Diagnostic Utility of the Impact of Event Scale-Revised in Two Samples of Survivors of War

The study aimed at examining the diagnostic utility of the Impact of Event Scale-Revised (IES-R) as a screening tool for post-traumatic stress disorder (PTSD) in survivors of war. The IES-R was completed by two independent samples that had survived the war in the Balkans: a sample of randomly selected people who had stayed in the area of former conflict (n = 3,313) and a sample of refugees to Western European countries (n = 854). PTSD was diagnosed using the MINI International Neuropsychiatric Interview. Prevalence of PTSD was 20.1% in the Balkan sample and 33.1% in the refugee sample. Results revealed that when considering a minimum value of specificity of 0.80, the optimally sensitive cut-off score for screening for PTSD in the Balkan sample was 34. In both the Balkan sample and the refugee sample, this cut-off score provided good values on sensitivity (0.86 and 0.89, respectively) and overall efficiency (0.81 and 0.79, respectively). Further, the kappa coefficients for sensitivity for the cut-off of 34 were 0.80 in both samples. Findings of this study support the clinical utility of the IES-R as a screening tool for PTSD in large-scale research studies and intervention studies if structured diagnostic interviews are regarded as too labor-intensive and too costly

Posttraumatic Stress Disorder and Associated Risk Factors in Canadian Peacekeeping Veterans with Health-Related Disabilities

Objectives: This study investigates posttraumatic stress disorder (PTSD) and its associated risk factors in a random, national, Canadian sample of United Nations peacekeeping veterans with service-related disabilities. Methods: Participants included 1016 male veterans (age \u3c 65 years) who served in the Canadian Forces from 1990 to 1999 and were selected from a larger random sample of 1968 veterans who voluntarily and anonymously completed a general health survey conducted by Veterans Affairs Canada in 1999. Survey instruments included the PTSD Checklist-Military Version (PCL-M), Center for Epidemiological Studies-Depression Scale (CES-D), and questionnaires regarding life events during the past year, current stressors, sociodemographic characteristics, and military history. Results: We found that rates of probable PTSD (PCL-M score \u3e 50) among veterans were 10.92% for veterans deployed once and 14.84% for those deployed more than once. The rates of probable clinical depression (CES-D score \u3e 16) were 30.35% for veterans deployed once and 32.62% for those deployed more than once. We found that, in multivariate analyses, probable PTSD rates and PTSD severity were associated with younger age, single marital status, and deployment frequency. Conclusions: PTSD is an important health concern in the veteran population. Understanding such risk factors as younger age and unmarried status can help predict morbidity among trauma-exposed veterans

Boredom proneness and fear of missing out mediate relations between depression and anxiety with problematic smartphone use

Depression and anxiety severity are found in numerous studies to correlate with increased levels of problematic smartphone use. Yet there are less available data on other psychopathology‐related correlates of such use. Two potentially important variables related to depression and anxiety, and recently found related to problematic smartphone use severity, are boredom proneness and the fear of missing out (FOMO). Our aims were to (a) assess boredom proneness and FOMO in relation to problematic smartphone use severity and (b) assess the mediating roles of boredom proneness and FOMO in relationships between depression/anxiety severity with problematic smartphone use severity. We recruited 297 American college students for a web survey, assessing constructs including FOMO, boredom proneness, depression, anxiety, problematic smartphone use, and smartphone use frequency. We tested a structural equation model to assess relations between depression and anxiety severity with boredom proneness and FOMO, and relations between these psychopathology constructs with levels of smartphone use frequency and problematic use. Results demonstrate that FOMO was significantly related to problematic smartphone use severity. FOMO also mediated relations between boredom proneness and problematic smartphone use severity. Furthermore, boredom proneness and FOMO serially mediated relations between both depression and anxiety severity with problematic smartphone use severity. Results are discussed in the context of Compensatory Internet Use Theory and the I‐PACE model in understanding factors driving problematic smartphone use.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153150/1/hbe2159.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153150/2/hbe2159_am.pd

Role of cellular senescence and NOX4-mediated oxidative stress in systemic sclerosis pathogenesis.

Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and numerous internal organs and a severe fibroproliferative vasculopathy resulting frequently in severe disability and high mortality. Although the etiology of SSc is unknown and the detailed mechanisms responsible for the fibrotic process have not been fully elucidated, one important observation from a large US population study was the demonstration of a late onset of SSc with a peak incidence between 45 and 54 years of age in African-American females and between 65 and 74 years of age in white females. Although it is not appropriate to consider SSc as a disease of aging, the possibility that senescence changes in the cellular elements involved in its pathogenesis may play a role has not been thoroughly examined. The process of cellular senescence is extremely complex, and the mechanisms, molecular events, and signaling pathways involved have not been fully elucidated; however, there is strong evidence to support the concept that oxidative stress caused by the excessive generation of reactive oxygen species may be one important mechanism involved. On the other hand, numerous studies have implicated oxidative stress in SSc pathogenesis, thus, suggesting a plausible mechanism in which excessive oxidative stress induces cellular senescence and that the molecular events associated with this complex process play an important role in the fibrotic and fibroproliferative vasculopathy characteristic of SSc. Here, recent studies examining the role of cellular senescence and of oxidative stress in SSc pathogenesis will be reviewed

The DSM-5 dissociative-PTSD subtype: Can levels of depression, anxiety, hostility, and sleeping difficulties differentiate between dissociative-PTSD and PTSD in rape and sexual assault victims?

The DSM-5 currently includes a dissociative-PTSD subtype within its nomenclature. Several studies have confirmed the dissociative-PTSD subtype in both American Veteran and American civilian samples. Studies have begun to assess specific factors which differentiate between dissociative vs. non-dissociative PTSD. The current study takes a novel approach to investigating the presence of a dissociative-PTSD subtype in its use of European victims of sexual assault and rape (N= 351). Utilizing Latent Profile Analyses, we hypothesized that a discrete group of individuals would represent a dissociative-PTSD subtype. We additionally hypothesized that levels of depression, anger, hostility, and sleeping difficulties would differentiate dissociative-PTSD from a similarly severe form of PTSD in the absence of dissociation. Results concluded that there were four discrete groups termed baseline, moderate PTSD, high PTSD, and dissociative-PTSD. The dissociative-PTSD group encompassed 13.1% of the sample and evidenced significantly higher mean scores on measures of depression, anxiety, hostility, and sleeping difficulties. Implications are discussed in relation to both treatment planning and the newly published DSM-5.</p

Fear of missing out is associated with disrupted activities from receiving smartphone notifications and surface learning in college students

Digital technologies, such as smartphones and tablets, can be useful in academic settings by allowing browsing for additional information, organizing the study process online, and facilitating communication between peers and instructors. On the other hand, several recent studies have shown that digital technology use can, in some circumstances, be negatively related to academic outcomes for some individuals. Fear of missing out (FOMO) could be one of these factors causing individual differences in how frequently people receive and react to interruptive notifications (INs). The aim of this study was to investigate how FOMO, the frequency of receiving INs, and stopping current activities due to INs, is associated with a surface approach to learning. Three hundred and sixteen U.S. university students responded to a web survey that included items regarding experiencing FOMO, the frequency of receiving INs and daily activity disruptions due to INs, and surface learning. Results showed that FOMO was associated with daily disrupted activities due to INs and surface learning, but not the frequency of receiving INs. Mediation analysis showed that the association between FOMO and surface learning was mediated by the frequency of daily disrupted activities due to INs. However, the nature of the sample somewhat restricts the generalizability of these results. The findings, their implications, and future directions are discussed

Posttraumatic Stress Disorder and Health-Related Quality of Life among a Sample of Treatment- and Pension-Seeking Deployed Canadian Forces Peacekeeping Veterans

Objectives: To examine the health-related quality of life (HRQOL) in deployed Canadian Forces peacekeeping veterans, addressing associations with posttraumatic stress disorder (PTSD), and depression severity. Methods: Participants (n = 125) were consecutive male veterans who were referred for a psychiatric assessment. Instruments administered included the Clinician-Administered PTSD Scale, Hamilton Depression Scale, Short-Form-36 Health Survey, and sociodemographic characteristics. Results: Mental HRQOL was significantly lower for peacekeepers with, than without, PTSD. Using univariate analyses, PTSD and depression severity were each significantly negatively related to mental HRQOL. In sequential regression analyses controlling for age, we found that PTSD and depression severity significantly predicted both mental and physical HRQOL. Conclusions: Veterans with PTSD have significant impairments in mental and physical HRQOL. This information is useful for clinicians and Veterans Affairs administrators working with the newer generation of veterans, as it stresses the importance of including measures of quality of life in the psychiatric evaluation of veterans to better address their rehabilitation needs