoinformação em instituições: o caso da construção da Infraestrutura de Dados Espaciais da Embrapa.

O objetivo deste trabalho é apresentar a estratégia da Embrapa para construir sua Infraestrutura de Dados Espaciais de forma a contribuir com o debate sobre a organização, preservação e integração de dados geoespaciais heterogêneos de acordo com as diretrizes federais estabelecidas pela INDE. Para esse fim, apresentaremos as etapas do processo interno realizado na Embrapa para elaboração o plano de adesão à INDE, o qual contou com a formação de um grupo de trabalho e, em seguida, descreveremos a estratégia elaborada

Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold

A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown

A Full Characterization of Quantum Advice

We prove the following surprising result: given any quantum state rho on n qubits, there exists a local Hamiltonian H on poly(n) qubits (e.g., a sum of two-qubit interactions), such that any ground state of H can be used to simulate rho on all quantum circuits of fixed polynomial size. In terms of complexity classes, this implies that BQP/qpoly is contained in QMA/poly, which supersedes the previous result of Aaronson that BQP/qpoly is contained in PP/poly. Indeed, we can exactly characterize quantum advice, as equivalent in power to untrusted quantum advice combined with trusted classical advice. Proving our main result requires combining a large number of previous tools -- including a result of Alon et al. on learning of real-valued concept classes, a result of Aaronson on the learnability of quantum states, and a result of Aharonov and Regev on "QMA+ super-verifiers" -- and also creating some new ones. The main new tool is a so-called majority-certificates lemma, which is closely related to boosting in machine learning, and which seems likely to find independent applications. In its simplest version, this lemma says the following. Given any set S of Boolean functions on n variables, any function f in S can be expressed as the pointwise majority of m=O(n) functions f1,...,fm in S, such that each fi is the unique function in S compatible with O(log|S|) input/output constraints.Comment: We fixed two significant issues: 1. The definition of YQP machines needed to be changed to preserve our results. The revised definition is more natural and has the same intuitive interpretation. 2. We needed properties of Local Hamiltonian reductions going beyond those proved in previous works (whose results we'd misstated). We now prove the needed properties. See p. 6 for more on both point