Quantitative characterisation of contourite deposits using medical CT

Five sediment cores, retrieved from four different depositional contouritic morphological settings (a sheeted drift, a confined mounded drift, a mounded elongated drift and a plastered drift) from the Northern Gulf of Cadiz and the Alboran Sea have been analysed using medical X-ray computed tomography (medical CT). A quantitative approach has been used, resulting in a workflow that delineates several radio-density ranges based on the Hounsfield Unit (HU) histogram of each core and tracks these ranges throughout the cores. In order to derive the geological significance, the radio-density ranges of all cores have been compared to non-destructive, continuous chemical and physical proxies as well as grain size measurements. The highest correlations occurred between high HU and proxies indicating elevated bottom currents, such as Zr/Al and sortable silt. Additionally, a continuous increase in average HU and inferred bottom current velocities, needed for the creation of the specific contourite setting, could be observed throughout the five cores. Despite imperfections and the requirement of additional research, promising results have been obtained which could improve the detection of diagnostic criteria for contourites. Moreover, the CT data can give more conclusive evidence on the nature of the (contourite) sedimentary sequence boundaries

The porin and the permeating antibiotic: A selective diffusion barrier in gram-negative bacteria

Gram-negative bacteria are responsible for a large proportion of antibiotic resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm. The outer membrane contains various protein channels, called porins, which are involved in the influx of various compounds, including several classes of antibiotics. Bacterial adaptation to reduce influx through porins is an increasing problem worldwide that contributes, together with efflux systems, to the emergence and dissemination of antibiotic resistance. An exciting challenge is to decipher the genetic and molecular basis of membrane impermeability as a bacterial resistance mechanism. This Review outlines the bacterial response towards antibiotic stress on altered membrane permeability and discusses recent advances in molecular approaches that are improving our knowledge of the physico-chemical parameters that govern the translocation of antibiotics through porin channel

Spherically symmetric dissipative anisotropic fluids: A general study

The full set of equations governing the evolution of self--gravitating spherically symmetric dissipative fluids with anisotropic stresses is deployed and used to carry out a general study on the behaviour of such systems, in the context of general relativity. Emphasis is given to the link between the Weyl tensor, the shear tensor, the anisotropy of the pressure and the density inhomogeneity. In particular we provide the general, necessary and sufficient, condition for the vanishing of the spatial gradients of energy density, which in turn suggests a possible definition of a gravitational arrow of time. Some solutions are also exhibited to illustrate the discussion.Comment: 28 pages Latex. To appear in Phys.Rev.

Precision on leptonic mixing parameters at future neutrino oscillation experiments

We perform a comparison of the different future neutrino oscillation experiments based on the achievable precision in the determination of the fundamental parameters theta_{13} and the CP phase, delta, assuming that theta_{13} is in the range indicated by the recent Daya Bay measurement. We study the non-trivial dependence of the error on delta on its true value. When matter effects are small, the largest error is found at the points where CP violation is maximal, and the smallest at the CP conserving points. The situation is different when matter effects are sizable. As a result of this effect, the comparison of the physics reach of different experiments on the basis of the CP discovery potential, as usually done, can be misleading. We have compared various proposed super-beam, beta-beam and neutrino factory setups on the basis of the relative precision of theta_{13} and the error on delta. Neutrino factories, both high-energy or low-energy, outperform alternative beam technologies. An ultimate precision on theta_{13} below 3% and an error on delta of < 7^{\circ} at 1 sigma (1 d.o.f.) can be obtained at a neutrino factory.Comment: Minor changes, matches version accepted in JHEP. 30 pages, 9 figure

Gaia FGK benchmark stars: abundances of α and iron-peak elements

Context. In the current era of large spectroscopic surveys of the Milky Way, reference stars for calibrating astrophysical parameters and chemical abundances are of paramount importance. Aims. We determine elemental abundances of Mg, Si, Ca, Sc, Ti, V, Cr, Mn, Co, and Ni for our predefined set of Gaia FGK benchmark stars. Methods. By analysing high-resolution spectra with a high signal-to-noise ratio taken from several archive datasets, we combined results of eight different methods to determine abundances on a line-by-line basis. We performed a detailed homogeneous analysis of the systematic uncertainties, such as differential versus absolute abundance analysis. We also assessed errors that are due to non-local thermal equilibrium and the stellar parameters in our final abundances. Results. Our results are provided by listing final abundances and the different sources of uncertainties, as well as line-by-line and method-by-method abundances. Conclusions. The atmospheric parameters of the Gaia FGK benchmark stars are already being widely used for calibration of several pipelines that are applied to different surveys. With the added reference abundances of ten elements, this set is very suitable for calibrating the chemical abundances obtained by these pipelines

High intensity neutrino oscillation facilities in Europe

The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Fréjus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of μ+ and μ− beams in a storage ring. The far detector in this case is a 100 kt magnetized iron neutrino detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular He6 and Ne18, also stored in a ring. The far detector is also the MEMPHYS detector in the Fréjus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the physics reach of each facility, in particular for the measurement of CP violation in the lepton sector, and estimated the cost of construction. These have demonstrated that the best facility to build is the Neutrino Factory. However, if a powerful proton driver is constructed for another purpose or if the MEMPHYS detector is built for astroparticle physics, the Super Beam also becomes very attractive

Chemical Abundances of M-Dwarfs from the Apogee Survey. I. The Exoplanet Hosting Stars Kepler-138 and Kepler-186

