Dispositional antecedents of promotive and prohibitive voice

We propose that promotive voice, or the expression of suggestions for improving work practices in the organization, and prohibitive voice, or the expression of warnings about factors that can harm the organization, are differentially influenced by employees’ dispositional inclination to be approach and avoidance oriented. Drawing on multisource survey data from 291 employees and their managers, we found that approach orientation had positive relationship with promotive voice and negative relationship with prohibitive voice. By contrast, avoidance orientation had positive relationship with prohibitive voice and negative relationship with promotive voice. Further, voice role expectations, or employees’ beliefs about the extent to which a particular form of voice is expected from them in their daily work, moderated the effects of approach and avoidance orientations. Highlighting the unique nature of voice as a behavior that is especially sensitive to situational cues, the effects of approach and avoidance orientations on promotive and prohibitive voice were stronger when role expectations for that form of voice were weaker. The theoretical implications of these findings are discussed

Cancer and thrombosis: Managing the risks and approaches to thromboprophylaxis

Patients with cancer are at increased risk of venous thromboembolism (VTE) compared with patients without cancer. This results from both the prothrombotic effects of the cancer itself and iatrogenic factors, such as chemotherapy, radiotherapy, indwelling central venous devices and surgery, that further increase the risk of VTE. Although cancer-associated thrombosis remains an important cause of morbidity and mortality, it is often underdiagnosed and undertreated. However, evidence is accumulating to support the use of low-molecular-weight heparins (LMWHs) in the secondary prevention of VTE in patients with cancer. Not only have LMWHs been shown to be at least as effective as coumarin derivatives in this setting, but they have a lower incidence of complications, including bleeding, and are not associated with the practical problems of warfarin therapy. Furthermore, a growing number of studies indicate that LMWHs may improve survival among patients with cancer due to a possible antitumor effect. Current evidence suggests that LMWHs should increasingly be considered for the long-term management of VTE in patients with cancer

Co-axial dual-core resonant leaky fibre for optical amplifiers

We present a co-axial dual-core resonant leaky optical fibre design, in which the outer core is made highly leaky. A suitable choice of parameters can enable us to resonantly couple power from the inner core to the outer core. In a large-core fibre, such a resonant coupling can considerably increase the differential leakage loss between the fundamental and the higher order modes and can result in effective single-mode operation. In a small-core single-mode fibre, such a coupling can lead to sharp increase in the wavelength dependent leakage loss near the resonant wavelength and can be utilized for the suppression of amplified spontaneous emission and thereby gain equalization of an optical amplifier. We study the propagation characteristics of the fibre using the transfer matrix method and present an example of each, the large-mode-area design for high power amplifiers and the wavelength tunable leakage loss design for inherent gain equalization of optical amplifiers.Comment: 6 page

The association between patterns of atrial fibrillation, anticoagulation, and cardiovascular events.

AIMS: Guidelines do not recommend to take pattern of atrial fibrillation (AF) into account for the indication of anticoagulation (AC). We assessed AF pattern and the risk of cardiovascular events during 2-years of follow-up. METHODS AND RESULTS: We categorized AF as paroxysmal, persistent, or permanent in 29 181 patients enrolled (2010-15) in the Global Anticoagulant Registry In the FIELD of AF (GARFIELD-AF). We used multivariable Cox regression to assess the risks of stroke/systemic embolism (SE) and death across patterns of AF, and whether this changed with AC on outcomes. Atrial fibrillation pattern was paroxysmal in 14 344 (49.2%), persistent in 8064 (27.6%), and permanent 6773 (23.2%) patients. Median CHA2DS2-VASc, GARFIELD-AF, and HAS-BLED scores assessing the risk of stroke/SE and/or bleeding were similar across AF patterns, but the risk of death, as assessed by the GARFIELD-AF risk calculator, was higher in non-paroxysmal than in paroxysmal AF patterns. During 2-year follow-up, after adjustment, non-paroxysmal AF patterns were associated with significantly higher rates of all-cause death, stroke/SE, and new/worsening congestive heart failure (CHF) than paroxysmal AF in non-anticoagulated patients only. In anticoagulated patients, a significantly higher risk of death but not of stroke/SE and new/worsening CHF persisted in non-paroxysmal compared with paroxysmal AF patterns. CONCLUSION: In non-anticoagulated patients, non-paroxysmal AF patterns were associated with higher risks of stroke/SE, new/worsening HF and death than paroxysmal AF. In anticoagulated patients, the risk of stroke/SE and new/worsening HF was similar across all AF patterns. Thus AF pattern is no longer prognostic for stroke/SE when patients are treated with anticoagulants. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Group cohesion benefits individuals who express prejudice, but harms their group

When someone expresses prejudice against an outgroup, how negatively do we judge the prejudiced individual and his or her ingroup? Previous lines of research suggest that the answer depends on the ingroup’s entitativity -- i.e., how cohesive it is -- but they make different predictions about whether entitativity should increase or decrease outside observers’ negative reactions to prejudice. We resolve this tension by demonstrating divergent consequences of entitativity for prejudiced individuals versus their groups. Mediational and experimental data from six studies (two pre-registered; N = 2,455) support two hypotheses: Entitativity increases how responsible the group seems for its member’s prejudice, which in turn decreases how unacceptable observers find the member’s behavior and how much they condemn her (H1), but which also increases how much they condemn the group (H2). Thus, entitativity can grant individuals a license to express prejudice but can damage their group’s reputation

