472 research outputs found
Copper cable theft: revisiting the price–theft hypothesis
Objectives: To test the commonly espoused but little examined hypothesis that fluctuations in the price of metal are associated with changes in the volume of metal theft. Specifically, we analyze the relationship between the price of copper and the number of police recorded 'live’ copper cable thefts from the British railway network (2006 to 2012)
Temperature dependence of the resonance and low energy spin excitations in superconducting FeTeSe
We use inelastic neutron scattering to study the temperature dependence of
the low-energy spin excitations in single crystals of superconducting
FeTeSe ( K). In the low-temperature superconducting
state, the imaginary part of the dynamic susceptibility at the electron and
hole Fermi surfaces nesting wave vector ,
, has a small spin gap, a two-dimensional
neutron spin resonance above the spin gap, and increases linearly with
increasing for energies above the resonance. While the intensity
of the resonance decreases like an order parameter with increasing temperature
and disappears at temperature slightly above , the energy of the mode is
weakly temperature dependent and vanishes concurrently above . This
suggests that in spite of its similarities with the resonance in electron-doped
superconducting BaFe(Co,Ni)As, the mode in
FeTeSe is not directly associated with the superconducting
electronic gap.Comment: 7 pages, 6 figure
A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity
CACNA1I is a candidate schizophrenia risk gene. It encodes the pore-forming human CaV3.3 α1 subunit, a subtype of voltage-gated calcium channel that contributes to T-type currents. Recently, two de novo missense variations, T797M and R1346H, of hCaV3.3 were identified in individuals with schizophrenia. Here we show that R1346H, but not T797M, is associated with lower hCaV3.3 protein levels, reduced glycosylation, and lower membrane surface levels of hCaV3.3 when expressed in human cell lines compared to wild-type. Consistent with our biochemical analyses, whole-cell hCaV3.3 currents in cells expressing the R1346H variant were ~50% of those in cells expressing WT hCaV3.3, and neither R1346H nor T797M altered channel biophysical properties. Employing the NEURON simulation environment, we found that reducing hCaV3.3 current densities by 22% or more eliminates rebound bursting in model thalamic reticular nucleus (TRN) neurons. Our analyses suggest that a single copy of Chr22: 39665939G > A CACNA1I has the capacity to disrupt CaV3.3 channel-dependent functions, including rebound bursting in TRN neurons, with potential implications for schizophrenia pathophysiology
Self-gravitating clouds of generalized Chaplygin and modified anti-Chaplygin Gases
The Chaplygin gas has been proposed as a possible dark energy, dark matter
candidate. As a working fluid in a Friedmann-Robertson-Walker universe, it
exhibits early behavior reminiscent of dark matter, but at later times is more
akin to a cosmological constant. In any such universe, however, one can expect
local perturbations to form. Here we obtain the general equations for a
self-gravitating relativistic Chaplygin gas. We solve these equations and
obtain the mass-radius relationship for such structures, showing that only in
the phantom regime is the mass-radius relationship large enough to be a serious
candidate for highly compact massive objects at the galaxy core. In addition,
we study the cosmology of a modified anti-Chaplygin gas. A self-gravitating
cloud of this matter is an exact solution to Einstein's equations.Comment: 16 page
Field-Induced Magnetostructural Transitions in Antiferromagnetic Fe1+yTe1-xSx
The transport and structural properties of Fe1+yTe1-xSx (x=0, 0.05, and 0.10)
crystals were studied in pulsed magnetic fields up to 65 T. The application of
high magnetic fields results in positive magnetoresistance effect with
prominent hystereses in the antiferromagnetic state. Polarizing microscope
images obtained at high magnetic fields showed simultaneous occurrence of
structural transitions. These results indicate that magnetoelastic coupling is
the origin of the bicollinear magnetic order in iron chalcogenides.Comment: 5 pages, 5 figures, accepted for publication in Journal of the
Physical Society of Japa
Normal-State Spin Dynamics and Temperature-Dependent Spin Resonance Energy in an Optimally Doped Iron Arsenide Superconductor
The proximity of superconductivity and antiferromagnetism in the phase
diagram of iron arsenides, the apparently weak electron-phonon coupling and the
"resonance peak" in the superconducting spin excitation spectrum have fostered
the hypothesis of magnetically mediated Cooper pairing. However, since most
theories of superconductivity are based on a pairing boson of sufficient
spectral weight in the normal state, detailed knowledge of the spin excitation
spectrum above the superconducting transition temperature Tc is required to
assess the viability of this hypothesis. Using inelastic neutron scattering we
have studied the spin excitations in optimally doped BaFe1.85Co0.15As2 (Tc = 25
K) over a wide range of temperatures and energies. We present the results in
absolute units and find that the normal state spectrum carries a weight
comparable to underdoped cuprates. In contrast to cuprates, however, the
spectrum agrees well with predictions of the theory of nearly antiferromagnetic
metals, without complications arising from a pseudogap or competing
incommensurate spin-modulated phases. We also show that the temperature
evolution of the resonance energy follows the superconducting energy gap, as
expected from conventional Fermi-liquid approaches. Our observations point to a
surprisingly simple theoretical description of the spin dynamics in the iron
arsenides and provide a solid foundation for models of magnetically mediated
superconductivity.Comment: 8 pages, 4 figures, and an animatio
Three-Dimensional Fermi Surface of Overdoped La-Based Cuprates
We present a soft x-ray angle-resolved photoemission spectroscopy study of
the overdoped high-temperature superconductors LaSrCuO and
LaEuSrCuO. In-plane and out-of-plane components of
the Fermi surface are mapped by varying the photoemission angle and the
incident photon energy. No dispersion is observed along the nodal
direction, whereas a significant antinodal dispersion is identified.
