Examining consent for interventional research in potential deceased organ donors: a narrative review

In the last decade, research in transplant medicine has focused on developing interventions in the management of the deceased organ donor to improve the quality and quantity of transplantable organs. Despite the promise of interventional donor research, there remain debates about the ethics of this research, specifically regarding gaining research consent. Here, we examine the concerns and ambiguities around consent for interventional donor research, which incorporate questions about who should consent for interventional donor research and what people are being asked to consent for. We highlight the US and UK policy responses to these concerns and argue that, whereas guidance in this area has done much to clarify these ambiguities, there is little consideration of the nature, practicalities and context around consent in this area, particularly regarding organ donors and their families. We review wider studies of consent in critical care research and social science studies of consent in medical research, to gain a broader view of consent in this area as a relational and contextual process. We contend a lack of consideration has been given to: what it might mean to consent to interventional donor research; how families, patients and health professionals might experience providing and seeking this consent; who is best placed to have these discussions; and the socio‐institutional contexts affecting these processes. Further, empirical research is required to establish an ethical and sensitive model for consent in interventional donor research, ensuring the principles enshrined in research ethics are met and public trust in organ donation is maintained

Raman spectroscopy with ultrashort coherent excitation. Narrowing of spectral lines beyond the dephasing linewidth

Spectroscopists are constantly faced with the task of improved spectral resolution. Two points are of major interest: (i) The precise frequency of the quantized transition and (ii) the detection of new neighboring transitions. Besides experimental factors the ultimate spectral resolution is determined by the inherent linewidth of the transition. Optical spectroscopists have to deal with different line-broadening processes; for instance with the Doppler effect or with collision broadening in gases, with dephasing processes in condensed systems and with the population relaxation which results in the natural linewidth. In recent years, different novel techniques have been devised which provide spectral resolution beyond the transition linewidth. For instance, Doppler broadening can be eliminated by saturation spectroscopy or by two counter-propagating beams for two-photon transitions/I/. Even measurements beyond the natural linewidth have been performed taking biased signals from the fluorescent decay /2-5/. Techniques have been proposed where the difference between the decay rates of the two states rather than their sum determines the linewidth /6,7/, and narrowing of the natural linewidth by decaying-pulse excitation has been discussed /8/. Very recently, we have demonstrated substantial line narrowing of Raman type transitions in condensed phases /9-11/. The lines were broadened by vibrational dephasing. New information was obtained in congestedspectral regions

Hand pollination to increase seed-set of red helleborine Cephalanthera rubra in the Chiltern Hills, Buckinghamshire, England

In 2007 and in previous years, as part of ongoing attempts to improve red helleborine Cephalanthera rubra seed-set, hand pollination of florets has been undertaken at a small colony of this species in Buckinghamshire, southern England. Natural pollination rarely occurs (one mature pod recorded in 10 years) at this site. In 2007, hand pollination resulted in the production of four seed pods, of which one withered and died. Upon ripening, the three remaining pods were removed for attempted micropropagation of the seeds. Ongoing conservation management has probably benefited the solitary bee Chelostoma campanularum which now appears fairly plentiful at the site, but despite the presence of this red helleborine flower visitor, natural pollination remains virtually unrecorded at this locality; field observations suggest that C.campanularum is in fact probably not large enough to act as an effective red helleborine pollinator as it can slip in and out of the flowers without removing the pollinia, unlike it larger relative C.fuliginosum, absent from the UK but which is a known pollinator of red helleborine in continental Europe

Wind tunnel testing of low-drag airfoils

Results are presented for the measured performance recently obtained on several airfoil concepts designed to achieve low drag by maintaining extensive regions of laminar flow without compromising high-lift performance. The wind tunnel results extend from subsonic to transonic speeds and include boundary-layer control through shaping and suction. The research was conducted in the NASA Langley 8-Ft Transonic Pressure Tunnel (TPT) and Low Turbulence Pressure Tunnel (LTPT) which have been developed for testing such low-drag airfoils. Emphasis is placed on identifying some of the major factors influencing the anticipated performance of low-drag airfoils

