Adsorption and binding dynamics of graphene-supported phospholipid membranes using the QCM-D technique

We report on the adsorption dynamics of phospholipid membranes on graphene-coated substrates using the quartz crystal microbalance with dissipation monitoring (QCM-D) technique. We compare the lipid vescle interaction and membranne formation on gold and silicon dioxide QCM crystal surfaces with their graphene oxide (GO) and reduced (r)GO coated counterparts, and report on the different lipid structures obtained. We establish graphene derivative coatings as support surfaces with tuneable hydrophobicity for the formation of controllable lipid structures. One structure of interest formed are lipid monolayer membrannes which were formed on rGO, which are otherwise challenging to produce. We also demonstrate and monitor biotin-avidin binding on such a membranne, which will then serve as a platform for a wide range of biosensing applications. The QCM-D technique could be extended to both fundamental studies and applications of other covalent and non-covalent interactions in 2-dimensional materials

From training to artisanal practice : rethinking choreographic relationships in modern dance

In the first part of the twentieth century early modern dancers created both a new art form and the forms of group social organisation that were its condition of possibility. This paper critically examines the balletic and disciplinary ‘training’ model of dancer formation and proposes that the assumption of training in dance can obscure other ways of understanding dance-making relationships and other values in early modern dance. An ‘artisanal’ mode of production and knowledge transmission based on a non-binary relationship between ‘master’ and apprentice and occurring in a quasi-domestic and personalised space of some intimacy is proposed as a more pertinent way to think the enabling conditions of modern dance creation

Large Igneous Provinces and their mafic-ultramafic intrusions

Here we provide an overview of the range of settings for mafic-ultramafic layered intrusions as part of the plumbing system of Large Igneous Provinces, and address the metallogenic implications

Interaction standards for biophysics: anti-lysozyme nanobodies

From Springer Nature via Jisc Publications RouterHistory: received 2020-10-14, rev-recd 2021-03-01, registration 2021-03-22, accepted 2021-03-22, pub-electronic 2021-04-11, online 2021-04-11, pub-print 2021-05Publication status: PublishedFunder: Wellcome Trust; doi: http://dx.doi.org/10.13039/100004440; Grant(s): 203128/Z/16/ZAbstract: There is a significant demand in the molecular biophysics community for robust standard samples. They are required by researchers, instrument developers and pharmaceutical companies for instrumental quality control, methodological development and in the design and validation of devices, diagnostics and instrumentation. To-date there has been no clear consensus on the need and type of standards that should be available and different research groups and instrument manufacturers use different standard systems which significantly hinders comparative analysis. One of the major objectives of the Association of Resources for Biophysical Research in Europe (ARBRE) is to establish a common set of standard samples that can be used throughout the biophysics community and instrument developers. A survey was circulated among ARBRE members to ascertain the requirements of laboratories when using standard systems and the results are documented in this article. In summary, the major requirements are protein samples which are cheap, relatively small, stable and have different binding strengths. We have developed a panel of sdAb’s or ‘nanobodies’ against hen-egg white lysozyme with different binding strengths and suitable stability characteristics. Here we show the results of the survey, the selection procedure, validation and final selection of a panel of nanobody interaction standards

Immunogenicity of vaccination against influenza, Streptococcus pneumoniae and Haemophilus influenzae type B in patients with multiple myeloma

Vaccination against influenza and Streptococcus pneumoniae is recommended for elderly and immunocompromised individuals. However, there is little information concerning the efficacy of vaccination in specific groups of patients. In this study, 52 patients underwent vaccination against influenza, S. pneumoniae and Haemophilus influenzae type b (Hib) as they attended hospital outpatient clinics. Serum was analysed prior to vaccination and 4–6 weeks afterwards. Antibody titres against S. pneumoniae and Hib were compared with reference values corresponding to the geometric mean titres of a healthy UK population. For influenza vaccination, haemagglutination inhibition (HI) titres were measured against three inactivated strains; a titre of ≥ 1/40 was considered protective. No patient had protective titres to all three antigens prior to vaccination and 41 patients (85%) had titres < 1/40 to all 3 strains. Post vaccination only 9/48 patients (19%) achieved protective antibody titres. Resistance to S. pneumoniae and response to Pneumovax II was also poor: prevaccination, 45 patients (93%) had suboptimal antibody titres and in 26/43 patients (61%) titres remained low post vaccination. Resistance to Hib and response to vaccination was comparable with the healthy adult UK population. These results question the practice of routine influenza and pneumococcal vaccination in myeloma patients. © 2000 Cancer Research Campaig

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ABC series from the BMJABC of Monitoring Drug Therapy. By ]. K. Aronson, M. Hardman and D. J. M. Reynolds. Pp. ix + 38. Illustrated. £9. BM]. 1993. (ABC books are available through the Book Division, MASA Publications, tel. (021) 531-3081.) ISBN 0-7279-0791-3.ABC of AIDS. 3rd ed. Ed. by Michael Wadler. Pp. 86. Illustrated. £15. BM]. 1993. ISB T 0-7279-0761-1.ABC of Dermatology. 2nd ed. By P. K. Buxton. Pp. 98. Illustrated. £15. BM]. 1993. ISBN 0-7279-0777-8.ABC of Healthy Travel 4th ed. By Eric Walker, Glyn Williams and Fiona Raeside. Pp. 49. Illustrated. £12. BM]. 1993. ISBN 0-7279-0762-X.ABC of Otolaryngology. 3rd ed. By Harold Ludman. Pp. 58. Illustrated. £11. BM]. 1993. ISH- T 0-7279-0765-4.ABC of Colorectal Diseases. Ed. by D. ]. Jones and M. H. Irving. Pp. 103. Illustrated. £15. BM]. 1993. ISBN 07279- 9755-7.Tissue bankingMusculoskeletal Tissue Banking. By William W. Tornford (with contributions by James H. Forsell, Allen P. MacKenzie and D. Michael Stron). Pp. xiii + 240. Illustrated.94,50. Raven Press. 1993. ISBN 0-88167-995-X.Tobacco smokingLegislative Action to COIIlbat the World Tobacco Epidemic. 2nd ed. R. Roemer. pp. xiii + 297. SFr.59. in developing counrries: SFr.41,30. WHO. 1993. ISBN 92-4156157-2.There's Sunlight in My Leaf. Biography of Nicotiana tabacum. By Johan Fourie. Pp. 69. Marius du Plooy Communications. 1992. ISBN 0-620-17064-6.NutritionFood, Facts and Figures. The Complete South African Guide. Pp. 135. Illustrated. RI9,99. Oxford University Press (In collaboration with the Medical Research Council). 1992. ISBN 0-19-570736-2.OrthopeadicsOrthopaedic Diagnosis and ManagelDent: A Guide to the Care of Orthopaedic Patients. By Boyd S. Goldie. Pp. xviii + 247. £17,95. Blackwell Scientific Publications.1992. ISBN 0-632-03043-7.Biliary stonesBailliere's Clinical Gastroenterology. International Practice and Research. Diagnosis and Management of Biliary Stones. Ed. by M. Sackmann. Pp. x + 200. lllustrated. £27,50. Harcourt Brace Jovanovich. 1992. ISBN 0-7020-1 625-X.Molecular and cell biologyBasic Molecular and Cell Biology. 2nd ed. Pp. vii + 209. illustrated. BM}. 1993. ISBN 0-7279-0772-7.Nutritional anaemiasNutritional Anaemias. Nestle Nutritional Workshop Series. Vol. 30. Ed by Samuel }. Fomon and Stanley Zlotkin. Pp. xii + 220. 75. New York: Raven Press. 1992

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