Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Current and advanced act control system definition study. Volume 2: Appendices

The current status of the Active Controls Technology (ACT) for the advanced subsonic transport project is investigated through analysis of the systems technical data. Control systems technologies under examination include computerized reliability analysis, pitch axis fly by wire actuator, flaperon actuation system design trade study, control law synthesis and analysis, flutter mode control and gust load alleviation analysis, and implementation of alternative ACT systems. Extensive analysis of the computer techniques involved in each system is included

Lower and upper probabilities in the distributive lattice of subsystems

yesThe set of subsystems ∑ (m) of a finite quantum system ∑(n) (with variables in Ζ(n)) together with logical connectives, is a distributive lattice. With regard to this lattice, the ℓ(m | ρn) = Tr ((m) ρn ) (where (m) is the projector to ∑(m)) obeys a supermodularity inequality, and it is interpreted as a lower probability in the sense of the Dempster–Shafer theory, and not as a Kolmogorov probability. It is shown that the basic concepts of the Dempster–Shafer theory (lower and upper probabilities and the Dempster multivaluedness) are pertinent to the quantum formalism of finite systems

Activating Generalized Fuzzy Implications from Galois Connections

This paper deals with the relation between fuzzy implications and Galois connections, trying to raise the awareness that the fuzzy implications are indispensable to generalise Formal Concept Analysis. The concrete goal of the paper is to make evident that Galois connections, which are at the heart of some of the generalizations of Formal Concept Analysis, can be interpreted as fuzzy incidents. Thus knowledge processing, discovery, exploration and visualization as well as data mining are new research areas for fuzzy implications as they are areas where Formal Concept Analysis has a niche.F.J. Valverde-Albacete—was partially supported by EU FP7 project LiMoSINe, (contract 288024). C. Peláez-Moreno—was partially supported by the Spanish Government-CICYT project 2011-268007/TEC.Publicad

The impact of detergents on the tissue decellularization process: a ToF-SIMS study

Biologic scaffolds are derived from mammalian tissues, which must be decellularized to remove cellular antigens that would otherwise incite an adverse immune response. Although widely used clinically, the optimum balance between cell removal and the disruption of matrix architecture and surface ligand landscape remains a considerable challenge. Here we describe the use of time of flight secondary ion mass spectroscopy (ToF-SIMS) to provide sensitive, molecular specific, localized analysis of detergent decellularized biologic scaffolds. We detected residual detergent fragments, specifically from Triton X-100, sodium deoxycholate and sodium dodecyl sulphate (SDS) in decellularized scaffolds; increased SDS concentrations from 0.1% to 1.0% increased both the intensity of SDS fragments and adverse cell outcomes. We also identified cellular remnants, by detecting phosphate and phosphocholine ions in PAA and CHAPS decellularized scaffolds. The present study demonstrates ToF-SIMS is not only a powerful tool for characterization of biologic scaffold surface molecular functionality, but also enables sensitive assessment of decellularization efficacy

Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Current and advanced act control system definition study, volume 1

An active controls technology (ACT) system architecture was selected based on current technology system elements and optimal control theory was evaluated for use in analyzing and synthesizing ACT multiple control laws. The system selected employs three redundant computers to implement all of the ACT functions, four redundant smaller computers to implement the crucial pitch-augmented stability function, and a separate maintenance and display computer. The reliability objective of probability of crucial function failure of less than 1 x 10 to the -9th power per flight of 1 hr can be met with current technology system components, if the software is assumed fault free and coverage approaching 1.0 can be provided. The optimal control theory approach to ACT control law synthesis yielded comparable control law performance much more systematically and directly than the classical s-domain approach. The ACT control law performance, although somewhat degraded by the inclusion of representative nonlinearities, remained quite effective. Certain high-frequency gust-load alleviation functions may require increased surface rate capability

αI-spectrin represents evolutionary optimization of spectrin for red blood cell deformability

