564 research outputs found
Dynamics of a flexible rotor in magnetic bearings
Discussed is a magnetic bearing which was designed and tested in a flexible rotor both as support bearings and as a vibration controller. The design of the bearing is described and the effect of control circuit bandwidth determined. Both stiffness and damping coefficients were measured and calculated for the bearing with good agreement. The bearings were then placed in a single mass rotor as support bearings and the machine run through two critical speeds. Measurements were made of the vibration response in plain bushings and magnetic bearings. Comparisons were also made of the theoretical calculations with the measured peak unbalance response speeds. Finally, runs were made with the magnetic bearing used as a vibration controller
The interaction of oxygen atoms with solid surfaces at eV energies Annual status report, 1 Jun. 1968 - 31 May 1969
Interaction of oxygen atoms with solid surfaces at eV energie
Will opposites attract? Similarities and differences in students' perceptions of the stereotype profiles of other health and social care professional groups
The extent to which health and social care (HSC) students hold stereotypical views of other HSC professional groups is of great potential importance to team working in health care. This paper explores students' perceptions of different HSC professional groups at the beginning of their university programmes. Findings are presented from an analysis of baseline data collected as part of the New Generation Project longitudinal cohort study which is assessing the impact of interprofessional education over time on a range of variables including stereotyping. Questionnaires were administered to a cohort of over 1200 students from 10 different HSC professional groups entering their first year of university. Stereotypes were measured using a tool adapted from Barnes et al. (2000) designed to elicit stereotype ratings on a range of nine characteristics. The findings confirm that students arrive at university with an established and consistent set of stereotypes about other health and social care professional groups. Stereotypical profiles were compiled for each professional group indicating the distinctive characteristics of the groups as well as the similarities and differences between groups.
Midwives, social workers and nurses were rated most highly on interpersonal skills and on being a team player whilst doctors were rated most highly on academic ability. Doctors, midwives and social workers were perceived as having the strongest leadership role, whilst doctors were also rated most highly on decision making. All professions were rated highly on confidence and professional competence and, with the exception of social workers, on practical skills. A comparison of profiles for each professional group reveals that, for example, pharmacists and doctors were perceived as having very similar characteristics as were social workers, midwives and nurses. However, the profiles of nurses and doctors were perceived to be very different. The implications of these similarities and differences are discussed in terms of their potential impact on interprofessional interactions, role boundaries and team working
An experimental investigation of an axisymmetric jet in a coflowing airstream
The flow development of an axisymmetric jet exhausting into a moving airstream has been studied. The jet has a Reynolds number of 22,600, and the ratio of the jet velocity to the wind tunnel velocity is 5.1 to 1. The flow field of the axisymmetric jet was examined at locations varying from approximately zero to eight diameters downstream of the orifice. Of primary concern at each downstream location was the mapping of the one point statistical properties of the flow, including mean velocity, turbulent intensity, and intermittency. Autocorrelations and power spectral density curves were determined for both the fluctuating velocity field and the concentration signal at various distances from the jet's center line for different downstream locations. A laser Doppler velocimeter, using a phase locked loop processor, was used to make the desired velocity field measurements which were compared with hot wire anemometer and pressure probe data
Neuropsychological functioning and chronic methadone use:a systematic review and meta-analysis
The authors would like to thank the NHS Fife Research and Development Department for supporting this project.Introduction: There is a presumption that neurocognition is commonly impaired in chronicmethadone exposed individuals (CM) when compared with healthy controls (HP).Additionally, it remains unclear if short term (< 1 year) abstinence (AP) is associated with an altered cognitive profile when compared with CM. Method: A random effect model approach was used on data assembled into the Comprehensive Meta-Analysis programme.Cohen’s d effect sizes and a significance levels of p<0.01 were calculated for each domain. Results: Data from a total cohort of 1063 CM, 412 AP and 879 HP participants, from 23 independent studies indicate global impairments in neurocognitive function in CM relative to HP participants. The smaller body of evidence comparing CM to AP participants is inconclusive. Conclusion: Methodological issues such as small sample sizes, heterogeneity and poor quality limited the interpretation of the results and does not address whether the observed impairments reflect co-morbid functioning, methadone-related sedation and/or other factors. Only higher quality longitudinal studies will permit confident interpretation of the results observed in this meta-analysis.PostprintPeer reviewe
Power gain exhibited by motile mechanosensory neurons in Drosophila ears