Based on a tight-binding parametrization, we discuss the implications for the
density of states near the van-Hove singularity. Our results suggest that the
large electronic specific heat found in overdoped LaSrCuO can
not be assigned to the van-Hove singularity alone. We therefore propose quantum
criticality induced by a collapsing pseudogap phase as a plausible explanation
for observed enhancement of electronic specific heat
Spin density wave induced disordering of the vortex lattice in superconducting LaSrCuO
We use small angle neutron scattering to study the superconducting vortex
lattice in LaSrCuO as a function of doping and magnetic field.
We show that near optimally doping the vortex lattice coordination and the
superconducting coherence length are controlled by a van-Hove singularity
crossing the Fermi level near the Brillouin zone boundary. The vortex lattice
properties change dramatically as a spin-density-wave instability is approached
upon underdoping. The Bragg glass paradigm provides a good description of this
regime and suggests that SDW order acts as a novel source of disorder on the
vortex lattice.Comment: Accepted in Phys. Rev.
BRCA1 and BRCA2 mutations in a population-based study of male breast cancer
Background: The contribution of BRCA1 and BRCA2 to the incidence of male breast cancer (MBC)
in the United Kingdom is not known, and the importance of these genes in the increased risk of female
breast cancer associated with a family history of breast cancer in a male first-degree relative is unclear.
Methods: We have carried out a population-based study of 94 MBC cases collected in the UK. We
screened genomic DNA for mutations in BRCA1 and BRCA2 and used family history data from these
cases to calculate the risk of breast cancer to female relatives of MBC cases. We also estimated the
contribution of BRCA1 and BRCA2 to this risk.
Results: Nineteen cases (20%) reported a first-degree relative with breast cancer, of whom seven also
had an affected second-degree relative. The breast cancer risk in female first-degree relatives was 2.4
times (95% confidence interval [CI] = 1.4–4.0) the risk in the general population. No BRCA1 mutation
carriers were identified and five cases were found to carry a mutation in BRCA2. Allowing for a
mutation detection sensitivity frequency of 70%, the carrier frequency for BRCA2 mutations was 8%
(95% CI = 3–19). All the mutation carriers had a family history of breast, ovarian, prostate or
pancreatic cancer. However, BRCA2 accounted for only 15% of the excess familial risk of breast
cancer in female first-degree relatives.
Conclusion: These data suggest that other genes that confer an increased risk for both female and
male breast cancer have yet to be found
Progress in Neutron Scattering Studies of Spin Excitations in High-Tc Cuprates
Neutron scattering experiments continue to improve our knowledge of spin
fluctuations in layered cuprates, excitations that are symptomatic of the
electronic correlations underlying high-temperature superconductivity.
Time-of-flight spectrometers, together with new and varied single crystal
samples, have provided a more complete characterization of the magnetic energy
spectrum and its variation with carrier concentration. While the spin
excitations appear anomalous in comparison with simple model systems, there is
clear consistency among a variety of cuprate families. Focusing initially on
hole-doped systems, we review the nature of the magnetic spectrum, and
variations in magnetic spectral weight with doping. We consider connections
with the phenomena of charge and spin stripe order, and the potential
generality of such correlations as suggested by studies of magnetic-field and
impurity induced order. We contrast the behavior of the hole-doped systems with
the trends found in the electron-doped superconductors. Returning to hole-doped
cuprates, studies of translation-symmetry-preserving magnetic order are
discussed, along with efforts to explore new systems. We conclude with a
discussion of future challenges.Comment: revised version, to be published in JPSJ, 20 pages, 21 figure
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