The measurement postulates of quantum mechanics are operationally redundant

Understanding the core content of quantum mechanics requires us to disentangle the hidden logical relationships between the postulates of this theory. Here we show that the mathematical structure of quantum measurements, the formula for assigning outcome probabilities (Born's rule) and the post-measurement state-update rule, can be deduced from the other quantum postulates, often referred to as "unitary quantum mechanics", and the assumption that ensembles on finite-dimensional Hilbert spaces are characterised by finitely many parameters. This is achieved by taking an operational approach to physical theories, and using the fact that the manner in which a physical system is partitioned into subsystems is a subjective choice of the observer, and hence should not affect the predictions of the theory. In contrast to other approaches, our result does not assume that measurements are related to operators or bases, it does not rely on the universality of quantum mechanics, and it is independent of the interpretation of probability.Comment: This is a post-peer-review, pre-copyedit version of an article published in Nature Communications. The final authenticated version is available online at: http://dx.doi.org/10.1038/s41467-019-09348-

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

Funding This study was funded by the Medical Research Council (Grant number G0800149). Research material from this study is not available. Acknowledgement We are very grateful to Dr Robin A.J. Smith, Department of Chemistry, University of Otago, Dunedin, New Zealand, for the generous gifts of MitoE and MitoQ, without which this work would not have been possible.Peer reviewedPublisher PD

Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis

Funding The study was funded entirely by institutional funds.Peer reviewedPostprin

Effective-one-body waveforms for binary neutron stars using surrogate models

Gravitational-wave observations of binary neutron star systems can provide information about the masses, spins, and structure of neutron stars. However, this requires accurate and computationally efficient waveform models that take <1s to evaluate for use in Bayesian parameter estimation codes that perform 10^7 - 10^8 waveform evaluations. We present a surrogate model of a nonspinning effective-one-body waveform model with l = 2, 3, and 4 tidal multipole moments that reproduces waveforms of binary neutron star numerical simulations up to merger. The surrogate is built from compact sets of effective-one-body waveform amplitude and phase data that each form a reduced basis. We find that 12 amplitude and 7 phase basis elements are sufficient to reconstruct any binary neutron star waveform with a starting frequency of 10Hz. The surrogate has maximum errors of 3.8% in amplitude (0.04% excluding the last 100M before merger) and 0.043 radians in phase. The version implemented in the LIGO Algorithm Library takes ~0.07s to evaluate for a starting frequency of 30Hz and ~0.8s for a starting frequency of 10Hz, resulting in a speed-up factor of ~10^3 - 10^4 relative to the original Matlab code. This allows parameter estimation codes to run in days to weeks rather than years, and we demonstrate this with a Nested Sampling run that recovers the masses and tidal parameters of a simulated binary neutron star system.Comment: 17 pages, 11 figures, submitted to PR

Performance, Politics and Media: How the 2010 British General Election leadership debates generated ‘talk’ amongst the electorate.

During the British General Election 2010 a major innovation was introduced in part to improve engagement: a series of three live televised leadership debates took place where the leader of each of the three main parties, Labour, Liberal Democrat and Conservative, answered questions posed by members of the public and subsequently debated issues pertinent to the questions. In this study we consider these potentially ground breaking debates as the kind of event that was likely to generate discussion. We investigate various aspects of the ‘talk’ that emerged as a result of watching the debates. As an exploratory study concerned with situated accounts of the participants experiences we take an interpretive perspective. In this paper we outline the meta-narratives (of talk) associated with the viewing of the leadership debates that were identified, concluding our analysis by suggesting that putting a live debate on television and promoting and positioning it as a major innovation is likely to mean that is how the audience will make sense of it – as a media event

Finite size corrections to the radiation reaction force in classical electrodynamics

We introduce an effective field theory approach that describes the motion of finite size objects under the influence of electromagnetic fields. We prove that leading order effects due to the finite radius $R$ of a spherically symmetric charge is order $R^2$ rather than order $R$ in any physical model, as widely claimed in the literature. This scaling arises as a consequence of Poincar\'e and gauge symmetries, which can be shown to exclude linear corrections. We use the formalism to calculate the leading order finite size correction to the Abraham-Lorentz-Dirac force.Comment: 4 pages, 2 figure

