Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels

PMCID: PMC3480949This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Updates on the bryophyte flora of the lowland Woods and temporary ponds west of Lake Trasimeno (Central Italy).

A study of the bryophytes of the lowlands west of Lake Trasimeno, a very peculiar territory for its geological, biogeographical and bioclimatic traits, was carried out. The data here reported were collected in a mosaic of woods and Mediterranean temporary ponds, the latter indicated as priority natural habitats under the Habitats Directive 92/43/EEC with the code 3170*. Research led to the identification of 44 taxa of bryophytes (13 liverworts and 31 mosses), among which 5 liverwort and 8 moss species are new records for the Umbria region, while one is confirmed. Particularly interesting is the presence of 13 liverwort taxa considered, according to the European Committee for Conservation of Bryophytes (ECCB), under threat at different levels in Europe. The study offers new outcomes on neglected aspects of the flora of central Italy and represents a considerable improvement of the floristic, biogeographical and ecological understanding of its bryophytic component

Bryophytic vegetation of fragile and threatened ecosystems: the case of the Mediterranean temporary ponds in inland Central Italy.

The first overview of the bryophytic vegetation of the Mediterranean temporary ponds in Umbria region is reported. Phytosociological relevés were carried out in a scattered system of ephemeral pools, where seasonal fluctuation in the water level is the main driving factor. By applying Braun-Blanquet's approach to sample the bryo-communities and multivariate analysis tools to analyse data, the identification of some bryophyte communities was possible, one of which is here described as new association. It is Entosthodono fascicularidis-Archidietum alternifolii ass. nova, referable to the class Psoretea decipientis. The other bryo-communities have been framed into the classes Cladonio digitatae-Lepidozietea reptantis, Ceratodonto purpurei-Polytrichetea piliferii and Psoretea decipientis again

La riabilitazione termale nel 150° Anniversario dell'Unità d'Italia. Un testimonial d'eccezione: Giuseppe Garibaldi.

Nell’anno in cui si celebra il 150° Anniversario dell’Unità d’Italia, il riemergere di alcune lettere di Giuseppe Garibaldi - che fanno riferimento ad un periodo di cure termali effettuato presso le Terme della Ficoncella e di Traiano (vicino Civitavecchia, Roma) - ci ha dato lo spunto per questo lavoro che intende considerare i numerosi trattamenti effettuati presso diverse stazioni termali italiane dall’Eroe dei Due Mondi per una patologia reumatica (probabilmente una poliartrite reumatoide) e per gli esiti di varie ferite di guerra, in particolare la ben nota ferita da arma da fuoco subita a livello dell’arto inferiore destro nel corso della battaglia d’Aspromonte, nel 1862

Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis.

BACKGROUND: Carotid intima-media thickness (CIMT), a subclinical measure of atherosclerosis, is associated with risk of coronary heart disease events. Statins reduce progression of CIMT and coronary heart disease risk in proportion to the reduction in low-density lipoprotein cholesterol. However, interventions targeting triglycerides (TGs) or high-density lipoprotein cholesterol (HDL-C) have produced inconsistent effects on CIMT and coronary heart disease risk, making it uncertain whether such agents are ineffective for coronary heart disease prevention or whether CIMT is an inadequate marker of HDL-C or TG-mediated effects. We aimed to determine the causal association among the 3 major blood lipid fractions and common CIMT using mendelian randomization analysis. METHODS AND RESULTS: Genetic scores specific for low-density lipoprotein cholesterol, HDL-C, and TGs were derived based on single nucleotide polymorphisms from a gene-centric array in ≈5000 individuals (Cardiochip scores) and from a genome-wide association meta-analysis in >100 000 individuals (Global Lipids Genetic Consortium scores). These were used as instruments in a mendelian randomization analysis in 2 prospective cohort studies. A genetically predicted 1 mmol/L higher low-density lipoprotein cholesterol concentration was associated with a higher common CIMT by 0.03 mm (95% confidence interval, 0.01-0.04) and 0.04 mm (95% confidence interval, 0.02-0.06) based on the Cardiochip and Global Lipids Genetic Consortium scores, respectively. HDL-C and TGs were not causally associated with CIMT. CONCLUSIONS: Our findings confirm a causal relationship between low-density lipoprotein cholesterol and CIMT but not with HDL-C and TGs. At present, the suitability of CIMT as a surrogate marker in trials of cardiovascular therapies targeting HDL-C and TGs is questionable and requires further study

Maternal depression and anxiety predicts the pattern of offspring symptoms during their transition to adulthood

