The mPower Study, Parkinson Disease Mobile Data Collected Using Researchkit

Current measures of health and disease are often insensitive, episodic, and subjective. Further, these measures generally are not designed to provide meaningful feedback to individuals. The impact of high-resolution activity data collected from mobile phones is only beginning to be explored. Here we present data from mPower, a clinical observational study about Parkinson disease conducted purely through an iPhone app interface. The study interrogated aspects of this movement disorder through surveys and frequent sensor-based recordings from participants with and without Parkinson disease. Benefitting from large enrollment and repeated measurements on many individuals, these data may help establish baseline variability of real-world activity measurement collected via mobile phones, and ultimately may lead to quantification of the ebbs-and-flows of Parkinson symptoms. App source code for these data collection modules are available through an open source license for use in studies of other conditions. We hope that releasing data contributed by engaged research participants will seed a new community of analysts working collaboratively on understanding mobile health data to advance human health

Second primary cancer risk - the impact of applying different definitions of multiple primaries: results from a retrospective population-based cancer registry study

Background: There is evidence that cancer survivors are at increased risk of second primary cancers. Changes in the prevalence of risk factors and diagnostic techniques may have affected more recent risks.<p></p> Methods: We examined the incidence of second primary cancer among adults in the West of Scotland, UK, diagnosed with cancer between 2000 and 2004 (n = 57,393). We used National Cancer Institute Surveillance Epidemiology and End Results and International Agency for Research on Cancer definitions of multiple primary cancers and estimated indirectly standardised incidence ratios (SIR) with 95% confidence intervals (CI).<p></p> Results: There was a high incidence of cancer during the first 60 days following diagnosis (SIR = 2.36, 95% CI = 2.12 to 2.63). When this period was excluded the risk was not raised, but it was high for some patient groups; in particular women aged <50 years with breast cancer (SIR = 2.13, 95% CI = 1.58 to 2.78), patients with bladder (SIR = 1.41, 95% CI = 1.19 to 1.67) and head & neck (SIR = 1.93, 95% CI = 1.67 to 2.21) cancer. Head & neck cancer patients had increased risks of lung cancer (SIR = 3.75, 95% CI = 3.01 to 4.62), oesophageal (SIR = 4.62, 95% CI = 2.73 to 7.29) and other head & neck tumours (SIR = 6.10, 95% CI = 4.17 to 8.61). Patients with bladder cancer had raised risks of lung (SIR = 2.18, 95% CI = 1.62 to 2.88) and prostate (SIR = 2.41, 95% CI = 1.72 to 3.30) cancer.<p></p> Conclusions: Relative risks of second primary cancers may be smaller than previously reported. Premenopausal women with breast cancer and patients with malignant melanomas, bladder and head & neck cancers may benefit from increased surveillance and advice to avoid known risk factors

UMA REFLEXÃO SOBRE A ATUAÇÃO DA COORDENAÇÃO NA RETENÇÃO DE DISCENTES: O CASO DO CURSO DE ADMINISTRAÇÃO DO CAMPUS I DA UNIVERSIDADE FEDERAL DA PARAÍBA

Neste artigo, busca-se refletir sobre a atuação da Coordenação na retenção de discentes do curso de Administração do Campus I da Universidade Federal da Paraíba. Para isso, foram identificados os principais motivos que têm levado os discentes a não concluírem seu curso no prazo regular, bem como a relação que tais motivos têm com a Coordenação do Curso. É um estudo de caso de caráter qualitativo-quantitativo e finalidade descritiva. Intencionalmente, os sujeitos da pesquisa foram os alunos que matriculados nos semestres 2008.1 e 2008.2. Para abordá-los, foi enviado por e-mail, um questionário elaborado no Google Docs, com perguntas abertas e fechadas acerca do perfil do participante, da relação com o estudo, o trabalho e a Coordenação. Após o prazo de duas semanas, de um total de 135 alunos, 53 foram respondentes. Esses dados foram tratados à luz da técnica de análise categorial. As reprovações em disciplinas, o choque de horários de disciplinas, a dificuldade em conseguir orientação para o trabalho de conclusão e curso e a falta de tempo para a dedicação aos estudos foram os motivos mais frequentemente manifestados. Mas os alunos desconhecem a esfera de atuação da Coordenação, que detecta problemas, concebe possíveis soluções, mas não dispõe de ingerência para solução dos mesmos, dependendo desta maneira de apoio de outros espaços institucionais

Factors Contributing to Chronic Student Absenteeism in Low Socioeconomic Urban Elementary Schools: An Analysis of Multiple Stakeholders’ Perspectives

The purpose of this study was to examine factors contributing to chronic student absenteeism in two lower socioeconomic urban elementary schools. This qualitative study was guided by two research questions: 1) What are stakeholders’ perspectives on chronic absenteeism at Mission and Lincoln Elementaries? and 2) What changes to practice or policy could improve attendance at Mission and Lincoln Elementaries? Research question one was answered via data collected from interviews with purposefully selected parents, teachers, administrators, social workers, and nurses. Analysis of interview data led to the identification of three themes which reflect stakeholders’ perspectives on chronic absenteeism at Mission and Lincoln Elementaries. These interrelated themes include: factors contributing to absenteeism (i.e., lack of parental concern, financial hardships, parent or child health problems, lack of a reliable support system, and familial trauma and mental health problems), parent accountability, and entrenched deficit perspectives. Research question two was answered via interviews with participants and pre-existing textual data (e.g., school policies, school attendance meetings, attendance guides). Data revealed strategies currently implemented by Mission and Lincoln Elementaries to improve attendance and strategies which could be implemented or adapted to better address students and families’ needs. These findings were used to develop specific recommendations for addressing chronic student absenteeism at Mission and Lincoln Elementaries