Experimental Potentials for the XΣ+2 and AΠ2 States of NaHe

Experimental potentials for the XΣ+2 and AΠ2 states of the NaHe molecule are presented. The potentials are generated from the temperature dependence of the red wing of the Na resonance line perturbed by He. For the AΠ2 state an unexpectedly large value is obtained for De=480(50) cm−1at Re=4.4(2)a0. The physical basis for this result, which indicates an important role for the internal structure of the rare gas in determining the repulsive part of the alkali-rare-gas interaction, is discussed

Demography of sea lamprey (Petromyzon marinus) ammocoete populations in relation to potential spawning-migration obstructions

Copyright © 2017 John Wiley & Sons, Ltd. Recent advances in the understanding of lamprey migrations have led to concerns over the impacts of obstructions on the demography of many species. This study investigated sea lamprey (Petromyzon marinus) larvae (ammocoetes) in two adjacent but contrasting rivers, both designated Special Areas of Conservation under the EC Habitats Directive (92/43/EEC), one (the River Wye) with a small number of potential migration obstructions in its upper reaches and one (the River Usk) with obstacles along its course. The geographical distributions, densities and age structures of the ammocoete populations were examined in relation to the locations of potential obstructions to the spawning migrations of anadromous adults. A minimum of three age classes was recorded as far as 200 km upstream of the mouth of the River Wye (93% of the length of the mainstem), demonstrating that adults regularly migrate to the upper reaches of the catchment (downstream of a natural waterfall). By contrast, sea lamprey ammocoetes appeared to be absent (in suitable habitat) from 20 km (17%) of the River Usk, and there was a reduction in density, prevalence and the number of age classes upstream of two putative spawning-migration obstructions. This study highlights some of the potential impacts of habitat fragmentation by obstructions on the spawning migrations of anadromous species, as inferred from ammocoete demography. When used in combination to compare contiguous reaches, ammocoete densities, prevalence and age structure may be a useful indicator of which structures are likely to be important migration obstructions, and where further studies or mitigation efforts should be focused. It is likely that passage past some obstructions is enhanced if high river levels occur during the spawning migration, but there is a need to facilitate passage during all conditions, to improve access to under-exploited spawning and nursery areas

Focusing a fountain of neutral cesium atoms with an electrostatic lens triplet

An electrostatic lens with three focusing elements in an alternating-gradient configuration is used to focus a fountain of cesium atoms in their ground (strong-field-seeking) state. The lens electrodes are shaped to produce only sextupole plus dipole equipotentials which avoids adding the unnecessary nonlinear forces present in cylindrical lenses. Defocusing between lenses is greatly reduced by having all of the main electric fields point in the same direction and be of nearly equal magnitude. The addition of the third lens gave us better control of the focusing strength in the two transverse planes and allowed focusing of the beam to half the image size in both planes. The beam envelope was calculated for lens voltages selected to produced specific focusing properties. The calculations, starting from first principles, were compared with measured beam sizes and found to be in good agreement. Application to fountain experiments, atomic clocks, and focusing polar molecules in strong-field-seeking states is discussed.Comment: 8 pages 10 figure

How Do Predatory Lending Laws Influence Mortgage Lending in Urban Areas? A Tale of Two Cities

This paper examines the effects of predatory lending laws in the cities of Chicago and Philadelphia. The level of mortgage activity in each of the cities is compared during the pre- and post-legislative periods relative to other parts of the state to assess the impact of localized legislation. In Chicago, where the predatory lending law focused on banks, a subprime origination in the city was found to be more likely to be made by a nonbank after the passage of the law. In Philadelphia, however, where the predatory legislation was aimed at all financial service providers, a decline was observed in the likelihood of a subprime loan being originated in the city during the post-legislation period, with the minority and low-income market segments experiencing the largest reduction.