Acoustic bubble removal method

A method is described for removing bubbles from a liquid bath such as a bath of molten glass to be used for optical elements. Larger bubbles are first removed by applying acoustic energy resonant to a bath dimension to drive the larger bubbles toward a pressure well where the bubbles can coalesce and then be more easily removed. Thereafter, submillimeter bubbles are removed by applying acoustic energy of frequencies resonant to the small bubbles to oscillate them and thereby stir liquid immediately about the bubbles to facilitate their breakup and absorption into the liquid

Cooling of a Micro-mechanical Resonator by the Back-action of Lorentz Force

Using a semi-classical approach, we describe an on-chip cooling protocol for a micro-mechanical resonator by employing a superconducting flux qubit. A Lorentz force, generated by the passive back-action of the resonator's displacement, can cool down the thermal motion of the mechanical resonator by applying an appropriate microwave drive to the qubit. We show that this onchip cooling protocol, with well-controlled cooling power and a tunable response time of passive back-action, can be highly efficient. With feasible experimental parameters, the effective mode temperature of a resonator could be cooled down by several orders of magnitude.Comment: 10 pages, 4 figure

Superfluidity of Λ\Lambda hyperons in neutron stars

We study the $^1S_0$ superfluidity of $\Lambda$ hyperons in neutron star matter and neutron stars. We use the relativistic mean field (RMF) theory to calculate the properties of neutron star matter. In the RMF approach, the meson-hyperon couplings are constrained by reasonable hyperon potentials that include the updated information from recent developments in hypernuclear physics. To examine the $^1S_0$ pairing gap of $\Lambda$ hyperons, we employ several $\Lambda\Lambda$ interactions based on the Nijmegen models and used in double-$\Lambda$ hypernuclei studies. It is found that the maximal pairing gap obtained is a few tenths of a MeV. The magnitude and the density region of the pairing gap are dependent on the $\Lambda\Lambda$ interaction and the treatment of neutron star matter. We calculate neutron star properties and find that whether the $^1S_0$ superfluidity of $\Lambda$ hyperons exists in the core of neutron stars mainly depends on the $\Lambda\Lambda$ interaction used.Comment: 22 pages, 2 Tables, 6 Figur

A Robust Rational Route to in a Simple Asset Pricing Model (revised March 2004)

We investigate asset pricing dynamics in an adaptive evolutionary asset pricing model with fundamentalists, trend followers and a market maker. Agents can choose between a fundamentalist strategy at positive information cost or choose a trend following strategy for free. Price adjustment is proportional to the excess demand in the asset market. Agents asynchronously update their strategy according to realized net profits in the recent past. As agents become more sensitive to differences in strategy performance, the fundamental steady state becomes unstable and multiple steady states may arise. As the traders' sensitivity to differences in fitness increases, a bifurcation route to chaos sets in due to homoclinic bifurcations of stable and unstable manifolds of the fundamental steady state.

Non-fragile H∞ control with randomly occurring gain variations, distributed delays and channel fadings

This study is concerned with the non-fragile H∞ control problem for a class of discrete-time systems subject to randomly occurring gain variations (ROGVs), channel fadings and infinite-distributed delays. A new stochastic phenomenon (ROGVs), which is governed by a sequence of random variables with a certain probabilistic distribution, is put forward to better reflect the reality of the randomly occurring fluctuation of controller gains implemented in networked environments. A modified stochastic Rice fading model is then exploited to account for both channel fadings and random time-delays in a unified representation. The channel coefficients are a set of mutually independent random variables which abide by any (not necessarily Gaussian) probability density function on [0, 1]. Attention is focused on the analysis and design of a non-fragile H∞ outputfeedback controller such that the closed-loop control system is stochastically stable with a prescribed H∞ performance. Through intensive stochastic analysis, sufficient conditions are established for the desired stochastic stability and H∞ disturbance attenuation, and the addressed non-fragile control problem is then recast as a convex optimisation problem solvable via the semidefinite programme method. An example is finally provided to demonstrate the effectiveness of the proposed design method

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity

The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies. Active regulator of SIRT1 (AROS) was the first reported post-transcriptional regulator of SIRT1 activity, enhancing SIRT1-mediated deacetylation and downregulation of the SIRT1 target p53. However, little is known regarding the role of AROS in regulation of SIRT1 during disease. Here, we report the cellular and molecular effects of RNAi-mediated AROS suppression, comparing this with the role of SIRT1 in a panel of human cell lines of both cancerous and non-cancerous origins. Unexpectedly, AROS is found to vary in its modulation of p53 acetylation according to cell context. AROS suppresses p53 acetylation only following the application of cell damaging stress, whereas SIRT1 suppresses p53 under all conditions analysed. This supplements the original characterization of AROS but indicates that SIRT1 activity can persist following suppression of AROS. We also demonstrate that knockdown of AROS induces apoptosis in three cancer cell lines, independent of p53 activation. Importantly, AROS is not required for the viability of three non-cancer cell lines indicating a putative role for AROS in specifically promoting cancer cell survival