Reducing Calorie Intake May Not Help You Lose Body Weight

Background Previously a meta-analysis found that multi-vitamin/mineral supplementation reduced mild psychiatric symptoms. To establish mechanisms, and to pin-point the individuals most likely to benefit, the role of various polymorphisms were examined. Supplementation was found to influence mild-psychiatric symptoms depending on the form of particular genes: genes that are risk factors for psychiatric disease and influence mechanisms by which drugs act. Methods In a double-blind trial young healthy males rated psychiatric symptoms, before and after taking vitamin/mineral supplements for three months, and the response was related to single nucleotide polymorphisms associated with catecholamines and serotonin. Outcomes With rs1800497 (Taq1A; dopamine D2 receptor), those with the CT allele benefitted from a vitamin/mineral supplement. Similarly with rs1800955 (DRD4 – dopamine D4 receptor), the mood of those with the CC allele benefitted selectively. With rs6296 (HTR1B) only those with the GC alleles responded, and with rs6311 (HTR2A) supplementation produced a beneficial response in those with the GG allele. With rs1050565 (5HTT gene - Human Serotonin Transporter gene) supplementation increased the mental health of those with the AA allele. Interpretation In a situation where a substantial proportion of patients do not benefit from drug therapy, and there is an element of trial and error when prescribing, it was proposed that future work should consider distinguishing patients depending on various polymorphisms and micro-nutrient status. In those with particular alleles, we should consider if drug administration and vitamin / mineral status interact synergistically to influence the therapeutic outcom

Dietary factors impact on the association between CTSS variants and obesity related traits.

Cathepsin S, a protein coded by the CTSS gene, is implicated in adipose tissue biology--this protein enhances adipose tissue development. Our hypothesis is that common variants in CTSS play a role in body weight regulation and in the development of obesity and that these effects are influenced by dietary factors--increased by high protein, glycemic index and energy diets

QSOs Associated with Messier 82

The starburst / AGN galaxy M82 was studied by Dahlem, Weaver and Heckman using X-ray data from ROSAT and ASCA, as part of their X-ray survey of edge-on starburst galaxies. They found seventeen unresolved hard-X-ray sources around M82, in addition to its strong nuclear source, and other X-rays within the main body of M82. We have measured optical point sources at these positions, and have obtained redshifts of six candidates at the Keck I 10-m telescope, using the low-resolution imaging spectrograph (LRIS). All six are highly compact optical and X-ray objects with redshifts ranging from 0.111 to 1.086. They all show emission lines. The three with the highest redshifts are clearly QSOs. The others with lower redshifts may either be QSOs or compact emission-line galaxies. In addition to these six there are nine QSOs lying very close to M82 which were discovered many years ago. There is no difference between optical spectra of these latter QSOs, only two of which are known to be X-ray sources, and the X-ray emitting QSOs. The redshifts of all fifteen range between 0.111 and 2.05. The large number of QSOs and their apparent association with ejected matter from M82 suggest that they are physically associated with the galaxy, and have large intrinsic redshift components. If this is correct, the absolute magnitudes lie in the range -8 < M_v < -10. Also we speculate that the luminous variable X-ray source which has been detected by Chandra in the main body of M82 some 9 arcseconds from the center is another QSO in the process of ejection from the nucleus, and propose some observational tests of this hypothesis.Comment: 16 pages aastex, 3 eps figures, accepted for publication on Ap

Widespread tephra dispersal and ignimbrite emplacement from a subglacial volcano (Torfajökull, Iceland)

The tephra dispersal mechanisms of rhyolitic glaciovolcanic eruptions are little known, but can be investigated through the correlation of eruptive products across multiple depositional settings. Using geochemistry and geochronology, we correlate a regionally important Pleistocene tephra horizon—the rhyolitic component of North Atlantic Ash Zone II (II-RHY-1)—and the Thórsmörk Ignimbrite with rhyolitic tuyas at Torfajökull volcano, Iceland. The eruption breached an ice mass >400 m thick, leading to the widespread dispersal of II-RHY-1 across the North Atlantic and the Greenland ice sheet. Locally, pyroclastic density currents traveled across the ice surface, depositing the variably welded Thórsmörk Ignimbrite beyond the ice margin and ~30 km from source. The widely dispersed products of this eruption represent a valuable isochronous tie line between terrestrial, marine, and ice-core paleoenvironmental records. Using the tephra horizon, estimates of ice thickness and extent derived from the eruption deposits can be directly linked to the regional climate archive, which records the eruption at the onset of Greenland Stadial 15.2

