Supplementation of iron alone and combined with vitamins improves haematological status, erythrocyte membrane fluidity and oxidative stress in anaemic pregnant women

Pregnancy is a condition exhibiting increased susceptibility to oxidative stress, and Fe plays a central role in generating harmful oxygen species. The objective of the present study is to investigate the changes in haematological status, oxidative stress and erythrocyte membrane fluidity in anaemic pregnant women after Fe supplementation with and without combined vitamins. The study was a 2 months double-blind, randomised trial. Pregnant women (n 164) were allocated to four groups: group C was the placebo control group; group I was supplemented daily with 60 mg Fe (ferrous sulphate) daily; group IF was supplemented daily with Fe plus 400 µg folic acid; group IM was supplemented daily with Fe plus 2 mg retinol and 1 mg riboflavin, respectively. After the 2-month trial, Hb significantly increased by 15·8, 17·3 and 21·8 g/l, and ferritin by 2·8, 3·6 and 11·0 µg/l, in the I, IF and IM groups compared with placebo. Polarisation (¿) and microviscosity (¿) decreased significantly in other groups compared with placebo, indicating an increase in membrane fluidity. Significant decreases of ¿ and ¿ values compared with group C were 0·033 and 0·959 for group I, 0·037 and 1·074 for group IF and 0·064 and 1·865 for group IM, respectively. In addition, significant increases of glutathione peroxidase activities and decreases of malondialdehyde were shown in all treated groups, as well as increases of plasma retinol and urine riboflavin in group IM. The findings show that supplementation with Fe and particularly in combination with vitamins could improve the haematological status as well as oxidative stress and erythrocyte membrane fluidit

The Extremely Luminous Quasar Survey (ELQS) in the SDSS footprint I.: Infrared Based Candidate Selection

Studies of the most luminous quasars at high redshift directly probe the evolution of the most massive black holes in the early Universe and their connection to massive galaxy formation. However, extremely luminous quasars at high redshift are very rare objects. Only wide area surveys have a chance to constrain their population. The Sloan Digital Sky Survey (SDSS) has so far provided the most widely adopted measurements of the quasar luminosity function (QLF) at $z>3$. However, a careful re-examination of the SDSS quasar sample revealed that the SDSS quasar selection is in fact missing a significant fraction of $z\gtrsim3$ quasars at the brightest end. We have identified the purely optical color selection of SDSS, where quasars at these redshifts are strongly contaminated by late-type dwarfs, and the spectroscopic incompleteness of the SDSS footprint as the main reasons. Therefore we have designed the Extremely Luminous Quasar Survey (ELQS), based on a novel near-infrared JKW2 color cut using WISE AllWISE and 2MASS all-sky photometry, to yield high completeness for very bright ($m_{\rm{i}} < 18.0$) quasars in the redshift range of $3.0\leq z\leq5.0$. It effectively uses random forest machine-learning algorithms on SDSS and WISE photometry for quasar-star classification and photometric redshift estimation. The ELQS will spectroscopically follow-up $\sim 230$ new quasar candidates in an area of $\sim12000\,\rm{deg}^2$ in the SDSS footprint, to obtain a well-defined and complete quasars sample for an accurate measurement of the bright-end quasar luminosity function at $3.0\leq z\leq5.0$. In this paper we present the quasar selection algorithm and the quasar candidate catalog.Comment: 16 pages, 8 figures, 9 tables; ApJ in pres

A refined volume-of-fluid algorithm for capturing sharp fluid interfaces on arbitrary meshes

This paper presents a new volume-of-fluid scheme (M-CICSAM), capable of capturing abrupt interfaces on meshes of arbitrary topology, which is a modification to the compressive interface capturing scheme for arbitrary meshes (CICSAM) proposed in the recent literature. Without resort to any explicit interface reconstruction, M-CICSAM is able to precisely model the complex free surface deformation, such as interface rupture and coalescence. By theoretical analysis, it is shown that the modified CICSAM overcomes three inherent drawbacks of the original CICSAM, concerning the basic differencing schemes, the switching strategy between the compressive downwind and diffusive high-resolution schemes, and the far-upwind reconstruction technique on arbitrary unstructured meshes. To evaluate the performance of the newly proposed scheme, several classic interface capturing methods developed in the past decades are compared with M-CICSAM in four test problems. The numerical results clearly demonstrate that M-CICSAM produces more accurate predictions on arbitrary meshes, especially at high Courant numbers, by reducing the numerical diffusion and preserving the interface shape.The authors gratefully acknowledge the financial support provided by the National Natural Science Foundation of China (Grant No. 51279082) and the State Key Laboratory of Hydroscience and Engineering of Tsinghua University (Grant No. 2013-KY-3).This is the accepted manuscript version. The final version is available from Elsevier at http://www.sciencedirect.com/science/article/pii/S0021999114004501

