Innovated Retractable Whiteboard

This research study featured an innovative retractable whiteboard. The researchers investigated the impact of an innovative retractable whiteboard on CTU-Pinamungajan Campus students' academic community engagement and learning, and consequently evaluated the acceptability and efficiency of the proposed adjustable whiteboard at CTU-Pinamungajan Campus in the school year 2023-2024. The convenience sample technique allowed for a total of 100 respondents to be selected. The study employed an experimental design and a quantitative research method. This determined the demographic profile of the respondents and their perspectives on the innovative retractable whiteboard in terms of its technical requirements, level of performance, and acceptability. We gathered the data using researcher-made questionnaires. We then tabulated and computed these data sets using a frequency table and a weighted mean. The results were based on the statistical treatment used, and the average yield indicates the level of interpretation. Findings revealed enhanced student engagement, improved learning outcomes, and a collaborative learning environment facilitated by the whiteboard. This was made evident by the aggregated mean values, which were interpreted as strongly agreeing, excellent, and highly acceptable. Based on the data, the researchers conclude that the respondents find the innovative retractable whiteboard useful, functional, efficient, and acceptable

The Knights templars

On spine : Rev. ed., 1876.Mode of access: Internet

Quantitative SARS-CoV-2 Serology in Children With Multisystem Inflammatory Syndrome (MIS-C)

OBJECTIVES: We aimed to measure severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological responses in children hospitalized with multisystem inflammatory syndrome in children (MIS-C) compared with those with coronavirus disease 2019 (COVID-19), those with Kawasaki disease (KD), and hospitalized pediatric controls. METHODS: From March 17, 2020, to May 26, 2020, we prospectively identified hospitalized children with MIS-C (n = 10), symptomatic COVID-19 (n = 10), and KD (n = 5) and hospitalized controls (n = 4) at Children’s Healthcare of Atlanta. With institutional review board approval, we obtained prospective and residual blood samples from these children and measured SARS-CoV-2 spike receptor-binding domain (RBD) immunoglobulin M and immunoglobulin G (IgG), full-length spike IgG, and nucleocapsid protein antibodies using quantitative enzyme-linked immunosorbent assays and SARS-CoV-2 neutralizing antibodies using live-virus focus-reduction neutralization assays. We statistically compared the log-transformed antibody titers among groups and performed linear regression analyses. RESULTS: All children with MIS-C had high titers of SARS-CoV-2 RBD IgG antibodies, which correlated with full-length spike IgG antibodies (R2 = 0.956; P &amp;lt; .001), nucleocapsid protein antibodies (R2 = 0.846; P &amp;lt; .001), and neutralizing antibodies (R2 = 0.667; P &amp;lt; .001). Children with MIS-C had significantly higher SARS-CoV-2 RBD IgG antibody titers (geometric mean titer 6800; 95% confidence interval 3495–13 231) than children with COVID-19 (geometric mean titer 626; 95% confidence interval 251–1563; P &amp;lt; .001), children with KD (geometric mean titer 124; 95% confidence interval 91–170; P &amp;lt; .001), and hospitalized controls (geometric mean titer 85; P &amp;lt; .001). All children with MIS-C also had detectable RBD immunoglobulin M antibodies, indicating recent SARS-CoV-2 infection. RBD IgG titers correlated with the erythrocyte sedimentation rate (R2 = 0.512; P &amp;lt; .046) and with hospital (R2 = 0.548; P = .014) and ICU lengths of stay (R2 = 0.590; P = .010). CONCLUSIONS: Quantitative SARS-CoV-2 serology may have a role in establishing the diagnosis of MIS-C, distinguishing it from similar clinical entities, and stratifying risk for adverse outcomes. </jats:sec

Serology in Children with Multisystem Inflammatory Syndrome (MIS-C) associated with COVID-19

ABSTRACTObjectivesWe aimed to measure SARS-CoV-2 serologic responses in children hospitalized with multisystem inflammatory syndrome (MIS-C) compared to COVID-19, Kawasaki Disease (KD) and other hospitalized pediatric controls.MethodsFrom March 17, 2020 - May 26, 2020, we prospectively identified hospitalized children at Children’s Healthcare of Atlanta with MIS-C (n=10), symptomatic PCR-confirmed COVID-19 (n=10), KD (n=5), and hospitalized controls (n=4). With IRB approval, we obtained prospective and residual blood samples from these children and measured SARS-CoV-2 spike (S) receptor binding domain (RBD) IgM and IgG binding antibodies by quantitative ELISA and SARS-CoV-2 neutralizing antibodies by live-virus focus reduction neutralization assay. We statistically compared the log-transformed antibody titers among groups and performed correlation analyses using linear regression.ResultsAll children with MIS-C had high titers of SARS-CoV-2 RBD IgG antibodies, which correlated strongly with neutralizing antibodies (R2=0.667, P&lt;0.001). Children with MIS-C had significantly higher SARS-CoV-2 RBD IgG antibody titers (geometric mean titer [GMT] 6800, 95%CI 3495-13231) than children with COVID-19 (GMT 626, 95%CI 251-1563, P&lt;0.001), children with KD (GMT 124, 95%CI 91-170, P&lt;0.001) and other hospitalized pediatric controls (GMT 85 [all below assay limit of detection], P&lt;0.001). All children with MIS-C also had detectable RBD IgM antibodies, indicating recent SARS-CoV-2 infection. RBD IgG titers correlated with erythrocyte sedimentation rate (ESR) (R2=0.512, P&lt;0.046) and with hospital and ICU lengths of stay (R2=0.590, P=0.010).ConclusionQuantitative SARS-CoV-2 RBD antibody titers may have a role in establishing the diagnosis of MIS-C, distinguishing it from other similar clinical entities, and stratifying risk for adverse outcomes.Table of Contents SummaryChildren with MIS-C have high antibody titers to the SARS-CoV-2 spike protein receptor binding domain, which correlate with neutralization, systemic inflammation, and clinical outcomes.What’s Known on This SubjectAlthough the clinical features of a multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 have been recently described, the serologic features of MIS-C are unknown.What This Study AddsIn this case series, all hospitalized children with MIS-C had significantly higher SARS-CoV-2 binding and neutralizing antibodies than children with COVID-19 or Kawasaki Disease. SARS-CoV-2 antibodies correlated with metrics of systemic inflammation and clinical outcomes, suggesting diagnostic and prognostic value.</jats:sec