Bench-to-bedside review : targeting antioxidants to mitochondria in sepsis

Peer reviewedPublisher PD

A nonlinear scalar model of extreme mass ratio inspirals in effective field theory I. Self force through third order

The motion of a small compact object in a background spacetime is investigated in the context of a model nonlinear scalar field theory. This model is constructed to have a perturbative structure analogous to the General Relativistic description of extreme mass ratio inspirals (EMRIs). We apply the effective field theory approach to this model and calculate the finite part of the self force on the small compact object through third order in the ratio of the size of the compact object to the curvature scale of the background (e.g., black hole) spacetime. We use well-known renormalization methods and demonstrate the consistency of the formalism in rendering the self force finite at higher orders within a point particle prescription for the small compact object. This nonlinear scalar model should be useful for studying various aspects of higher-order self force effects in EMRIs but within a comparatively simpler context than the full gravitational case. These aspects include developing practical schemes for higher order self force numerical computations, quantifying the effects of transient resonances on EMRI waveforms and accurately modeling the small compact object's motion for precise determinations of the parameters of detected EMRI sources.Comment: 30 pages, 8 figure

Theory of optomechanics: Oscillator-field model of moving mirrors

In this paper we present a model for the kinematics and dynamics of optomechanics which describe the coupling between an optical field, here modeled by a massless scalar field, and the internal (e.g., determining its reflectivity) and mechanical (e.g., displacement) degrees of freedom of a moveable mirror. As opposed to implementing boundary conditions on the field we highlight the internal dynamics of the mirror which provides added flexibility to describe a variety of setups relevant to current experiments. The inclusion of the internal degrees of freedom in this model allows for a variety of optical activities of mirrors from those exhibiting broadband reflective properties to the cases where reflection is suppressed except for a narrow band centered around the characteristic frequency associated with the mirror's internal dynamics. After establishing the model and the reflective properties of the mirror we show how appropriate parameter choices lead to useful optomechanical models such as the well known Barton-Calogeracos model [G. Barton and A. Calogeracos, Ann. Phys. 238, 227 (1995)] and the important yet lesser explored nonlinear models (e.g., $Nx$ coupling) for small photon numbers $N$, which present models based on side-band approximations [H. Kimble et al., Phys. Rev. D 65, 022002 (2001)] cannot cope with. As a simple illustrative application we consider classical radiation pressure cooling with this model. To expound its theoretical structure and physical meanings we connect our model to field-theoretical models using auxiliary fields and the ubiquitous Brownian motion model of quantum open systems. Finally we describe the range of applications of this model, from a full quantum mechanical treatment of radiation pressure cooling, quantum entanglement between macroscopic mirrors, to the backreaction of Hawking radiation on black hole evaporation in a moving mirror analog.Comment: 27 pages, 3 figure

A Numerical Relativity Waveform Surrogate Model for Generically Precessing Binary Black Hole Mergers

A generic, non-eccentric binary black hole (BBH) system emits gravitational waves (GWs) that are completely described by 7 intrinsic parameters: the black hole spin vectors and the ratio of their masses. Simulating a BBH coalescence by solving Einstein's equations numerically is computationally expensive, requiring days to months of computing resources for a single set of parameter values. Since theoretical predictions of the GWs are often needed for many different source parameters, a fast and accurate model is essential. We present the first surrogate model for GWs from the coalescence of BBHs including all $7$ dimensions of the intrinsic non-eccentric parameter space. The surrogate model, which we call NRSur7dq2, is built from the results of $744$ numerical relativity simulations. NRSur7dq2 covers spin magnitudes up to $0.8$ and mass ratios up to $2$, includes all $\ell \leq 4$ modes, begins about $20$ orbits before merger, and can be evaluated in $\sim~50\,\mathrm{ms}$. We find the largest NRSur7dq2 errors to be comparable to the largest errors in the numerical relativity simulations, and more than an order of magnitude smaller than the errors of other waveform models. Our model, and more broadly the methods developed here, will enable studies that would otherwise require millions of numerical relativity waveforms, such as parameter inference and tests of general relativity with GW observations.Comment: 10 pages, 5 figures; Added report numbe