Long-term follow-up of Philadelphia chromosome-positive (Ph+) chronic myeloid leukaemia (CML) in children and adolescents managed at a single institution over a 20-year period

Chronic myeloid leukaemia (CML) is rare in childhood. In our Institution we managed 30 consecutive Ph+CML patients aged <18 years, according to our adults’ guidelines. Patients with HLA-identical related donor (RD) underwent stem cell transplant (SCT). Since 1989, patients without RD were systematically treated with -interferon (IFN) (median dosage: 6 MU/day). Of 18/19 evaluable patients, 17 (94.5%) achieved haematologic response (HR), 11/17 (65%) cytogenetic response (CyR), complete (CCyR) in 4 (23.5%). Three patients remain in CCyR, 2 achieved BCR-ABL transcript disappearance. Of 13 patients without CCyR, 5 underwent SCT, 4 switched to STI571, 4 progressed. All patients receiving STI571 in chronic phase (CP) obtained sustained CCyR and 3 a persistent molecular response. 8-year survival among IFN-treated patients, censored or not for subsequent therapies, is 62% and 63%. Overall, 13/30 patients underwent SCT: 5 HLA-identical-RD, 5 matched unrelated donor, 2 mismatched-RD, 1 unrelated mismatched umbilical cord blood. Eight allotransplanted patients (6/6 in 1st CP) are in cytogenetic and molecular remission with 8-year survival of 61% from SCT and 69% from diagnosis. In our 20-year experience, the use of IFN in children without matched RD led to prolonged cytogenetic and molecular responses and long-term survival, without impairing the outcome of subsequent SCT

Chronic bacterial prostatitis: efficacy of short-lasting antibiotic therapy with prulifloxacin (Unidrox®) in association with saw palmetto extract, lactobacillus sporogens and arbutin (Lactorepens®)

Bacterial prostatitis (BP) is a common condition accounting responsible for about 5-10% of all prostatitis cases; chronic bacterial prostatitis (CBP) classified as type II, are less common but is a condition that significantly hampers the quality of life, (QoL) because not only is it a physical condition but also a psychological distress. Commonly patients are treated with antibiotics alone, and in particular fluoroquinolones are suggested by the European Urology guidelines. This approach, although recommended, may not be enough. Thus, a multimodal approach to the prolonged antibiotic therapy may be helpful.210 patients affected by chronic bacterial prostatitis were enrolled in the study. All patients were positive to Meares-Stamey test and symptoms duration was &gt; 3&nbsp;months. The purpose of the study was to evaluate the efficacy of a long lasting therapy with a fluoroquinolone in association with a nutraceutical supplement (prulifloxacin 600&nbsp;mg for 21&nbsp;days and an association of Serenoa repens 320&nbsp;mg, Lactobacillus Sporogens 200&nbsp;mg, Arbutin 100&nbsp;mg for 30&nbsp;days). Patients were randomized in two groups (A and B) receiving respectively antibiotic alone and an association of antibiotic plus supplement.Biological recurrence at 2&nbsp;months in Group A was observed in 21 patients (27.6%) and in Group B in 6 patients (7.8%). Uropathogens found at the first follow-up were for the majority Gram - (E. coli and Enterobacter spp.). A statistically significant difference was found at the time of the follow-up between Group A and B in the NIH-CPSI questionnaire score, symptoms evidence and serum PSA.Broad band, short-lasting antibiotic therapy in association with a nutritional supplement (serenoa repens, lactobacillus sporogens and arbutin) show better control and recurrence rate on patients affected by chronic bacterial prostatitits in comparison with antibiotic treatment alone.NCT02130713Date of trial Registration: 30/04/2014

Quantum dilaton gravity as a linear dilaton conformal field theory

A model of matter-coupled gravity in two dimensions is quantized. The crucial requirement for performing the quantization is the vanishing of the conformal anomaly, which is achieved by tuning a parameter in the interaction potential. The spectrum of the theory is determined by mapping the model first onto a field theory with a Liouville interaction, then onto a linear dilaton conformal field theory. In absence of matter fields a pure gauge theory with massless ground state is found; otherwise it is possible to minimally couple up to 11 matter scalar fields: in this case the ground state is tachyonic and the matter sector decouples, like the transverse oscillators in the critical bosonic string.Comment: 7 pages, RevTeX4 file. v2: some comments and one reference adde

Microscopic unitary description of tidal excitations in high-energy string-brane collisions

The eikonal operator was originally introduced to describe the effect of tidal excitations on higher-genus elastic string amplitudes at high energy. In this paper we provide a precise interpretation for this operator through the explicit tree-level calculation of generic inelastic transitions between closed strings as they scatter off a stack of parallel Dp-branes. We perform this analysis both in the light-cone gauge, using the Green-Schwarz vertex, and in the covariant formalism, using the Reggeon vertex operator. We also present a detailed discussion of the high energy behaviour of the covariant string amplitudes, showing how to take into account the energy factors that enhance the contribution of the longitudinally polarized massive states in a simple way.Comment: 58 page

