Whole Grain Products, Fish and Bilberries Alter Glucose and Lipid Metabolism in a Randomized, Controlled Trial: The Sysdimet Study

Due to the growing prevalence of type 2 diabetes, new dietary solutions are needed to help improve glucose and lipid metabolism in persons at high risk of developing the disease. Herein we investigated the effects of low-insulin-response grain products, fatty fish, and berries on glucose metabolism and plasma lipidomic profiles in persons with impaired glucose metabolism.Altogether 106 men and women with impaired glucose metabolism and with at least two other features of the metabolic syndrome were included in a 12-week parallel dietary intervention. The participants were randomized into three diet intervention groups: (1) whole grain and low postprandial insulin response grain products, fatty fish three times a week, and bilberries three portions per day (HealthyDiet group), (2) Whole grain enriched diet (WGED) group, which includes principally the same grain products as group (1), but with no change in fish or berry consumption, and (3) refined wheat breads (Control). Oral glucose tolerance, plasma fatty acids and lipidomic profiles were measured before and after the intervention. Self-reported compliance with the diets was good and the body weight remained constant. Within the HealthyDiet group two hour glucose concentration and area-under-the-curve for glucose decreased and plasma proportion of (n-3) long-chain PUFAs increased (False Discovery Rate p-values <0.05). Increases in eicosapentaenoic acid and docosahexaenoic acid associated curvilinearly with the improved insulin secretion and glucose disposal. Among the 364 characterized lipids, 25 changed significantly in the HealthyDiet group, including multiple triglycerides incorporating the long chain (n-3) PUFA.The results suggest that the diet rich in whole grain and low insulin response grain products, bilberries, and fatty fish improve glucose metabolism and alter the lipidomic profile. Therefore, such a diet may have a beneficial effect in the efforts to prevent type 2 diabetes in high risk persons.ClinicalTrials.gov NCT00573781

Differences in cow's milk composition between Iceland and the other Nordic countries and possible connections to public health

To access publisher full text version of this article. Please click on the hyperlink in Additional Link fieldBackground: The Icelandic bovine herd has been isolated for over 1100 years. Knowledge is needed about how its milk constituents differ from those of milk in the other Nordic countries, where cattle have been interbred with other European races. As milk and dairy products comprise a substantial part of food intake, especially in children, variations in cow's milk composition may be of value when considering environmental factors in public health. Regional variation in milk composition may explain contradictory results from studies on milk consumption and aetiology of diseases, type 1 diabetes mellitus and cardiovascular disease. Objective: To investigate differences in milk composition, particularly substances suggested to influence public health. Design: Analyses of the proteins ß-casein and ß-lactoglobulin, as well as fatty acid profiles and nitrates, were performed in samples of cow's milk as sold to consumers, at four different times during 1 year in three different regions in Iceland and in the capital areas of the other countries. Results: The Icelandic milk was significantly (p<0.05) lower in ß-casein fractions A1 and B and higher in the A2 fraction, lower in ß-lactoglobulin B and higher in A (p<0.001), had less than half in n-6/n-3 ratio and was higher in the very long-chain n-3 fatty acids and conjugated linoleic acid. It was slightly higher in saturated fatty acids. No significant difference was seen in the total amount of ß-caseins, ß-lactoglobulins or nitrates. Conclusions: Although slightly higher in saturated fatty acids, the Icelandic milk has a composition of proteins and fatty acids that may be associated with health benefits