Background. Episodes of depression and anxiety (D&A) during the transition from late adolescence to adulthood, particularly when persistent, are predictive of long-term disorders and associated public health burden. Understanding risk factors at this time is important to guide intervention. The current objective was to investigate the associations between maternal symptoms of D&A with offspring symptoms during their transition to adulthood. Method. Data from a large population-based birth cohort study, in South Brazil, were used. Prospective associations between maternal D&A and offspring risk of these symptoms during the transition to adulthood (18/19, 24 and 30 years) were estimated. Results. Maternal D&A in adolescence was associated with offspring symptoms across the transition to adulthood, associations were consistently stronger for females than for males. Daughters whose mothers reported D&A were 4.6 times (95% confidence interval 2.71–7.84) as likely to report D&A at all three time-points, than daughters of symptom-free mothers. Conclusions. Maternal D&A is associated with persistent D&A during the daughter’s transition to adulthood. Intervention strategies should consider the mother’s mental health

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration

AIMS: To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association study-derived lipid-associated SNPs with other risk factors and CHD events. METHODS AND RESULTS: Using two case–control studies, three cross-sectional, and seven prospective studies with up to 25 000 individuals and 5794 CHD events we evaluated associations of 34 genome-wide-association study-identified SNPs with CHD risk and 16 CHD-associated risk factors or biomarkers. The Ch9p21 SNPs rs1333049 (OR 1.17; 95% confidence limits 1.11–1.24) and rs10757274 (OR 1.17; 1.09–1.26), MIA3 rs17465637 (OR 1.10; 1.04–1.15), Ch2q36 rs2943634 (OR 1.08; 1.03–1.14), APC rs383830 (OR 1.10; 1.02, 1.18), MTHFD1L rs6922269 (OR 1.10; 1.03, 1.16), CXCL12 rs501120 (OR 1.12; 1.04, 1.20), and SMAD3 rs17228212 (OR 1.11; 1.05, 1.17) were all associated with CHD risk, but not with the CHD biomarkers and risk factors measured. Among the 20 blood lipid-related SNPs, LPL rs17411031 was associated with a lower risk of CHD (OR 0.91; 0.84–0.97), an increase in Apolipoprotein AI and HDL-cholesterol, and reduced triglycerides. SORT1 rs599839 was associated with CHD risk (OR 1.20; 1.15–1.26) as well as total- and LDL-cholesterol, and apolipoprotein B. ANGPTL3 rs12042319 was associated with CHD risk (OR 1.11; 1.03, 1.19), total- and LDL-cholesterol, triglycerides, and interleukin-6. CONCLUSION: Several SNPs predicting CHD events appear to involve pathways not currently indexed by the established or emerging risk factors; others involved changes in blood lipids including triglycerides or HDL-cholesterol as well as LDL-cholesterol. The overlapping association of SNPs with multiple risk factors and biomarkers supports the existence of shared points of regulation for these phenotypes

Taming troubled teens: The social production of mental morbidity amongst young mothers in Pelotas, Brazil

Copyright @ 2011 Elsevier Ltd. This is a post-print version of the article. The published version of the article can be viewed at the link below.Explanations for the association between teen-childbearing and subsequent mental morbidity vary considerably, from those based on neurological theories of development to those investigating underlying social and economic determinants. Based on longitudinal epidemiological and ethnographic sub-studies of the 1982 Pelotas birth cohort study, this paper explores the hypothesis that teen childbearing and subsequent mental morbidity have become associated through the interplay of culture, society, and biology in situations where teen pregnancy has become a stigmatised object of scientific and public health attention. Results show that the effect of teen childbearing on subsequent mental morbidity remained significant in the multivariate analysis. Ethnographic analysis, together with epidemiological effect modification analyses, suggest that this association is partially accounted for by the fact that it is more pronounced amongst a specific subgroup of women of low socio-economic status who, being more politicised about societal injustice, were also more critically engaged with – and thus troubled by – the inequitable institutionalisation of life-cycle transitions. With time, these women became highly critical of the institutionalised identification of early childbearing as a key violation of life-cycle norms and the differential class-based application of scientific knowledge on its causes and consequences. Public health campaigns should consider how the age-based institutionalisation of developmental norms has enabled the stigmatisation of those identified as transgressors.The 1982 cohort study has been funded by The Wellcome Trust, the World Health Organisation, the PanAmerican Health Organisation, the European Union, the Programa Nacional para Centros de Excelência (PRONEX), the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), the Brazilian Ministry of Health, and the Fundação de Amparo à Pesquisa do Rio Grande do Sul (Fapergs). D Béhague received support from a US National Science Foundation Doctoral Fellowship and a Postdoctoral Training Fellowship from The Wellcome Trust (Grant no. GR077175MA)