An integrative evolutionary framework for psychopathology

The field of psychopathology is in a transformative phase, and is witnessing a renewed surge of interest in theoretical models of mental disorders. While many interesting proposals are competing for attention in the literature, they tend to focus narrowly on the proximate level of analysis and lack a broader understanding of biological function. In this paper, we present an integrative framework for mental disorders built on concepts from life history theory, and describe a taxonomy of mental disorders based on its principles, the fast–slow– defense model (FSD). The FSD integrates psychopathology with normative individual differences in personality and behavior, and allows researchers to draw principled distinctions between broad clusters of disorders, as well as identify functional subtypes within current diagnostic categories. Simulation work demonstrates that the model can explain the large-scale structure of comorbidity, including the apparent emergence of a general “p factor” of psychopathology. A life history approach also provides novel integrative insights into the role of environmental risk/protective factors and the developmental trajectories of various disorders

Black Hole Evaporation along Macroscopic Strings

We develop the quantization of a macroscopic string which extends radially from a Schwarzschild black hole. The Hawking process excites a thermal bath of string modes that causes the black hole to lose mass. The resulting typical string configuration is a random walk in the angular coordinates. We show that the energy flux in string excitations is approximately that of spacetime field modes.Comment: 26pp, EFI 93-73. (Original claim that string Hawking flux exceeds spacetime flux is WRONG. It is the same; revised version provides correct argument and additional comments.

Transplanckian Collisions at the LHC and Beyond

Elastic collisions in the transplanckian region, where the center-of-mass energy is much larger than the fundamental gravity mass scale, can be described by linearized general relativity and known quantum-mechanical effects as long as the momentum transfer of the process is sufficiently small. For larger momentum transfer, non-linear gravitational effects become important and, although a computation is lacking, black-hole formation is expected to dominate the dynamics. We discuss how elastic transplanckian collisions can be used at high-energy colliders to study, in a quantitative and model-independent way, theories in which gravity propagates in flat extra dimensions. At LHC energies, however, incalculable quantum-gravity contributions may significantly affect the experimental signal.Comment: 45 pages, 9 figures. v2: added refs and expanded discussion of fixed-angle string scatterin

Biallelic BIRC3 inactivation in chronic lymphocytic leukaemia patients with 11q deletion identifies a subgroup with very aggressive disease.

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Efficacy and safety of Finasteride (5 alpha-reductase inhibitor) monotherapy in patients with benign prostatic hyperplasia: A critical review of the literature

BACKGROUND: Combination therapy with 5 alpha-reductase inhibitor (5-ARI) and alpha-blocker can be considered as a gold standard intervention for medical management of lower urinary tract symptoms related to benign prostatic hyperplasia (LUTS/BPH). On the other hand, 5-ARI monotherapy and in particular Finasteride alone is currently getting focus of attention especially due to lack of systematic reviews investigating efficacy outcomes and/or adverse events associated. OBJECTIVES: Aim of the present critical review was to analyze current knowledge of clinical efficacy and incidence of adverse events associated with 5-ARI treatment for LUTS/BPH. MATERIALS AND METHODS: A systematic review of clinical trials of the literature of the past 20 years was performed using database from PubMed, Cochrane Collaboration and Embase. A total of 8821 patients were included in this study and inclusion criteria for studies selection were: data from randomized clinical trials (RCTs) focusing their attention on the clinical role of Finasteride monotherapy for symptomatic BPH. Parameters of research included prostate specific antigen (PSA), prostate volume (PV), International Prostate Symptom Score (IPPS), postvoid residual urine (PVR), voiding symptoms of IPSS (voiding IPSS), maximum urinary flow rate (Qmax), and adverse events (AEs). RESULTS: Overall 12 original articles were included and critically evaluated. Sample sizes of patient actively treated with finasteride varied from 13 to 1524 cases analyzed in a single study. Follow-up after treatments ranged from 3 to 54 months. The effect of finasteride in reducing prostate volume (PV) was moderate (standardized mean difference (SMD) effect between 0.5 to 0.8 for all trials evaluable) while the effect on IPSS score and Qmax was considered significant (SMD in the 0.2 to 0.5 variation range). No severe AEs and/or psychiatric disorders were retrieved among the studies. Sexual health dysfunctions were significantly influenced by finasteride therapy when compared with placebo treated patients. CONCLUSIONS: Although significant clinical benefits of finasteride monotherapy were demonstrated, the effective size of the available reports included in the analysis is limited. Additional head-to-head studies would be needed to re-evaluate clinical efficacy and safety of 5-ARI in combination or not with alpha blockers

The Fayet-Iliopoulos D-term and its renormalisation in the MSSM

We consider the renormalisation of the Fayet-Iliopoulos D-term in a softly-broken supersymmetric gauge theory with a non-simple gauge group containing an abelian factor, and present the associated beta-function through three loops. We also include in an appendix the result for several abelian factors. We specialise to the case of the minimal supersymmetric standard model (MSSM), and investigate the behaviour of the Fayet-Iliopoulos coupling for various boundary conditions at the unification scale. We focus particularly on the case of non-standard soft supersymmetry breaking couplings, for which the Fayet-Iliopoulos coupling evolves significantly between the unification scale and the weak scale.Comment: 18 pages, Revtex, 2 figures. Expanded version including general results for gauge groups with several abelian factors. Minor typos correcte