We report the first detailed chemical abundance analysis of the exoplanet-hosting M-dwarf stars Kepler-138 and Kepler-186 from the analysis of high-resolution (R ∼ 22,500) H-band spectra from the SDSS-IV–APOGEE survey. Chemical abundances of 13 elements—C, O, Na, Mg, Al, Si, K, Ca, Ti, V, Cr, Mn, and Fe—are extracted from the APOGEE spectra of these early M-dwarfs via spectrum syntheses computed with an improved line list that takes into account H2O and FeH lines. This paper demonstrates that APOGEE spectra can be analyzed to determine detailed chemical compositions of M-dwarfs. Both exoplanet-hosting M-dwarfs display modest subsolar metallicities: [Fe/H]Kepler-138 = −0.09 ± 0.09 dex and [Fe/H]Kepler-186 = −0.08 ± 0.10 dex. The measured metallicities resulting from this high-resolution analysis are found to be higher by ∼0.1–0.2 dex than previous estimates from lower-resolution spectra. The C/O ratios obtained for the two planet-hosting stars are near-solar, with values of 0.55 ± 0.10 for Kepler-138 and 0.52 ± 0.12 for Kepler-186. Kepler-186 exhibits a marginally enhanced [Si/Fe] ratio

Revisiting cosmological bounds on sterile neutrinos

We employ state-of-the art cosmological observables including supernova surveys and BAO information to provide constraints on the mass and mixing angle of a non-resonantly produced sterile neutrino species, showing that cosmology can effectively rule out sterile neutrinos which decay between BBN and the present day. The decoupling of an additional heavy neutrino species can modify the time dependence of the Universe's expansion between BBN and recombination and, in extreme cases, lead to an additional matter-dominated period; while this could naively lead to a younger Universe with a larger Hubble parameter, it could later be compensated by the extra radiation expected in the form of neutrinos from sterile decay. However, recombination-era observables including the Cosmic Microwave Background (CMB), the shift parameter R-CMB and the sound horizon r(s) from Baryon Acoustic Oscillations (BAO) severely constrain this scenario. We self-consistently include the full time-evolution of the coupled sterile neutrino and standard model sectors in an MCMC, showing that if decay occurs after BBN, the sterile neutrino is essentially bounded by the constraint sin(2) theta less than or similar to 0.026(m(s)/eV)(-2)

The role of late Quaternary tectonic activity and sea-level changes on sedimentary processes interaction in the Gulf of Cadiz upper and middle continental slope (SW Iberia)

A morphological and seismic-stratigraphic analysis of the Gulf of Cadiz area near the Strait of Gibraltar is presented in this work, focused on the sedimentary evolution of the upper and proximal middle-continental slope since the Mid-Pleistocene. Based on the analysis of seismic reflection profiles and swath bathymetry data, this work analyses the close influence of the activity of buried and outcropping diapiric ridges and late Quaternary sea-level changes on the evolution of contouritic features related to the Mediterranean Outflow Water (MOW) and Eastern North Atlantic Central Water (ENACW), gravitational features and fluid-escape structures. The stratigraphic architecture reveals that, under active diapiric deformation, the upper slope plastered drift grew during low sea-level stages, when sediment supply was high and the ENACW swept the upper slope, contrasting with the present-day highstand situation dominated by northwest-trending MOW flow. The south-estward ENACW flow forced asymmetry and lateral migration of gullies incised in the plastered drift. Two evolutionary stages have been established: 1) After the Mid Pleistocene, activity of diapirs with a NE trend determined the location of the deepest depressions which were infilled by plastered contouritic drifts; 2) Between Late Quaternary and present, a drastic change of buried diapirs growth pattern and orientation to a NW trend enhanced slope-derived gravitational processes affecting the bottom current dynamics. Adjustments to tectonic changes led to a phase of plastered drift growth on the upper slope during which depocenters varied their distribution and orientation. In a long-term the structural control on sedimentation shows a northwestward displacement of deformation, resulting in an overall extension of the contourite depositional system to the NW. In a short-term, sea-level changes favored drift deposition, gullies incision and the strengthening of water masses. This work evidences the importance of tectonic deformation in sedimentation at recent time scales, and the twodirectional interplay between recent tectonic activity and bottom current dynamics.Versión del edito

In silico and In vitro analysis of MAP3773c protein from Mycobacterium avium subsp. Paratuberculosis

Paratuberculosis is a disease caused by Mycobacterium avium subsp. paratuberculosis (MAP). It is of great interest to better understand the proteins involved in the pathogenicity of this organism in order to be able to identify potential therapeutic targets and design new vaccines. The protein of interest–MAP3773c–was investigated, and molecular modeling in silico, docking, cloning, expression, purification, and partial characterization of the recombinant protein were achieved. In the in silico study, it was shown that MAP3773c of MAP has 34% sequence similarity with Mycobacterium tuberculosis (MTB) FurB, which is a zinc uptake regulator (Zur) protein. The docking data showed that MAP3773c exhibits two metal-binding sites. The presence of structural Zn2+ in the purified protein was confirmed by SDS-PAGE PAR staining. The purification showed one band that corresponded to a monomer, which was confirmed by liquid chromatography–mass spectrometry (LC-MS). The presence of a monomer was verified by analyzing the native protein structure through BN-SDS-PAGE (Native Blue (BN) Two-Dimensional Electrophoresis) and BN–Western blotting. The MAP3773c protein contains structural zinc. In conclusion, our results show that MAP3773c displays the features of a Fur-type protein with two metal-binding sites, one of them coordinating structural Zn2+