52 research outputs found

    Angiogenesis Markers Quantification in Breast Cancer and Their Correlation with Clinicopathological Prognostic Variables

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    Tumoural angiogenesis is essential for the growth and spread of breast cancer cells. Therefore the aim of this study was to assess the diagnostic performance of angiogenesis markers in tumours and there reflecting levels in serum of breast cancer patients. Angiogenin, Ang2, fibroblast growth factor basic, intercellular adhesion molecule (ICAM)-1, keratinocyte growth factor (KGF), platelet-derived growth factor-BB, and VEGF-A were measured using a FASTQuant angiogenic growth factor multiplex protein assay. We observed that breast cancer tumours exhibited high levels of PDGF-BB, bFGF and VEGF, and extremely high levels of TIMP-1 and Ang-2, whereas in serum we found significantly higher levels of Ang-2, PDGF-BB, bFGF, ICAM-1 and VEGF in patients with breast cancer compared to the benign breast diseases patients. Moreover, some of these angiogenesis markers evaluated in tumour and serum of breast cancer patients exhibited association with standard clinical parameters, ER status as well as MVD of tumours. Angiogenesis markers play important roles in tumour growth, invasion and metastasis. Our results suggest that analysis of angiogenesis markers in tumour and serum of breast cancer patients using multiplex protein assay can improve diagnosis and prognosis in this diseases

    Search for new phenomena using the invariant mass distribution of same-flavour opposite-sign dilepton pairs in events with missing transverse momentum in s√=13 TeV pp collisions with the ATLAS detector

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    aJUTS: s We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of EPLANET, ERC, ERDF, FP7, Horizon 2020 and Marie Skłodowska-Curie Actions, European Union; MINECO, Spain AND CERCA Programme Generalitat de Catalunya.A search for new phenomena in final states containing an or pair, jets, and large missing transverse momentum is presented. This analysis makes use of proton-proton collision data with an integrated luminosity of , collected during 2015 and 2016 at a centre-of-mass energy with the ATLAS detector at the Large Hadron Collider. The search targets the pair production of supersymmetric coloured particles (squarks or gluinos) and their decays into final states containing an or pair and the lightest neutralino () via one of two next-to-lightest neutralino () decay mechanisms: , where the Z boson decays leptonically leading to a peak in the dilepton invariant mass distribution around the Z boson mass; and with no intermediate resonance, yielding a kinematic endpoint in the dilepton invariant mass spectrum. The data are found to be consistent with the Standard Model expectation. Results are interpreted using simplified models, and exclude gluinos and squarks with masses as large as 1.85 and 1.3 at 95% confidence level, respectively

    Measurement of colour flow using jet-pull observables in in t(t)over-bar events with the ATLAS experiment at root s=13TeV

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    Previous studies have shown that weighted angular moments derived from jet constituents encode the colour connections between partons that seed the jets. This paper presents measurements of two such distributions, the jet-pull angle and jet-pull magnitude, both of which are derived from the jet-pull angular moment. The measurement is performed in tt¯ events with one leptonically decaying W boson and one hadronically decaying W boson, using 36.1fb−1 of pp collision data recorded by the ATLAS detector at s√=13TeV delivered by the Large Hadron Collider. The observables are measured for two dijet systems, corresponding to the colour-connected daughters of the W boson and the two b-jets from the top-quark decays, which are not expected to be colour connected. To allow the comparison of the measured distributions to colour model predictions, the measured distributions are unfolded to particle level, after correcting for experimental effects introduced by the detector. While good agreement can be found for some combinations of predictions and observables, none of the predictions describes the data well across all observables

    Search for electroweak production of supersymmetric particles in final states with two or three leptons at root s=13 Tev with the ATLAS detector

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    A search for the electroweak production of charginos, neutralinos and sleptons decaying into final states involving two or three electrons or muons is presented. The analysis is based on 36.1 fb−1 of √s = 13 TeV proton– proton collisions recorded by the ATLAS detector at the Large Hadron Collider. Several scenarios based on simplified models are considered. These include the associated production of the next-to-lightest neutralino and the lightest chargino, followed by their decays into final states with leptons and the lightest neutralino via either sleptons or Standard Model gauge bosons; direct production of chargino pairs, which in turn decay into leptons and the lightest neutralino via intermediate sleptons; and slepton pair production, where each slepton decays directly into the lightest neutralino and a lepton. No significant deviations from the Standard Model expectation are observed and stringent limits at 95% confidence level are placed on the masses of relevant supersymmetric particles in each of these scenarios. For a massless lightest neutralino, masses up to 580 GeV are excluded for the associated production of the next-to-lightest neutralino and the lightest chargino, assuming gauge-boson mediated decays, whereas for slepton-pair production masses up to 500 GeV are excluded assuming three generations of massdegenerate sleptons

    CLINICAL SIGNIFICANCE OF SERUM CAVEOLIN-1 LEVELS IN GASTRIC CANCER PATIENTS

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    Diagnostic value of the PSA subfractions, acid phosphatase and creatine kinase isoenzymes in prostate cancer

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    Prostate cancer is the second frequent cause of cancer among men. Prostate Specific Antigen ( PSA) is used widely for the diagnosis and during the follow-up of the patients as well as to distinguish prostatic hyperplasia from prostate cancer. However, PSA values above the reference range may be found also in nonmalignant conditions. Conversely, not all prostate cancers give rise to an elevated serum PSA concentration, Therefore, new and reliable parameters have been investigated. The ratio of free / total PSA has been found to distinguish between prostatic hyperplasia and carcinoma. It has been suggested that creatine kinase (CK) and acid phosphatase (ACP) isoenzymes may show significant variation in prostate cancer. In this study, free and total PSA levels and CK and ACP isoenzyme levels were investigated in patients with prostate cancer and prostatic hyperplasia, A significant difference between the ACP levels was found. Total PSA values were higher in cancer patients. The diagnostic sensitivity and specificity for prostatic cancer was clearly increased by considering the free / total PSA ratio. A higher specificitiy was achieved by the combination of the three parameters
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