Superconductivity on the threshold of magnetism in CePd2Si2 and CeIn3

The magnetic ordering temperature of some rare earth based heavy fermion compounds is strongly pressure-dependent and can be completely suppressed at a critical pressure, p$_c$, making way for novel correlated electron states close to this quantum critical point. We have studied the clean heavy fermion antiferromagnets CePd$_2$Si$_2$ and CeIn$_3$ in a series of resistivity measurements at high pressures up to 3.2 GPa and down to temperatures in the mK region. In both materials, superconductivity appears in a small window of a few tenths of a GPa on either side of p$_c$. We present detailed measurements of the superconducting and magnetic temperature-pressure phase diagram, which indicate that superconductivity in these materials is enhanced, rather than suppressed, by the closeness to magnetic order.Comment: 11 pages, including 9 figure

Epidemic of illicit drug use, mechanisms of action/addiction and stroke as a health hazard

Drug abuse robs individuals of their jobs, their families, and their free will as they succumb to addiction; but may cost even more: a life of disability or even life lost due to stroke. Many illicit drugs have been linked to major cardiovascular events and other comorbidities, including cocaine, amphetamines, ecstasy, heroin, phencyclidine, lysergic acid diethylamide, and marijuana. This review focuses on available epidemiological data, mechanisms of action, particularly those leading to cerebrovascular events, and it is based on papers published in English in PubMed during 1950 through February 2011. Each drug's unique interactions with the brain and vasculature predispose even young, healthy people to ischemic or hemorrhagic stroke. Cocaine and amphetamines have the strongest association with stroke. However, the level of evidence firmly linking other drugs to stroke pathogenesis is weak. Large epidemiological studies and systematic evaluation of each drug's action on the brain and cardiovascular system are needed to reveal the full impact of drug use on the population

Rickettsia parkeri in Amblyomma americanum Ticks, Tennessee and Georgia, USA

To determine the geographic distribution of the newly recognized human pathogen Rickettsia parkeri, we looked for this organism in ticks from Tennessee and Georgia, USA. Using PCR and sequence analysis, we identified R. parkeri in 2 Amblyomma americanum ticks. This rickettsiosis may be underdiagnosed in the eastern United States

Purification and Characterization of Two New Allergens from the Venom of Vespa magnifica

Due to poor diagnostic facilities and a lack of medical alertness, allergy to Vespa wasps may be underestimated. Few allergens have been identified from Vespa wasps

Hyaluronidase of Bloodsucking Insects and Its Enhancing Effect on Leishmania Infection in Mice

Hyaluronidases are enzymes degrading the extracellular matrix of vertebrates. Bloodsucking insects use them to cleave the skin of the host, enlarge the feeding lesion and acquire the blood meal. In addition, resulting fragments of extracellular matrix modulate local immune response of the host, which may positively affect transmission of vector-borne diseases, including leishmaniasis. Leishmaniases are diseases with a wide spectrum of clinical forms, from a relatively mild cutaneous affection to life-threatening visceral disease. Their causative agents, protozoans of the genus Leishmania, are transmitted by phlebotomine sand flies. Sand fly saliva was described to enhance Leishmania infection, but the information about molecules responsible for this exacerbating effect is still very limited. In the present work we demonstrated hyaluronidase activity in salivary glands of various Diptera and in fleas. In addition, we showed that hyaluronidase exacerbates Leishmania lesions in mice and propose that salivary hyaluronidase may facilitate the spread of other vector-borne microorganisms

Team 12: Joint Dynamic Allocation of Fires and Sensors: Experimental Interface and Analysis

from Scythe : Proceedings and Bulletin of the International Data Farming Community, Issue 2 Workshop 14The Joint Dynamic Allocation of Fires and Sensors (JDAFS) simulation is a publicly available discrete event simulation that accounts for first order combat effects using Army approved algorithms. It couples dynamic allocation of resources such as unmanned platforms and artillery assets using optimization to a simulation to render better representations of network enabled warfare. The current configuration is not user friendly when entering the DOE factors. This is problematic for a number of reasons. First, the potential for data entry errors is significant when entering a large volume of numbers. Second, the data entry is not only time consuming but potentially expensive. Finally, an operator/analyst needs to be present as the runs are completed in order to start the next design point evolution. The potential for errors and the inherent inefficiencies warrant the development of a method to easily run a DOE if JDAFS is to be more widely used