Effect of short-term lycopene supplementation and postprandial dyslipidemia on plasma antioxidants and biomarkers of endothelial health in young, healthy individuals

The objective of this study was to test the hypothesis that the effect of a high-fat meal (HFm) on plasma lipid-soluble antioxidants and biomarkers of vascular oxidative stress and inflammation would be attenuated by short-term lycopene supplementation in young healthy subjects. Following restriction of lycopene-containing foods for 1-wk (LYr), blood was collected in a fasting state and 3 h after a HFm and a low-fat meal (LFm) in N = 18 men aged 23 ± 2 years, and after a HFm only in N = 9 women aged 23 ± 1 years. Blood was also sampled pre- and post-meals following 1-wk of 80 mg/day lycopene supplementation (LYs) under continued dietary LYr. In the fasting state, LYs compared with LYr not only evoked a >2-fold increase in plasma lycopene but also increased plasma β-carotene and α-tocopherol (p < 0.01), though LYs did not affect plasma nitrate/nitrite (biomarker of nitric oxide), malondialdehyde (biomarker of lipid oxidative stress), vascular- and intercellular-adhesion molecules or C-reactive protein (biomarkers of inflammation). Contrary to the hypothesis, the HFm-induced dyslipidemic state did not affect plasma malondialdehyde, C-reactive protein, or adhesion molecules in either LYr or LYs. Both the HFm and LFm were associated with decreases in the nitric oxide metabolites nitrate/nitrite and lipid-soluble antioxidants (p < 0.05). The data revealed that 1-wk of LYs increased plasma lycopene, β-carotene, and α-tocopherol yet despite these marked changes to the plasma lipid-soluble antioxidant pool, biomarkers of vascular oxidative stress and inflammation were unaffected in the fasted state as well as during dyslipidemia induced by a HFm in young healthy subjects

Multi-frame Measurement Fusion for State Estimation

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“An autobiography in which I do not appear”: The Seductive Self in the Poetry of Robert Kroetsch

The article discusses selected works by the Western Canadian writer Robert Kroetsch (1927–2011) within the context of the biography battles which peaked during the 1990s. Kroetsch played a critical role in the formation and honing of a distinctive Prairie literary tradition in Canada, and we discuss a series of his poetic and other works published from the 1970s to 2010 which resonate with concerns raised within life-writing and life-writing criticism in the nineties. We focus on the almost obsessive concern with the relationships between self and other, and the seemingly contradictory denial of a stable self which mark the life writing debate of the decade; both evident in all of Kroetsch's writing. Raising the relation between space and selfhood to the fore, the article argues that Kroetsch's work not only questions our ability to know another through writing, but even to know the self. At the same time, we argue that the glimpses of a seemingly stable, autobiographical self that emerge in his writings speak to the seductiveness of gaining insights into the machinations of another person's mind, tempting Kroetsch again and again to ponder writing “an autobiography in which I do not appear”.</p