BLITZEN: A highly integrated massively parallel machine

The architecture and VLSI design of a new massively parallel processing array chip are described. The BLITZEN processing element array chip, which contains 1.1 million transistors, serves as the basis for a highly integrated, miniaturized, high-performance, massively parallel machine that is currently under development. Each processing element has 1K bits of static RAM and performs bit-serial processing with functional elements for arithmetic, logic, and shifting

Spontaneous Iliopsoas Hematoma following Microvascular Free Tissue Transfer.

Spontaneous hematoma within the iliopsoas muscle (SIH) is a rare complication most commonly seen in coagulopathic patients. Often, patients undergoing microvascular free tissue transfer are anticoagulated for anastomotic patency. Here we describe two cases of postoperative SIH following contralateral anterolateral thigh (ALT) free tissue transfer for reconstruction of oncologic head and neck defects. Both patients described hip pain after mobilization and had a corresponding acute blood loss anemia. Diagnosis of SIH was confirmed by CT and both patients were managed conservatively. Given that anticoagulation is a common practice following head and neck free tissue transfer, surgeons should be aware of this potential complication

The Remarkable Mid-Infrared Jet of Massive Young Stellar Object G35.20-0.74

The young massive stellar object G35.20-0.74 was observed in the mid-infrared using T-ReCS on Gemini South. Previous observations have shown that the near infrared emission has a fan-like morphology that is consistent with emission from the northern lobe of a bipolar radio jet known to be associated with this source. Mid-infrared observations presented in this paper show a monopolar jet-like morphology as well, and it is argued that the mid-infrared emission observed is dominated by thermal continuum emission from dust. The mid-infrared emission nearest the central stellar source is believed to be directly heated dust on the walls of the outflow cavity. The hydroxyl, water, and methanol masers associated with G35.20-0.74 are spatially located along these mid-infrared cavity walls. Narrow jet or outflow cavities such as this may also be the locations of the linear distribution of methanol masers that are found associated with massive young stellar objects. The fact that G35.20-0.74 has mid-infrared emission that is dominated by the outflow, rather than disk emission, is a caution to those that consider mid-infrared emission from young stellar objects as only coming from circumstellar disks.Comment: Accepted for publication in ApJ Letters; 4 pages; 2 figures; a version with full resolution images is available here: http://www.ctio.noao.edu/~debuizer

Nivolumab-induced fulminant diabetic ketoacidosis followed by thyroiditis

Five days following the 3rd cycle of nivolumab, a monoclonal antibody, which acts as immune checkpoint inhibitor against the programmed cell death protein-1, for metastatic lung adenocarcinoma, a 56-year-old woman presented at the hospital critically ill. On admission, she had severe diabetic ketoacidosis (DKA), as evidenced by venous glucose of 47 mmol/L, blood ketones of 7.5 mmol/L, pH of 6.95 and bicarbonate of 6.6 mmol/L. She has had no personal or family history of diabetes mellitus (DM), while random venous glucose, measured 1 week prior to hospitalisation, was 6.1 mmol/L. On admission, her HbA1c was 8.2% and anti-GAD antibodies were 12 kIU/L (0–5 kU/L), while islet cell antibodies and serum C-peptide were undetectable. Nivolumab was recommenced without the development of other immune-mediated phenomena until 6 months later, when she developed hypothyroidism with TSH 18 U/L and low free T4. She remains insulin dependent and has required levothyroxine replacement, while she has maintained good radiological and clinical response to immunotherapy. This case is notable for the rapidity of onset and profound nature of DKA at presentation, which occurred two months following commencement of immunotherapy. Despite the association of nivolumab with immune-mediated endocrinopathies, only a very small number of patients developing type 1 DM has been reported to date. Patients should be closely monitored for hyperglycaemia and thyroid dysfunction prior to and periodically during immunotherapy

Propagating waves in the steel, moment-frame factor building recorded during earthquakes

Wave-propagation effects can be useful in determining the system identification of buildings such as the densely instrumented University of California, Los Angeles, Factor building. Waveform data from the 72-channel array in the 17-story moment-resisting steel frame Factor building are used in comparison with finiteelement calculations for predictive behavior. The high dynamic range of the 24-bit digitizers allows both strong motions and ambient vibrations to be recorded with reasonable signal-to-noise ratios. A three-dimensional model of the Factor building has been developed based on structural drawings. Observed displacements for 20 small and moderate, local and regional earthquakes were used to compute the impulse response functions of the building by deconvolving the subbasement records as representative input motions at its base. The impulse response functions were then stacked to bring out wave-propagation effects more clearly. The stacked data are used as input into theoretical dynamic analysis simulations of the building’s response

