Advanced general aviation comparative engine/airframe integration study

The NASA Advanced Aviation Comparative Engine/Airframe Integration Study was initiated to help determine which of four promising concepts for new general aviation engines for the 1990's should be considered for further research funding. The engine concepts included rotary, diesel, spark ignition, and turboprop powerplants; a conventional state-of-the-art piston engine was used as a baseline for the comparison. Computer simulations of the performance of single and twin engine pressurized aircraft designs were used to determine how the various characteristics of each engine interacted in the design process. Comparisons were made of how each engine performed relative to the others when integrated into an airframe and required to fly a transportation mission

Experimental investigations of the effects of cutting angle on chattering of a flexible manipulator

When a machine tool is mounted at the tip of a robotic manipulator, the manipulator becomes more flexible (the natural frequencies are lowered). Moreover, for a given flexible manipulator, its compliance will be different depending on feedback gains, configurations, and direction of interest. Here, the compliance of a manipulator is derived analytically, and its magnitude is represented as a compliance ellipsoid. Then, using a two-link flexible manipulator with an abrasive cut off saw, the experimental investigation shows that the chattering varies with the saw cutting angle due to different compliance. The main work is devoted to finding a desirable cutting angle which reduces the chattering

“From Margin to Center”: Processes and Relationships to Participation One Woman’s Ethnographic Journey Mirrored through Community Research

In the closing two years of my doctoral degree that spanned ten years of my life, I was asked by a mentor to write a personal essay on my academic experiences at the university. That essay follows and is printed here not without the accompanying editing that marshaled its own questioning, self-reflection and analysis that comes with distance, wisdom, and the editor of a juried journal. I was concerned to give a revisionist accounting now, another five or six years after the writing of the essay, to explain what my perspective was then as a disaffected African- American ABD (all but dissertation), given my changed thinking now, of what matters and what does not; and how my responses would have changed, lessened, or wizened over time. After all, my heightened sensitivity as an emotionally vulnerable and young so-called minority Black female, coming from a politically-charged HBCU (historically-Black college or university) to enter a predominantly white and politically conservative environment brings with it a whole dimension of challenges, the least of which is how to fit in, how not to be invisible, how to be successful and how to gain access to be successful in the midst of myriad real and perceived walls and obstacles

Neutral atomic carbon in the globules of the Helix

We report detection of the 609u line of neutral atomic carbon in globules of the Helix nebula. The measurements were made towards the position of peak CO emission. At the same position, we obtained high-quality CO(2-1) and 13CO(2-1) spectra and a 135" x 135" map in CO(2-1). The velocity distribution of CI shows six narrow (1 -> 2 km/sec) components which are associated with individual globules traced in CO. The CI column densities are 0.5 -> 1.2 x 10^16/cm^2. CI is found to be a factor of ~6 more abundant than CO. Our estimate for the mass of the neutral envelope is an order of magnitude larger than previous estimates. The large abundance of CI in the Helix can be understood as a result of the gradual photoionisation of the molecular envelope by the central star's radiation field.Comment: 5 pages, Latex, AAS macros, 3 EPS figures, to appear in Astrophysical Journal Letter

The economic and innovation contribution of universities: a regional perspective

Universities and other higher education institutions (HEIs) have come to be regarded as key sources of knowledge utilisable in the pursuit of economic growth. Although there have been numerous studies assessing the economic and innovation impact of HEIs, there has been little systematic analysis of differences in the relative contribution of HEIs across regions. This paper provides an exploration of some of these differences in the context of the UK’s regions. Significant differences are found in the wealth generated by universities according to regional location and type of institution. Universities in more competitive regions are generally more productive than those located in less competitive regions. Also, traditional universities are generally more productive than their newer counterparts, with university productivity positively related to knowledge commercialisation capabilities. Weaker regions tend to be more dependent on their universities for income and innovation, but often these universities under-perform in comparison to counterpart institutions in more competitive regions. It is argued that uncompetitive regions lack the additional knowledge infrastructure, besides universities, that are more commonly a feature of more competitive regions

Solid state television camera system Patent

Solid state television camera system consisting of monolithic semiconductor mosaic sensor and molecular digital readout system

Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase.

Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and reduction in toxicity. Indeed, conjugation of tris-GalNAc to siRNAs and ASOs has shown clinical efficacy in targeting diseases driven by liver hepatocytes. However, targeting non-hepatic diseases with oligonucleotide therapeutics has remained problematic for several reasons, including targeting specific cell types and endosomal escape. Monoclonal antibody (mAb) targeting of siRNAs and ASOs has the potential to deliver these drugs to a variety of specific cell and tissue types. However, most conjugation strategies rely on random chemical conjugation through lysine or cysteine residues resulting in conjugate heterogeneity and a distribution of Drug:Antibody Ratios (DAR). To produce homogeneous DAR-2 conjugates with two siRNAs per mAb, we developed a novel two-step conjugation procedure involving microbial transglutaminase (MTGase) tagging of the antibody C-terminus with an azide-functionalized linker peptide that can be subsequently conjugated to dibenzylcyclooctyne (DBCO) bearing oligonucleotides through azide-alkyne cycloaddition. Antibody-siRNA (and ASO) conjugates (ARCs) produced using this strategy are soluble, chemically defined targeted oligonucleotide therapeutics that have the potential to greatly increase the number of targetable cell types

A model of large volumetric capacitance in graphene supercapacitors based on ion clustering

Electric double layer supercapacitors are promising devices for high-power energy storage based on the reversible absorption of ions into porous, conducting electrodes. Graphene is a particularly good candidate for the electrode material in supercapacitors due to its high conductivity and large surface area. In this paper we consider supercapacitor electrodes made from a stack of graphene sheets with randomly-inserted "spacer" molecules. We show that the large volumetric capacitances C > 100 F/cm^3 observed experimentally can be understood as a result of collective intercalation of ions into the graphene stack and the accompanying nonlinear screening by graphene electrons that renormalizes the charge of the ion clusters.Comment: 13 pages, 5 figures; additional discussion and supporting calculations adde

Risk Analysis of Organic Cropping Systems in Minnesota

When all strategies received conventional market prices, 4-year cropping sequences had greater net returns than 2-year sequences, and the organic input, 4-year strategy had the highest net return. Adding 50% of the estimated organic premium, the 4-year, organic strategy dominated all low- and high-purchased input strategies.Crop Production/Industries, Risk and Uncertainty,