HEALTH STATUS OF CHILDREN UNDER SCHOOL HEALTH SERVICES IN DOIWALA BLOCK, DEHRADUN

Background -The introduction of school health services in India dates back to 1909, when school children in the city of Baroda were given the first medical examination. School Health programme ,promoting basic check up of school children for a variety of health related problems, is a systematic effort in raising awareness about health issues among school children and their families. Good health increases enrollment and reduces absenteeism. It also ensures attendance of the poorest and most disadvantaged children to school, many of whom are girls. Aim- To study the morbidity status of the school children & elicit relationship of healthy habits with morbidity pattern. Study Type- Observational study Methodology- A cross sectional survey to find out the morbidity pattern was conducted on 757 school children (340 boys and 417girls), aged 5-16 years studying in class I-VIII in five different schools of Doiwala, Dehradun under Rural Health training centre, Rajeev Nagar. Results- Overall students attendance was 78.2%. Clinical anaemia was higher in Girls (46.7%) as compared to Boys (34.1%). Worm infestation was higher in boys (65.1%) as compared to Girls(57.3%). Over all abnormal Visual acquity(8.5%) or eye abnormality (14%) was noticed among study subjects. Dental Caries (53.1%) and dermatitis (16.3%) were more in boys. Healthy habits like daily bathing (82.6%), daily teeth brushing (61.1%), mouth rinsing after meal (53%) and hair clean/combed (80.2%) were more in girls as compared to boys while trimmed nail was equally (55%) noticed among both the groups. Conclusion- Morbidities found amongst students are basically due to low awareness & negligent behaviour about personal hygiene are the key areas of concern and by active involvement of school teachers improvement in personal hygiene of school children and reduction in related morbidities can be achieved

A STUDY ON ASHA –A CHANGE AGENT OF THE SOCIETY

Background: National Rural Health Mission started in the state of Uttarakhand with the objective to address the health needs of rural population, especially the vulnerable section of the society. Under this scheme, ASHA has been identified as one of the key strategy for wider coverage of services, considering her the first port of call for any health related demands, especially women and children. Objective: To find out the biosocial profile of ASHA and services provided by them. Material & Methods: A descriptive study was conducted in Imlikhera Block of Haridwar district in 2008 participated by all (150) ASHA. Data was collected by trained investigators of Rural Development Institute which is also a State ASHA resource Centre. Results: Maximum (42%) ASHA were in 26-30 Years of age group. However, 23% ASHA were in less than 25 years of age which is below than the stipulated selection criteria. About 6.3% ASHAs were not fulfilling the educational criteria of selection (education upto 8th class). Study reported that majority of ASHA consider care of pregnant women, vaccination and family planning as their prime services. 42% ASHA reported that they think this work can pave their ways for future employment. Conclusion: Supervisory body should see that selection of ASHA should be as per stipulated criteria and they should be sensitized about their major role of motivator & activist, for creating awareness and demand generation in the society

The Clinical Significance of Interleukin-6 in Heart Failure:Results from the BIOSTAT-CHF Study

Aims: Inflammation is a central process in the pathophysiology of heart failure (HF), but trials targeting tumour necrosis factor (TNF)‐α were largely unsuccessful. Interleukin (IL)‐6 is an important inflammatory mediator and might constitute a potential pharmacologic target in HF. However, little is known regarding the association between IL‐6 and clinical characteristics, outcomes and other inflammatory biomarkers in HF. We thus aimed to identify and characterize these associations. Methods and results: Interleukin‐6 was measured in 2329 patients [89.4% with a left ventricular ejection fraction (LVEF) ≤ 40%] of the BIOSTAT‐CHF cohort. The primary outcome was all‐cause mortality and HF hospitalization during 2 years, with all‐cause, cardiovascular (CV), and non‐CV death as secondary outcomes. Approximately half (56%) of all included patients had plasma IL‐6 values greater than the previously determined 95th percentile of normal values at baseline. Elevated N‐terminal pro‐brain natriuretic peptide, procalcitonin and hepcidin, younger age, TNF‐α/IL‐1‐related biomarkers, or having iron deficiency, atrial fibrillation and LVEF > 40% independently predicted elevated IL‐6 levels. IL‐6 independently predicted the primary outcome [HR (95% confidence interval) per doubling: 1.16 (1.11–1.21), P < 0.001], all‐cause mortality [1.22 (1.16–1.29), P < 0.001] and CV as well as non‐CV mortality [1.16 (1.09–1.24), P < 0.001; 1.31 (1.18–1.45), P < 0.001], but did not improve discrimination in previously published risk models. Conclusions: In a large, heterogeneous cohort of HF patients, elevated IL‐6 levels were found in more than 50% of patients and were associated with iron deficiency, reduced LVEF, atrial fibrillation and poorer clinical outcomes. These findings warrant further investigation of IL‐6 as a potential therapeutic target in specific HF subpopulations