Contribution of the antibiotic chloramphenicol and its analogues as precursors of dichloroacetamide and other disinfection byproducts in drinking water

Dichloroacetamide (DCAcAm), a disinfection byproduct, has been detected in drinking water. Previous research showed that amino acids may be DCAcAm precursors. However, other precursors may be present. This study explored the contribution of the antibiotic chloramphenicol (CAP) and two of its analogues (thiamphenicol, TAP; florfenicol, FF) (referred to collectively as CAPs), which occur in wastewater-impacted source waters, to the formation of DCAcAm. Their formation yields were compared to free and combined amino acids, and they were investigated in filtered waters from drinking-water-treatment plants, heavily wastewater-impacted natural waters, and secondary effluents from wastewater treatment plants. CAPs had greater DCAcAm formation potential than two representative amino acid precursors. However, in drinking waters with ng/L levels of CAPs, they will not contribute as much to DCAcAm formation as the μg/L levels of amino acids. Also, the effect of advanced oxidation processes (AOPs) on DCAcAm formation from CAPs in real water samples during subsequent chlorination was evaluated. Preoxidation of CAPs with AOPs reduced the formation of DCAcAm during postchlorination. The results of this study suggest that CAPs should be considered as possible precursors of DCAcAm, especially in heavily wastewater-impacted waters

Automatic Detection of GUI Design Smells: The Case of Blob Listener

International audienceGraphical User Interfaces (GUIs) intensively rely on event-driven programming: widgets send GUI events, which capture users' interactions, to dedicated objects called controllers. Controllers implement several GUI listeners that handle these events to produce GUI commands. In this work, we conducted an empirical study on 13 large Java Swing open-source software systems. We study to what extent the number of GUI commands that a GUI listener can produce has an impact on the change-and fault-proneness of the GUI listener code. We identify a new type of design smell, called Blob listener that characterizes GUI listeners that can produce more than two GUI commands. We show that 21 % of the analyzed GUI controllers are Blob listeners. We propose a systematic static code analysis procedure that searches for Blob listener that we implement in InspectorGuidget. We conducted experiments on six software systems for which we manually identified 37 instances of Blob listener. InspectorGuidget successfully detected 36 Blob listeners out of 37. The results exhibit a precision of 97.37 % and a recall of 97.59 %. Finally, we propose coding practices to avoid the use of Blob listeners

Introduction

What are the strategies, modalities and aspirations of island-based, stateless nationalist and regionalist parties in the twenty-first century? Political independence is now easier to achieve, even by the smallest of territories; yet, it is not so likely to be pursued with any vigour by the world's various persisting sub-national (and mainly island) jurisdictions. Theirs is a pursuit of different expressions of sub-national autonomy, stopping short of independence. And yet, a number of independence referenda are scheduled, including one looming in Scotland in autumn 2014

The Hole in the Whole: Sovereignty, Shared Sovereignty, and International Law

Ideally, a body of law comprises a set of coherent and consistent rules. These rules contribute to the creation of an environment that is predictable, efficacious, and just. Most international lawyers hope, expect, or believe that such a body of law can exist for the international system. This is a fool\u27s errand

Power and Constraint

John Bolton raises two distinct sets of questions about global governance: the first involves the creation of supranational authority structures; the second, the penetration of the American domestic political process, especially by transnational non-governmental organizations ( TNGOs ). Neither of these involves international legal sovereignty, the right of the United States, or any state, to freely enter into agreements with other states. Both do involve issues associated with the nature and autonomy of domestic authority structures, the ability of political actors to determine the kinds of political institutions within which they will function, and the decisions that emerge from these institutions. The rule that one state should not interfere in the internal affairs of another, first articulated by the international jurist Emer de Vattel at the end of the 18th century, has become one of the defining norms of sovereignty. It is, however, a norm that has been frequently violated, sometimes as a result of coercion, for example the Soviet Union\u27s invasion of Czechoslovakia in 1968 and the American occupation of Panama in 1989, and sometimes as a result of voluntary agreements, such as the 1957 Treaty of Rome and subsequent accords that have created the European Union. Moreover, some political structures are inherently more open to official or unofficial external influence either because there are multiple avenues of access, as is the case with the United States, or because they are weakly institutionalized, as is the case in several African countries. Although domestic autonomy is a widely recognized rule it might, or might not, serve the interests of a specific state. John Bolton worries that the permeability of the American political process may be a threat to the United States. I suggest instead that, given the inordinate international power of the United States, the ability of external actors, including TNGOs, to involve themselves in American decision-making may make it easier to accomplish American objectives by reducing the temptation to balance against, rather than cooperate with, the United States

Work-Related Mental Health and Job Performance: Can Mindfulness Help?

Work-related mental health issues such as work-related stress and addiction to work impose a significant health and economic burden to the employee, the employing organization, and the country of work more generally. Interventions that can be empirically shown to improve levels of work-related mental health – especially those with the potential to concurrently improve employee levels of work performance – are of particular interest to occupational stakeholders. One such broad-application interventional approach currently of interest to occupational stakeholders in this respect is mindfulness-based interventions (MBIs). Following a brief explication of the mindfulness construct, this paper critically discusses current research directions in the utilization of mindfulness in workplace settings and assesses its suitability for operationalization as an organization-level work-related mental health intervention. By effecting a perceptual-shift in the mode of responding and relating to sensory and cognitive-affective stimuli, employees that undergo mindfulness training may be able to transfer the locus of control for stress from external work conditions to internal metacognitive and attentional resources. Therefore, MBIs may constitute cost-effective organization-level interventions due to not actually requiring any modifications to human resource management systems and practises. Based on preliminary empirical findings and on the outcomes of MBI studies with clinical populations, it is concluded that MBIs appear to be viable interventional options for organizations wishing to improve the mental health of their employees

Global Governance Behind Closed Doors : The IMF Boardroom, the Enhanced Structural Adjustment Facility, and the Intersection of Material Power and Norm Change in Global Politics

Up on the 12th floor of its 19th Street Headquarters, the IMF Board sits in active session for an average of 7 hours per week. Although key matters of policy are decided on in the venue, the rules governing Boardroom interactions remain opaque, resting on an uneasy combination of consensual decision-making and weighted voting. Through a detailed analysis of IMF Board discussions surrounding the Enhanced Structural Adjustment Facility (ESAF), this article sheds light on the mechanics of power in this often overlooked venue of global economic governance. By exploring the key issues of default liability and loan conditionality, I demonstrate that whilst the Boardroom is a more active site of contestation than has hitherto been recognized, material power is a prime determinant of both Executive Directors’ preferences and outcomes reached from discussions. And as the decisions reached form the backbone of the ‘instruction sheet’ used by Fund staff to guide their everyday operational decisions, these outcomes—and the processes through which they were reached—were factors of primary importance in stabilizing the operational norms at the heart of a controversial phase in the contemporary history of IMF concessional lending

The future of sovereignty in multilevel governance Europe: a constructivist reading

Multilevel governance presents a depiction of contemporary structures in EU Europe as consisting of overlapping authorities and competing competencies. By focusing on emerging non-anarchical structures in the international system, hence moving beyond the conventional hierarchy/anarchy dichotomy to distinguish domestic and international arenas, this seems a radical transformation of the familiar Westphalian system and to undermine state sovereignty. Paradoxically, however, the principle of sovereignty proves to be resilient despite its alleged empirical decline. This article argues that social constructivism can explain the paradox, by considering sovereign statehood as a process-dependent institutional fact, and by showing that multilevel governance can feed into this process