Disks around massive young stellar objects: are they common?

We present K-band polarimetric images of several massive young stellar objects at resolutions $\sim$ 0.1-0.5 arcsec. The polarization vectors around these sources are nearly centro-symmetric, indicating they are dominating the illumination of each field. Three out of the four sources show elongated low-polarization structures passing through the centers, suggesting the presence of polarization disks. These structures and their surrounding reflection nebulae make up bipolar outflow/disk systems, supporting the collapse/accretion scenario as their low-mass siblings. In particular, S140 IRS1 show well defined outflow cavity walls and a polarization disk which matches the direction of previously observed equatorial disk wind, thus confirming the polarization disk is actually the circumstellar disk. To date, a dozen massive protostellar objects show evidence for the existence of disks; our work add additional samples around MYSOs equivalent to early B-type stars.Comment: 9 pages, including 2 figures, 1 table, to appear on ApJ

BZ-MC-BP Model for Jet Production from Black Hole Accretion Disc

Three energy mechanisms invoking large-scale magnetic fields are incorporated in a model to interpret jet production in black hole (BH) systems, i.e., the Blandford-Znajek (BZ), the magnetic coupling (MC) and Blandford-Payne (BP) processes. These energy mechanisms can coexist in BH accretion disc based on the magnetic field configurations constrained by the screw instability, provided that the BH spin and the power-law index indicating the variation of the magnetic field at an accretion disc are greater than some critical values. In this model the jets are driven by the BZ process in the Poynting flux regime and by the BP process in the hydromagnetic regime, being consistent with the spine/sheath jet structure observed in BH sources of stellar and supermassive size.Comment: 9 pages, 6 figures, accepted by MNRA

Making graphene visible

Microfabrication of graphene devices used in many experimental studies currently relies on the fact that graphene crystallites can be visualized using optical microscopy if prepared on top of silicon wafers with a certain thickness of silicon dioxide. We study graphene's visibility and show that it depends strongly on both thickness of silicon dioxide and light wavelength. We have found that by using monochromatic illumination, graphene can be isolated for any silicon dioxide thickness, albeit 300 nm (the current standard) and, especially, approx. 100 nm are most suitable for its visual detection. By using a Fresnel-law-based model, we quantitatively describe the experimental data without any fitting parameters.Comment: Since v1: minor changes to text and figures to improve clarity; references added. Submitted to Applied Physics Letters, 30-Apr-07. 3 pages, 3 figure

Amplification and adaptation of centromeric repeats in polyploid switchgrass species.

Centromeres in most higher eukaryotes are composed of long arrays of satellite repeats from a single satellite repeat family. Why centromeres are dominated by a single satellite repeat and how the satellite repeats originate and evolve are among the most intriguing and long-standing questions in centromere biology. We identified eight satellite repeats in the centromeres of tetraploid switchgrass (Panicum virgatum). Seven repeats showed characteristics associated with classical centromeric repeats with monomeric lengths ranging from 166 to 187 bp. Interestingly, these repeats share an 80-bp DNA motif. We demonstrate that this 80-bp motif may dictate translational and rotational phasing of the centromeric repeats with the cenH3 nucleosomes. The sequence of the last centromeric repeat, Pv156, is identical to the 5S ribosomal RNA genes. We demonstrate that a 5S ribosomal RNA gene array was recruited to be the functional centromere for one of the switchgrass chromosomes. Our findings reveal that certain types of satellite repeats, which are associated with unique sequence features and are composed of monomers in mono-nucleosomal length, are favorable for centromeres. Centromeric repeats may undergo dynamic amplification and adaptation before the centromeres in the same species become dominated by the best adapted satellite repeat