Planar projections of graphs

We introduce and study a new graph representation where vertices are embedded in three or more dimensions, and in which the edges are drawn on the projections onto the axis-parallel planes. We show that the complete graph on $n$ vertices has a representation in $\lceil \sqrt{n/2}+1 \rceil$ planes. In 3 dimensions, we show that there exist graphs with $6n-15$ edges that can be projected onto two orthogonal planes, and that this is best possible. Finally, we obtain bounds in terms of parameters such as geometric thickness and linear arboricity. Using such a bound, we show that every graph of maximum degree 5 has a plane-projectable representation in 3 dimensions.Comment: Accepted at CALDAM 202

Guidelines for the use of chest radiographs in community-acquired pneumonia in children and adolescents

National guidance from the United Kingdom and the United States on community-acquired pneumonia in children states that chest radiographs are not recommended routinely in uncomplicated cases. The main reason in the ambulatory setting is that there is no evidence of a substantial impact on clinical outcomes. However clinical practice and adherence to guidance is multifactorial and includes the clinical context (developed vs. developing world), the confidence of the attending physician, the changing incidence of complications (according to the success of immunisation programs), the availability of alternative imaging (and its relationship to perceived risks of radiation) and the reliability of the interpretation of imaging. In practice, chest radiographs are performed frequently for suspected pneumonia in children. Time pressures facing clinicians at the front line, difficulties in distinguishing which children require admission, restricted bed numbers for admissions, imaging-resource limitations, perceptions regarding risk from procedures, novel imaging modalities and the probability of other causes for the child's presentation all need to be factored into a guideline. Other drivers that often weigh in, depending on the setting, include cost-effectiveness and the fear of litigation. Not all guidelines designed for the developed world can therefore be applied to the developing world, and practice guidelines require regular review in the context of new information. In addition, radiologists must improve radiographic diagnosis of pneumonia, reach consensus on the interpretive terminology that clarifies their confidence regarding the presence of pneumonia and act to replace one imaging technique with another whenever there is proof of improved accuracy or reliability.</p

Soil-transmitted helminth infections and nutritional indices among Filipino schoolchildren

BACKGROUND: Soil-transmitted helminth (STH) infections are still prevalent among schoolchildren in the Philippines. We evaluated the risk factors associated with STH and the relationship between STH and nutritional indices among schoolchildren aged 9-10 years in Laguna province, the Philippines. METHODS: We used the baseline data from 40 schools enrolled in a randomised controlled trial of the Magic Glasses Philippines health education package. Data on demographic and socio-economic variables, and STH related knowledge, attitudes and practices, were obtained through a questionnaire. Stool samples were collected and assessed for STH egg presence using the Kato-Katz technique. Haemoglobin levels and height and weight of study participants were also determined. The generalized estimating equations approach was used to construct logistic regression models to assess STH-associated risk factors, and the association between any STH infection and anaemia, child stunting, wasting and being underweight. The trial is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12616000508471). FINDINGS: Among 1,689 schoolchildren, the prevalence of any STH was 23%. The prevalence of anaemia, stunting, being underweight and wasting was 13%, 20.2%, 19% and 9.5%, respectively. Age, socio-economic status, rural/urban classification of schools and knowledge of STH were significant risk factors for acquiring a STH infection. Moreover, infections with any STH were significantly associated with stunting (P = <0.001) and being underweight (P = <0.003), but not wasting (P = 0.375) or anaemia (P = 0.462) after controlling for confounding covariates. CONCLUSION: The study findings emphasise the need for sustainable deworming in tandem with other measures such as the provision of health education, improvements in sanitation and hygiene, and nutritional programs in order to control STH infections and improve morbidity outcomes in schoolchildren. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry (ACTRN12616000508471)

The Surroundings of Disturbed, Active Galaxies

The brightest apparent magnitude examples of ultra luminous infrared galaxies (ULIRG's) are studied here in X-ray, optical, infrared and radio wavelengths. It is is found that they have associated material reaching out to apparent diameters of the order of a degree on the sky. Gas, dust, X-ray material and quasars appear to be ejected from the active nuclei with all objects nearer than their redshift distances.Comment: 14 pages, Figs. 1-28 jpg and gif file