Possible tsunami along the northwestern coast of the United States inferred from Indian traditions

Subduction of the Juan de Fuca and Gorda plates beneath western North America presents a paradox; despite the fact that there is good evidence of 3 to 4 cm/yr of ongoing convergence, there is a remarkable paucity of either historic or instrumentally recorded shallow subduction earthquakes. Steady aseismic slip along the entire Cascadia subduction zone provides one explanation for this seismic quiescence. However, the Cascadia subduction zone shares many features, including temporal quiescence, with other subduction zones that have experienced very large shallow subduction earthquakes (Heaton and Kanamori, 1984). Yet, there is no direct geologic or historical evidence presently available to confirm that great shallow subduction earthquakes have occurred along the coast of Washington, Oregon, and northern California. However, there are reports describing Indian legends of great sea-level disturbances that may be related to large nearby earthquakes. In this letter, we briefly review the history of exploration and settlement of this region by nonnative people and then discuss legends from Indians in northern Washington and northern California

Prediction of Wave Propagation in Buildings Using Data from a Single Seismometer

Crowd‐sourced seismic networks in buildings collect important scientific data, in addition to allowing a diverse audience to visualize the vibrations of buildings. Visualization of a building’s deformation requires spatiotemporal interpolation of motions from seismometers that are located wherever the crowd places them. In many cases, a crowd‐sourced building network may actually be just a single seismometer. A method to rapidly estimate the total displacement response of a building based on limited observational data, in some cases from only a single seismometer, is presented. In general, the earliest part of the response is simulated by assuming a vertically propagating shear wave. Later motions are simulated using mode shapes derived from a beam model (a shear beam, or more generally a Timoshenko beam), the parameters of which are determined from the ratios of the modal frequencies and the building’s exterior dimensions. The method is verified by (1) comparing predicted and actual records from a 54‐story building in downtown Los Angeles, California, and (2) comparing finite‐element simulations of the 17‐story University of California, Los Angeles (UCLA) Factor building. The response of each of these buildings can be simulated with a simple shear beam. The importance of including the traveling wave part of the solution depends on the characteristics of the base ground shaking; the traveling wave becomes more apparent as the excitation becomes more impulsive. The method can be straightforwardly applied to multiple instrumented buildings, resulting in a tool to visualize linear elastic motions of those buildings

