A Student at Hope College in the Preparatory School, R. H. Joldersma, Wrote a Report in the Student Publication, the Excelsiora, on the Death of Albertus C. Van Raalte

A student at Hope College in the Preparatory School, R. H. Joldersma, wrote a report in the student publication, the Excelsiora, on the death of Albertus C. Van Raalte. The student made much of the fact that Van Raalte\u27s death occurred on election day. When the death of V.R. was announced the school\u27s classes were dismissed for the rest of the week. Friday, the day of the funeral was beautiful. The funeral cortege was very long, seventy six carriage in addition to the formal line up of city council members, etc. After Dr. Crispell had closed with prayer, we left the Cemetery fully convinced that a great man had fallen. The death of V.R. must have made a great impression on the students. The account is hand written and consists of six pages.https://digitalcommons.hope.edu/vrp_1870s/1289/thumbnail.jp

Cyclooxygenase-2 inhibition delays the attainment of peak woven bone formation following four-point bending in the rat

Fracture healing is retarded in the presence of cyclooxygenase-2 (COX-2) inhibitors, demonstrating an important role of COX-2 in trauma-induced woven bone adaptation. The aim of this experiment was to determine the influence of COX-2 inhibition on the remodeling and consolidation of non-traumatic woven bone produced by mechanical loading. A periosteal woven bone callus was initiated in the right tibia of female Wistar rats following a single bout of four-point-bending, applied as a haversine wave for 300 cycles at a frequency of 2Hz and a magnitude of 65N. Daily injections of Vehicle (VEH: polyethyleneglycol) or the COX-2 inhibitor, DFU (2.0 mg.kg-1 and 0.02mg.kg-1 i.p.), commenced 7 days postloading, and tibiae were examined 2, 3, 4 and 5 weeks postloading. Tibiae were dissected, embedded in polymethylmethacrylate and sectioned for histomorphometric analysis of periosteal woven bone. No significant difference in peak woven bone area was observed between DFU-treated and VEH rats. But treatment with DFU resulted in a temporal defect in woven bone formation, where the achievement of peak woven bone area was delayed by one week. Woven bone remodeling was observed in DFU-treated rats at 21 days post-loading, demonstrating that remodeling of the periosteal callus is not prevented in the presence of a COX-2 inhibitor in the rat. We conclude that COX-2 inhibition does not significantly disrupt the mechanism of woven bone remodeling, but alters its timing

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