Spectrin tetramers of the membranes of enucleated mammalian erythrocytes play a critical role in red blood cell survival in circulation. One of the spectrins, αI, emerged in mammals with enucleated red cells following duplication of the ancestral α-spectrin gene common to all animals. The neofunctionalized αIspectrin has moderate affinity for βI-spectrin, while αII-spectrin, expressed in non-erythroid cells, retains ancestral characteristics and has a 10-fold higher affinity for βI-spectrin. It has been hypothesized that this adaptation allows for rapid make-and-break of tetramers to accommodate membrane deformation. We have tested this hypothesis by generating mice with high-affinity spectrin tetramers formed by exchanging the site of tetramer formation in αI-spectrin (segments R0 and R1) for that of αII-spectrin. Erythrocytes with αIIβI presented normal hematologic parameters yet showed increased thermostability and their membranes were significantly less deformable: under low shear forces they displayed tumbling behavior, rather than tank-treading. The membrane skeleton is more stable with αIIβI and shows significantly less remodeling under deformation than red cell membranes of wild-type mice. These data demonstrate that spectrin tetramers undergo remodeling in intact erythrocytes and that this is required for the normal deformability of the erythrocyte membrane. We conclude that αI-spectrin represents evolutionary optimization of tetramer formation: neither higher affinity tetramers (as shown here) nor lower affinity (as seen in hemolytic disease), can support the membrane properties required for effective tissue oxygenation in circulation

Kapitel 8. Landnutzung und Klimawandel im Kontext der Nachhaltigen Entwicklungsziele

Dieses Kapitel präsentiert und bewertet den aktuellen Stand des Wissens zum Konnex Landnutzung und Klimawandel in Österreich aus dem systemischen Blickwinkel der UN Agenda 2030 für eine Nachhaltige Entwicklung. Dabei wird dem Thema entsprechend auf die Verflechtungen zwischen den lokalen, nationalen und internationalen Ebenen eingegangen. Die Menschheit befindet sich in kritischen, vielfältigen und vernetzten Krisen. Integrative und globale Lösungsansätze, wie sie in der Agenda 2030 festgeschrieben sind, haben für diese multiplen Krisen ein hohes Lösungspotenzial

Introducing the INSIGNIA project: environmental monitoring of pesticide use through honey bees

INSIGNIA aims to design and test an innovative, non-invasive, scientifically proven citizen science environmental monitoring protocol for the detection of pesticides by honey bees. It is a 30-month pilot project initiated and financed by the EC (PP-1-1-2018; EC SANTE). The study is being carried out by a consortium of specialists in honey bees, apiculture, statistics, analytics, modelling, extension, social science and citizen science from twelve countries. Honey bee colonies are excellent bio-samplers of biological material such as nectar, pollen and plant pathogens, as well as non-biological material such as pesticides or airborne contamination. Honey bee colonies forage over a circle of 1 km radius, increasing to several km if required, depending on the availability and attractiveness of food. All material collected is accumulated in the hive.The honey bee colony can provide four main matrices for environmental monitoring: bees, honey, pollen and wax. Because of the non-destructive remit of the project, for pesticides, pollen is the focal matrix and used as trapped pollen and beebread in this study. Although beeswax can be used as a passive sampler for pesticides, this matrix is not being used in INSIGNIA because of its polarity dependent absorbance, which limits the required wide range of pesticides to be monitored. Alternatively, two innovative non-biological matrices are being tested: i) the “Beehold tube”, a tube lined with the generic absorbent polyethylene-glycol PEG, through which hive-entering bees are forced to pass, and ii) the “APIStrip” (Absorbing Pesticides In-hive Strips) with a specific pesticide absorbent which is hung between the bee combs.Beebread and pollen collected in pollen traps are being sampled every two weeks to be analysed for pesticide residues and to record foraging conditions. Trapped pollen provides snapshots of the foraging conditions and contaminants on a single day. During the active season, the majority of beebread is consumed within days, so beebread provides recent, random sampling results. The Beehold tube and the APIStrips are present throughout the 2-weeks sampling periods in the beehive, absorbing and accumulating the incoming contaminants. The four matrices i.e. trapped pollen, beebread, Beehold tubes and APIStrips will be analysed for the presence of pesticides. The botanical origin of trapped pollen, beebread and pollen in the Beehold tubes will also be determined with an innovative molecular technique. Data on pollen and pesticide presence will then be combined to obtain information on foraging conditions and pesticide use, together with evaluation of the CORINE database for land use and pesticide legislation to model the exposure risks to honey bees and wild bees. All monitoring steps from sampling through to analysis will be studied and rigorously tested in four countries in Year 1, and the best practices will then be ring-tested in nine countries in Year 2. Information about the course of the project, its results and publications will be available on the INSIGNIA website www.insignia-bee.eu and via social media: on Facebook (https://www.facebook.com/insigniabee.eu/); Instagram insignia_bee); and Twitter (insignia_bee). Although the analyses of pesticide residues and pollen identification will not be completed until December 2019, in my talk I will present preliminary results of the Year 1 sampling.info:eu-repo/semantics/publishedVersio