Factors Contributing to Chronic Student Absenteeism in Low Socioeconomic Urban Elementary Schools: An Analysis of Multiple Stakeholders’ Perspectives

The purpose of this study was to examine factors contributing to chronic student absenteeism in two lower socioeconomic urban elementary schools. This qualitative study was guided by two research questions: 1) What are stakeholders’ perspectives on chronic absenteeism at Mission and Lincoln Elementaries? and 2) What changes to practice or policy could improve attendance at Mission and Lincoln Elementaries? Research question one was answered via data collected from interviews with purposefully selected parents, teachers, administrators, social workers, and nurses. Analysis of interview data led to the identification of three themes which reflect stakeholders’ perspectives on chronic absenteeism at Mission and Lincoln Elementaries. These interrelated themes include: factors contributing to absenteeism (i.e., lack of parental concern, financial hardships, parent or child health problems, lack of a reliable support system, and familial trauma and mental health problems), parent accountability, and entrenched deficit perspectives. Research question two was answered via interviews with participants and pre-existing textual data (e.g., school policies, school attendance meetings, attendance guides). Data revealed strategies currently implemented by Mission and Lincoln Elementaries to improve attendance and strategies which could be implemented or adapted to better address students and families’ needs. These findings were used to develop specific recommendations for addressing chronic student absenteeism at Mission and Lincoln Elementaries

Study of intrinsic spin and orbital Hall effects in Pt based on a (6s, 6p, 5d) tight-binding model

We study the origin of the intrinsic spin Hall conductivity (SHC) and the d-orbital Hall conductivity (OHC) in Pt based on a multiorbital tight-binding model with spin-orbit interaction. We find that the SHC reaches 1000 \hbar/e\Omega cm when the resistivity \rho is smaller than ~10 \mu\Omega cm, whereas it decreases to 300 \hbar/e\Omega cm when \rho ~ 100 \mu\Omega cm. In addition, the OHC is still larger than the SHC. The origin of huge SHE and OHE in Pt is the large ``effective magnetic flux'' that is induced by the interorbital transition between d_{xy}- and d_{x2-y2}-orbitals with the aid of the strong spin-orbit interaction.Comment: 5 page

Elevated tph2 mRNA expression in a rat model of chronic anxiety

BACKGROUND: Allelic variations in TPH2, the gene encoding tryptophan hydroxylase 2, the rate-limiting enzyme for brain serotonin (5-HT) biosynthesis, may be genetic predictors of panic disorder and panic responses to panicogenic challenges in healthy volunteers. To test the hypothesis that tph2 mRNA is altered in chronic anxiety states, we measured tph2 expression in an established rat model of panic disorder. METHODS: We implanted 16 adult, male rats with bilateral guide cannulae and then primed them with daily injections of the corticotropin-releasing factor (CRF) receptor agonist, urocortin 1 (UCN1, 6 fmoles/100 nl per side, n = 8) or vehicle (n = 8) into the basolateral amygdaloid complex (BL) for 5 consecutive days. Anxiety-like behavior was assessed, 24 hr prior to and 48 hr following priming, in the social interaction (SI) test. A third group (n = 7) served as undisturbed home cage controls. All rats were killed 3 days after the last intra-BL injection to analyze tph2 and slc6a4 (gene encoding the serotonin transporter, SERT) mRNA expression in the dorsal raphe nucleus (DR), the main source of serotonergic projections to anxiety-related brain regions, using in situ hybridization histochemistry. RESULTS: UCN1 priming increased anxiety-related behavior in the SI test compared to vehicle-injected controls and elevated tph2, but not slc6a4, mRNA expression in DR subregions, including the ventrolateral DR/ventrolateral periaqueductal gray (DRVL/VLPAG), a subregion previously implicated in control of panic-related physiologic responses. Tph2 mRNA expression in the DRVL/VLPAG was correlated with increased anxiety-related behavior. CONCLUSION: Our data support the hypothesis that chronic anxiety states are associated with dysregulated tph2 expression

An introduction to mixed models for experimental psychology

This chapter describes a class of statistical model that is able to account for most of the cases of nonindependence that are typically encountered in psychological experiments, linear mixed-effects models, or mixed models for short. It introduces the concepts underlying mixed models and how they allow accounting for different types of nonindependence that can occur in psychological data. The chapter discusses how to set up a mixed model and how to perform statistical inference with a mixed model. The most important concept for understanding how to estimate and how to interpret mixed models is the distinction between fixed and random effects. One important characteristic of mixed models is that they allow random effects for multiple, possibly independent, random effects grouping factors. Mixed models are a modern class of statistical models that extend regular regression models by including random-effects parameters to account for dependencies among related data points