Frequency of neurolopsychological deficits after traumatic brain injury

El traumatismo craneoencefálico (TCE) puede conllevar impactantes cambios en la vida cotidiana, que incluyen alteraciones a nivel social, profesional, comunicativo y cognitivo (dificultades atencionales, mnemónicas y ejecutivas). Este estudio tuvo por objeto caracterizar la ocurrencia de déficits neuropsicológicos post-TCE y constatar el impacto ocasionado por el nivel de severidad del trauma en el desempeño cognitivo de los pacientes. Participaron 96 adultos en la muestra total, que fue dividida en dos grupos para evaluar el nivel de severidad del trauma: TCE leve (n=39) y TCE grave (n=77). La gravedad de la lesión se clasificó por medio de la Escala de Coma de Glasgow, por la duración de la pérdida de consciencia, o por la amnesia post-traumática. No había diferencias entre la edad y la escolaridad de los participantes. Para la comparación entre los grupos en cuanto a la distribución de ocurrencia de déficits neuropsicológicos, se utilizó el Chi-cuadrado. Se utilizó una batería de evaluación neuropsicológica flexible conformada por tareas verbales y visoespaciales de habilidades lingüísticas, mnemónicas y ejecutivas. Los grupos no se diferenciaron en cuanto a las variables sociodemográficas. Los pacientes con TCE leve tuvieron mejores puntajes comparados con los de TCE grave (número de errores y categorías completadas del Test de clasificación de tarjetas de Wisconsin- [WCST, por sus siglas en inglés]; errores en la parte B del Test de Hayling; y en la interferencia retro y proactiva del Test de aprendizaje auditivo verbal de Rey [RAVLT, por sus siglas en inglés]. El nivel de severidad del trauma parece mostrar diferencias en los individuos en cuanto al desempeño en memoria episódica de información nueva y en el control de interferencia entre los recuerdos; lo mismo se aplica a las funciones de flexibilidad e inhibición. Estos resultados sugieren que es necesaria una mayor inversión en acciones de políticas públicas, priorizando intervenciones neurocognitivas reeducativas y métodos de prevención de accidentes relacionados con lesiones traumáticas que tengan alta incidencia de secuelas.El traumatismo craneoencefálico (TCE) puede conllevar impactantes cambios en la vida cotidiana, que incluyen alteraciones a nivel social, profesional, comunicativo y cognitivo (dificultades atencionales, mnemónicas y ejecutivas). Este estudio tuvo por objeto caracterizar la ocurrencia de déficits neuropsicológicos post-TCE y constatar el impacto ocasionado por el nivel de severidad del trauma en el desempeño cognitivo de los pacientes. Participaron 96 adultos en la muestra total, que fue dividida en dos grupos para evaluar el nivel de severidad del trauma: TCE leve (n=39) y TCE grave (n=77). La gravedad de la lesión se clasificó por medio de la Escala de Coma de Glasgow, por la duración de la pérdida de consciencia, o por la amnesia post-traumática. No había diferencias entre la edad y la escolaridad de los participantes. Para la comparación entre los grupos en cuanto a la distribución de ocurrencia de déficits neuropsicológicos, se utilizó el Chi-cuadrado. Se utilizó una batería de evaluación neuropsicológica flexible conformada por tareas verbales y visoespaciales de habilidades lingüísticas, mnemónicas y ejecutivas. Los grupos no se diferenciaron en cuanto a las variables sociodemográficas. Los pacientes con TCE leve tuvieron mejores puntajes comparados con los de TCE grave (número de errores y categorías completadas del Test de clasificación de tarjetas de Wisconsin- [WCST, por sus siglas en inglés]; errores en la parte B del Test de Hayling; y en la interferencia retro y proactiva del Test de aprendizaje auditivo verbal de Rey [RAVLT, por sus siglas en inglés]. El nivel de severidad del trauma parece mostrar diferencias en los individuos en cuanto al desempeño en memoria episódica de información nueva y en el control de interferencia entre los recuerdos; lo mismo se aplica a las funciones de flexibilidad e inhibición. Estos resultados sugieren que es necesaria una mayor inversión en acciones de políticas públicas, priorizando intervenciones neurocognitivas reeducativas y métodos de prevención de accidentes relacionados con lesiones traumáticas que tengan alta incidencia de secuelas.Traumatic brain injury (TBI) can lead to significant changes in daily life, as well as in social, labor, communicative, and cognitive domains (attention, memory and executive functions). This study aimed to characterize the occurrence of post-TBI neuropsychological deficits as well as to determine whether there is an impact related to the level of severity of the trauma on the patient's performance. Ninety-six adults participated in the study, who were divided in two groups to assess the trauma's level of severity: mild TBI (n=39) and severe TBI (n=57). This severity was classified by the Glasgow Coma Scale, by the duration of consciousness loss, or by post-traumatic amnesia. There were no differences between the groups regarding variables of age and years of schooling. A Chi- square test was used to do a comparison between the two groups in terms of occurrence of neuropsychological deficits. Verbal, visuospatial, mnemonic, linguistic and executive tests composed a flexible neuropsychological battery. Patients with mild TBI had better scores compared to those with severe TBI (number of errors and in completed categories of the Modified Wisconsin Card Sorting Test (MWCST); errors in Part B of The Hayling Test; and proactive and retroactive interference in the Rey Auditory Verbal Learning Test (RAVLT). The severity of the trauma seems to differentiate individual's performance on episodic memory of new information and in the control of interference between memories; the same is applied to flexibility and inhibition functions. These results suggest the need for more investments in public health policy actions, prioritizing neurocognitive remedial intervention and prevention methods for such condition with high incidence of sequelae

Detecting failure events in buildings: a numerical and experimental analysis

A numerical method is used to investigate an approach for detecting the brittle fracture of welds associated with beam -column connections in instrumented buildings in real time through the use of time-reversed Green’s functions and wave propagation reciprocity. The approach makes use of a prerecorded catalog of Green’s functions for an instrumented building to detect failure events in the building during a later seismic event by screening continuous data for the presence of waveform similarities to one of the prerecorded events. This study addresses whether a set of Green’s functions in response to an impulsive force load can be used to approximate the response of the structure to a localized failure event such as a brittle weld fracture. Specifically, we investigate whether prerecorded Green’s functions can be used to determine the absolute time and location of a localized failure event in a building. We also seek to differentiate between sources such as a weld fracture that are structurally damaging and sources such as falling or colliding furniture and other non-structural elements that do not contribute to structural failure. This is explored numerically by comparing the dynamic response of a finite-element cantilevered beam model structure to a variety of loading mechanisms. A finite-element method is employed to determine the behavior of the resulting elastic waves and to obtain a general understanding of the structural response