Brain Serotonin Synthesis in Adult Males Characterized by Physical Aggression during Childhood: A 21-Year Longitudinal Study

Adults exhibiting severe impulsive and aggressive behaviors have multiple indices of low serotonin (5-HT) neurotransmission. It remains unclear though whether low 5-HT mediates the behavior or instead reflects a pre-existing vulnerability trait.C-AMT bilaterally in the orbitofrontal cortex and self-reported more impulsiveness. Despite this, in adulthood there were no group differences in plasma tryptophan levels, genotyping, aggression, emotional intelligence, working memory, computerized measures of impulsivity, psychosocial functioning/adjustment, and personal and family history of mood and substance abuse disorders.These results force a re-examination of the low 5-HT hypothesis as central in the biology of violence. They suggest that low 5-HT does not mediate current behavior and should be considered a vulnerability factor for impulsive-aggressive behavior that may or may not be expressed depending on other biological factors, experience, and environmental support during development

Theological Education in Contemporary Africa

Part One addresses Theological Foundations. The five essays in this section deal with the Bible, Theology and Ecumenism. The subjects of theological methods, contextual hermeneutics, and appropriate curriculum are given special attention. Of course even foundational issues cannot be discussed in a vacuum and so each of the essays addresses these foundational subjects in the light of African realities. Part Two deals with Contemporary Issues. It is particularly in this section that the traditional themes in African theology have been somewhat displaced by concerns which are today very pressing indeed. Three essays are devoted to the question of HIV/AIDS. This disease, which has devastated the African continent, demands a theological and practical response from those who claim to follow Jesus Christ. If the churches do not respond to this crisis with energy and determination we should not be surprised if the next generation wonders whether the Gospel has the power which we claim that it has. Two essays address the question of Islam and Muslim-Christian Relations in Africa. The resurgence of Islam in the world today is a concern of many. For those who believe in Jesus, this is a challenge which demands much wisdom and love. How should we respond to our Muslim neighbours? What are appropriate and thoughtful ways to share the love of Christ? Two further essays appear under the title of The Marginalized. This could, of course, be a much large section. Those who suffer from AIDS could be included in this number, and one might have expected to see at least one essay on the place of women. In this volume, however, the disabled and youth are highlighted. Both groups are clearly in need of the attention of the churches, and both groups are clearly misunderstood and neglected. The final section of Part Two contains essays, which focus attention on Theological Paedagogy. All of the other contributions to this volume make suggestions and arguments about curriculum, resources, and issues of concern for theological educators. The causal aim of this book is that these essays may help us to reflect in an intentional way on the implications of contemporary realities for the future of theological education

Involvement of serotonin transporter gene polymorphisms (5-HTT) in impulsive behavior in the japanese population

The serotonergic pathway has been implicated in the pathogenesis of impulsivity, and sensitivity to aversive outcomes may be linked to serotonin (5-HT) levels. Polymorphisms in the gene that encodes the serotonin transporter (5-HTT), which have differential effects on the level of serotonin transmission, display alternate responses to aversive stimuli. However, recent studies have shown that 5-HT does not affect motor function, which suggests that the functioning of the serotonin-transporter-linked polymorphic region (5-HTTLPR) does not directly affect the behavioral regulatory process itself, but instead exerts an effect via the evaluation of the potential risk associated with particular behavioral outputs. The aim of the present study was to examine the effect of specific 5-HTTLPR genotypes on the motor regulatory process, as observed during a Go/Nogo punishment feedback task. 5-HTT gene-linked promoter polymorphisms were analyzed by polymerase chain reaction, using lymphocytes from 61 healthy Japanese volunteers. Impulsivity was defined as the number of commission errors (responding when one should not) made during a Go/Nogo task. We found that the s/s genotype group made fewer impulsive responses, specifically under aversive conditions for committing such errors, compared to those in the s/l group, without affecting overall motor inhibition. These results suggest that 5-HTTLPRs do not directly affect the behavioral regulatory process itself, but may instead exert an effect on the evaluation of potential risk. The results also indicate that under such aversive conditions, decreased expression of 5-HTT may promote motor inhibitory control

High Frequency Rheology Monitoring for Emulsion Stability Characterization

International audienc