Membrane fluidity and temperature sensing are coupled via circuitry comprised of Ole1, Rsp5, and Hsf1 in Candida albicans

Peer reviewedPublisher PD

Surviving the heat of the moment : a fungal pathogens perspective

Peer reviewedPublisher PD

Material Flow Analysis: Outcome Focus (MFA:OF) for Elucidating the Role of Infrastructure in the Development of a Liveable City

Engineered infrastructures (i.e., utilities, transport & digital) underpin modern society. Delivering services via these is especially challenging in cities where differing infrastructures form a web of interdependencies. There must be a step change in how infrastructures deliver services to cities, if those cities are to be liveable in the future (i.e., provide for citizen wellbeing, produce less CO2 & ensure the security of the resources they use). Material Flow Analysis (MFA) is a useful methodology for understanding how infrastructures transfer resources to, within and from cities and contribute to the city’s metabolism. Liveable Cities, a five-year research programme was established to identify & test radical engineering interventions leading to liveable cities of the future. In this paper, the authors propose an outcome-focussed variation on the MFA methodology (MFA: OF), evidenced through work on the resource flows of Birmingham, UK. These flows include water, energy, food & carbon-intensive materials (e.g., steel, paper, glass), as well as their associated waste. The contribution MFA: OF makes to elucidating the interactions & interdependencies between the flows is highlighted and suggestions are made for how it can contribute to the (radical) rethinking of the engineered infrastructure associated with such flow

Energy efficient engine: Turbine intermediate case and low-pressure turbine component test hardware detailed design report

A four stage, low pressure turbine component has been designed to power the fan and low pressure compressor system in the Energy Efficient Engine. Designs for a turbine intermediate case and an exit guide vane assembly also have been established. The components incorporate numerous technology features to enhance efficiency, durability, and performance retention. These designs reflect a positive step towards improving engine fuel efficiency on a component level. The aerodynamic and thermal/mechanical designs of the intermediate case and low pressure turbine components are presented and described. An overview of the predicted performance of the various component designs is given

Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals

Peer reviewedPublisher PD

Posttranslational modifications of proteins in the pathobiology of medically relevant fungi

Peer reviewedPublisher PD

Development and testing of a unique carousel wind tunnel to experimentally determine the effect of gravity and the interparticle force on the physics of wind-blown particles

In the study of planetary aeolian processes the effect of gravity is not readily modeled. Gravity appears in the equations of particle motion along with the interparticle forces but the two are not separable. A wind tunnel that perimits multiphase flow experiments with wind blown particles at variable gravity was built and experiments were conducted at reduced gravity. The equations of particle motion initiation (saltation threshold) with variable gravity were experimentally verified and the interparticle force was separated. A uniquely design Carousel Wind Tunnel (CWT) allows for the long flow distance in a small sized tunnel since the test section if a continuous loop and develops the required turbulent boundary layer. A prototype model of the tunnel where only the inner drum rotates was built and tested in the KC-135 Weightless Wonder 4 zero-g aircraft. Future work includes further experiments with walnut shell in the KC-135 which sharply graded particles of widely varying median sizes including very small particles to see how interparticle force varies with particle size, and also experiments with other aeolian material