In insects and vertebrates alike, hearing is assisted by the motility of mechanosensory cells. Much like pushing a swing augments its swing, this cellular motility is thought to actively augment vibrations inside the ear, thus amplifying the ear's mechanical input. Power gain is the hallmark of such active amplification, yet whether and how much energy motile mechanosensory cells contribute within intact auditory systems has remained uncertain. Here, we assess the mechanical energy provided by motile mechanosensory neurons in the antennal hearing organs of Drosophila melanogaster by analyzing the fluctuations of the sound receiver to which these neurons connect. By using dead WT flies and live mutants (tilB(2), btv(5P1), and nompA(2)) with defective neurons as a background, we show that the intact, motile neurons do exhibit power gain. In WT flies, the neurons lift the receiver's mean total energy by 19 zJ, which corresponds to 4.6 times the energy of the receiver's Brownian motion. Larger energy contributions (200 zJ) associate with self-sustained oscillations, suggesting that the neurons adjust their energy expenditure to optimize the receiver's sensitivity to sound. We conclude that motile mechanosensory cells provide active amplification; in Drosophila, mechanical energy contributed by these cells boosts the vibrations that enter the ear
Chemical sensors and biosensors in liquid environment based on microcantilevers with amplified quality factors
Póster presentado al 1st Senspol Workshop: SENSPOL European Thematic Network (EC Environmental and
Climate Programma) Sensing Technologies for Contaminated Sites and Groundwater celebrado en Alcala de Henares (Madrid-España) en 2001.Peer reviewe
Educating the future workforce: building the evidence about interprofessional learning
This paper addresses the theme of interprofessional education for health and social care professionals as it effects on the development of the work force. The drivers for change in the UK, typified by the Bristol Royal Infirmary and Victoria Climbié inquiries and the response to this in the form of Department of Health policy, are discussed. The need for rapid development of the evidence base around this subject is evident form literature reviews of the impact of interprofessional education. Directions for future research and investment in this area are proposed including the need for a stronger theoretical base and for longitudinal studies over extended periods of time in order to examine short, medium and long term outcomes in relation to health care practice
Clinical and molecular characterization of HER2 amplified-pancreatic cancer
<p>Background:
Pancreatic cancer is one of the most lethal and molecularly diverse malignancies. Repurposing of therapeutics that target specific molecular mechanisms in different disease types offers potential for rapid improvements in outcome. Although HER2 amplification occurs in pancreatic cancer, it is inadequately characterized to exploit the potential of anti-HER2 therapies.</p>
<p>Methods:
HER2 amplification was detected and further analyzed using multiple genomic sequencing approaches. Standardized reference laboratory assays defined HER2 amplification in a large cohort of patients (n = 469) with pancreatic ductal adenocarcinoma (PDAC).</p>
<p>Results:
An amplified inversion event (1 MB) was identified at the HER2 locus in a patient with PDAC. Using standardized laboratory assays, we established diagnostic criteria for HER2 amplification in PDAC, and observed a prevalence of 2%. Clinically, HER2- amplified PDAC was characterized by a lack of liver metastases, and a preponderance of lung and brain metastases. Excluding breast and gastric cancer, the incidence of HER2-amplified cancers in the USA is >22,000 per annum.</p>
<p>Conclusions:
HER2 amplification occurs in 2% of PDAC, and has distinct features with implications for clinical practice. The molecular heterogeneity of PDAC implies that even an incidence of 2% represents an attractive target for anti-HER2 therapies, as options for PDAC are limited. Recruiting patients based on HER2 amplification, rather than organ of origin, could make trials of anti-HER2 therapies feasible in less common cancer types.</p>
United States contributions to the Second International Indian Ocean Expedition (US IIOE-2)
From the Preface: The purpose of this document is to motivate and coordinate U.S. participation in the Second
International Indian Ocean Expedition (IIOE-2) by outlining a core set of research priorities that
will accelerate our understanding of geologic, oceanic, and atmospheric processes and their
interactions in the Indian Ocean. These research priorities have been developed by the U.S.
IIOE-2 Steering Committee based on the outcomes of an interdisciplinary Indian Ocean science
workshop held at the Scripps Institution of Oceanography on September 11-13, 2017. The
workshop was attended by 70 scientists with expertise spanning climate, atmospheric sciences,
and multiple sub-disciplines of oceanography. Workshop participants were largely drawn from
U.S. academic institutions and government agencies, with a few experts invited from India,
China, and France to provide a broader perspective on international programs and activities and
opportunities for collaboration. These research priorities also build upon the previously
developed International IIOE-2 Science Plan and Implementation Strategy. Outcomes from the
workshop are condensed into five scientific themes: Upwelling, inter-ocean exchanges,
monsoon dynamics, inter-basin contrasts, marine geology and the deep ocean. Each theme is
identified with priority questions that the U.S. research community would like to address and the
measurements that need to be made in the Indian Ocean to address them.We thank the following organizations and programs for financial contributions, support
and endorsement: the U.S. National Oceanic and Atmospheric Administration; the U.S.
Ocean Carbon and Biogeochemistry program funded by the National Science
Foundation and the National Aeronautics and Space Administration; the NASA Physical
Oceanography Program; Scripps Institution of Oceanography; and the Indo-US Science
and Technology Forum
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