Comparative Analysis Of Zebrafish And Planarian Model Systems For Developmental Neurotoxicity Screens Using An 87-Compound Library

There is a clear need to establish and validate new methodologies to more quickly and efficiently screen chemicals for potential toxic effects, particularly on development. The emergence of alternative animal systems for rapid toxicology screens presents valuable opportunities to evaluate how systems complement each other. In this article, we compare a chemical library of 87-compounds in two such systems, developing zebrafish and freshwater planarians, by screening for developmental neurotoxic effects. We show that the systems’ toxicological profiles are complementary to each other, with zebrafish yielding more detailed morphological endpoints and planarians more behavioral endpoints. Overall, zebrafish was more sensitive to this chemical library, yielding 86/87 hits, compared to 50/87 hits in planarians. The difference in sensitivity could not be attributed to molecular weight, Log Kow or the bioconcentration factor. Of the 87 chemicals, 28 had previously been evaluated in mammalian developmental neuro- (DNT), neuro- or developmental toxicity studies. Of the 28, 20 were hits in the planarian, and 27 were hits in zebrafish. Eighteen of the 28 had previously been identified as DNT hits in mammals and were highly associated with activity in zebrafish and planarian behavioral assays in this study. Only 1 chemical (out of 28) was a false negative in both zebrafish and planarian systems. Differences in endpoint coverage and system sensitivity illustrate the value of a dual systems approach to rapidly query a large chemical-bioactivity space and provide weight-of-evidence for prioritization of chemicals for further testing

Review of finite fields: Applications to discrete Fourier, transforms and Reed-Solomon coding

An attempt is made to provide a step-by-step approach to the subject of finite fields. Rigorous proofs and highly theoretical materials are avoided. The simple concepts of groups, rings, and fields are discussed and developed more or less heuristically. Examples are used liberally to illustrate the meaning of definitions and theories. Applications include discrete Fourier transforms and Reed-Solomon coding

Powertrain modelling for engine stop-start dynamics and control of micro/mild hybrid construction machines

Engine stop-start control is considered as the key technology for micro/mild hybridisation of vehicles and machines. To utilize this concept, especially for construction machines, the engine is desired to be started in such a way that the operator discomfort can be minimized. To address this issue, this paper aims to develop a simple powertrain modelling approach for engine stop-start dynamic analysis and an advanced engine start control scheme newly applicable for micro/mild hybrid construction machines. First, a powertrain model of a generic construction machine is mathematically developed in a general form which allows to investigate the transient responses of the system during the engine cranking process. Second, a simple parameterisation procedure with a minimum set of data required to characterise the dynamic model is presented. Third, a model- based adaptive controller is designed for the starter to crank the engine quickly and smoothly without the need of fuel injection while the critical problems of machine noise, vibration and harshness can be eliminated. Finally, the advantages and effectiveness of the proposed modelling and control approaches have been validated through numerical simulations. The results imply that with the limited data set for training, the developed model works better than a high fidelity model built in AMESim while the adaptive controller can guarantee the desired cranking performance

Excitation spectroscopy of single quantum dots at tunable positive, neutral and negative charge states

We present a comprehensive study of the optical transitions and selection rules of variably charged single self-assembled InAs/GaAs quantum dots. We apply high resolution polarization sensitive photoluminescence excitation spectroscopy to the same quantum dot for three different charge states: neutral and negatively or positively charged by one additional electron or hole. From the detailed analysis of the excitation spectra, a full understanding of the single-carrier energy levels and the interactions between carriers in these levels is extracted for the first time.Comment: 8 pages, 5 figure

Heun Functions and the energy spectrum of a charged particle on a sphere under magnetic field and Coulomb force

We study the competitive action of magnetic field, Coulomb repulsion and space curvature on the motion of a charged particle. The three types of interaction are characterized by three basic lengths: l_{B} the magnetic length, l_{0} the Bohr radius and R the radius of the sphere. The energy spectrum of the particle is found by solving a Schr\"odinger equation of the Heun type, using the technique of continued fractions. It displays a rich set of functioning regimes where ratios \frac{R}{l_{B}} and \frac{R}{l_{0}} take definite values.Comment: 12 pages, 5 figures, accepted to JOPA, november 200

Investigation of phonon behavior in Pr2NiMnO6 by micro-Raman spectroscopy

The temperature dependence of phonon excitations and the presence of spin phonon coupling in polycrystalline Pr2NiMnO6 samples were studied using micro-Raman spectroscopy and magnetometry. Magnetic properties show a single ferromagnetic-to-paramagnetic transition at 228 K and a saturation magnetization close to 4.95 \muB/f.u.. Three distinct Raman modes at 657, 642, and 511 cm-1 are observed. The phonon excitations show a clear hardening due to anharmonicity from 300 K down to 10 K. Further, temperature dependence of the 657 cm-1 mode shows only a small softening. This reflects the presence of a relatively weak spin-phonon coupling in Pr2NiMnO6 contrary to other double perovskites previously studied.Comment: 10 pages, 4 fig

Healthcare use for diarrhoea and dysentery in actual and hypothetical cases, Nha Trang, Viet Nam.

To better understand healthcare use for diarrhoea and dysentery in Nha Trang, Viet Nam, qualitative interviews with community residents and dysentery case studies were conducted. Findings were supplemented by a quantitative survey which asked respondents which healthcare provider their household members would use for diarrhoea or dysentery. A clear pattern of healthcare-seeking behaviours among 433 respondents emerged. More than half of the respondents self-treated initially. Medication for initial treatment was purchased from a pharmacy or with medication stored at home. Traditional home treatments were also widely used. If no improvement occurred or the symptoms were perceived to be severe, individuals would visit a healthcare facility. Private medical practitioners are playing a steadily increasing role in the Vietnamese healthcare system. Less than a quarter of diarrhoea patients initially used government healthcare providers at commune health centres, polyclinics, and hospitals, which are the only sources of data for routine public-health statistics. Given these healthcare-use patterns, reported rates could significantly underestimate the real disease burden of dysentery and diarrhoea

Challenges of micro/mild hybridisation for construction machinery and applicability in UK

In recent years, micro/mild hybridisation (MMH) is known as a feasible solution for powertrain development with high fuel efficiency, less energy use and emission and, especially, low cost and simple installation. This paper focuses on the challenges of MMH for construction machines and then, pays attention to its applicability to UK construction machinery. First, hybrid electric configurations are briefly reviewed; and technological challenges towards MMH in construction sector are clearly stated. Second, the current development of construction machinery in UK is analysed to point out the potential for MMH implementation. Thousands of machines manufactured in UK have been sampled for the further study. Third, a methodology for big data capturing, compression and mining is provided for a capable of managing and analysing effectively performances of various construction machine types. By using this method, 96% of data memory can be reduced to store the huge machine data without lacking the necessary information. Forth, an advanced decision tool is built using a fuzzy cognitive map based on the big data mining and knowledge from experts to enables users to define a target machine for MMH utilization. The numerical study with this tool on the sampled machines has been done and finally realized that one class of heavy excavators is the most suitable to apply MMH technology

Parents\u27 Goals: An Analysis of Therapist Reasoning

Purpose: Illustrate the use of DDDM to develop parent-identified goals for occupational therapy and to identify underlying sensory integration factors hypothesized to be impacting participation