6,801 research outputs found
Measuring the Performance of Underplatform Dampers for Turbine Blades by Rotating Laser Doppler Vibrometer
Underplatform friction dampers are commonly used to control the vibration level of turbine blades in order to prevent high-cycle fatigue failures. Experimental validation of highly non-linear response predictions obtained from FEM bladed disk models incorporating underplatform dampers models, has proved to be very difficult so as the assessment of the performance of a chosen design. In this paper, the effect of wedgeshaped underplatform dampers on the dynamics of a simple bladed disk under rotating conditions is measured and the effect of the excitation level on the UPDs performances is investigated at different number of the engine order excitation nearby resonance frequencies of the 1st blade bending modes of the system. The measurements are performed with an improved configuration of a rotating test rig, designed with a noncontact magnetic excitation and a non-contact rotating SLDV measurement syste
Nonlinear modal testing performed by pulsed-air jet excitation system
This paper presents a novel approach for testing structural component to nonlinear vibrations. Nowadays, nonlinear testing is mainly carried out by using electromagnetic shakers. These are efficient and powerful excitation systems which transmit the force by a rigid stinger and can be driven by different excitation signals. The rigid connection contributes to create mechanical impedance mismatch between the shaker and the test structure thus reducing the efficiency of the driving force. An alternative solution to shakers is represented by use of a pulsed air jet excitation method, which drives the force by a pulsed air-jets and therefore contactless. This condition eliminates the mechanical impedance mismatch with the test structure and the excitation can be more efficient than the one created by shakers. The pulsed air-jet excitation system is used to study nonlinear vibrations of composites components. These were designed to be mock-ups of fan blades the layup of which was varied for the three types of components used in this work. Tests were carried out by performing forced response and free decay measurements. The free decay type of test revealed interesting results and the novelty of using such an exciter for nonlinear testing. The major novelty consists of interrupting the air flow from a steady state condition and let happen the free decay, all these without experiencing undesired dynamics as experienced by contact excitatio
Finite driving rate and anisotropy effects in landslide modeling
In order to characterize landslide frequency-size distributions and
individuate hazard scenarios and their possible precursors, we investigate a
cellular automaton where the effects of a finite driving rate and the
anisotropy are taken into account. The model is able to reproduce observed
features of landslide events, such as power-law distributions, as
experimentally reported. We analyze the key role of the driving rate and show
that, as it is increased, a crossover from power-law to non power-law behaviors
occurs. Finally, a systematic investigation of the model on varying its
anisotropy factors is performed and the full diagram of its dynamical behaviors
is presented.Comment: 8 pages, 9 figure
Evaluating 5-nitrofurans as trypanocidal agents
The nitroheterocycle nifurtimox, as part of a nifurtimox-eflornithine combination therapy, represents one of a limited number of treatments targeting Trypanosoma brucei, the causative agent of human African trypanosomiasis. The mode of action of this prodrug involves an initial activation reaction catalysed by a type I nitroreductase (NTR), an enzyme found predominantly in prokaryotes, leading to the formation of a cytotoxic unsaturated open chain nitrile metabolite. Here, we evaluate the trypanocidal activity of a library of other 5-nitrofurans against bloodstream form T. brucei as a preliminary step in the identification of additional nitroaromatic compounds that could potentially partner eflornithine. Biochemical screening against purified enzyme revealed that all 5-nitrofurans were effective substrates for TbNTR with the preferred compounds having apparent kcat/KM values approximately 50-fold greater than nifurtimox. For several compounds, in vitro reduction by this nitroreductase yielded products characterized by mass spectroscopy as either unsaturated or saturated open chain nitriles. When tested against bloodstream form T. brucei, many of the derivatives displayed significant growth inhibitory properties with the most potent compounds generating IC50 values around 200 nM. The anti-parasitic activity of the most potent agents was demonstrated to be NTR dependent as parasites having reduced levels of the enzyme displayed resistance to the compounds while parasites over expressing TbNTR showed hypersensitivity. We conclude that other members of the 5-nitrofurans class of nitroheterocycles have potential to treat human African trypanosomiasis perhaps as an alternative partner prodrug to nifurtimox in the next generation of eflornithine-based combinational therapies
Plio-Pleistocene geological evolution of the northern Sicily continental margin (southern Tyrrhenian Sea): new insights from high-resolution, multi-electrode sparker profiles
High-resolution seismic profiles were acquired in the north Sicily offshore region with an innovative, multi-tip sparker array which lacks ringing and has a base frequency around 600 Hz. The new data, combined
with published data, suggest that intra-slope and extensional basins formed as a consequence of the late
Miocene (?)–early Pliocene shortening and thrusting,
and the middle (?)–late Pliocene continental rifting affecting the internal side of the Sicilian-Maghrebian chain. Early (?) Pleistocene to Holocene high-amplitude
and high-frequency sea-level changes resulted in repeated
sub-aerial exposure and flooding of the shelf, and the deposition of cyclically arranged hemipelagic and shelf sediments. An uplift of the shelf could explain the non-preservation of the transgressive and of the lowstand wedge systems tracts in the oldest sequences
Modal analysis of an isolated nonlinear response mode using the Nyquist circle properties:Numerical case
Measuring fracture toughness of coatings using FIB-machined microbeams
Measuring the toughness of brittle coatings has always been a difficult task. Coatings are often too thin to easily prepare a freestanding sample of a defined geometry to use standard toughness measuring techniques. Using standard indentation techniques gives results influenced by the effect of the substrate. A new technique for measuring the toughness of coatings is described here. A precracked micro-beam was produced using focused ion beam (FIB) machining, then imaged and loaded to fracture using a nanoindenter. © 2005 Materials Research Society
Sympathovagal balance and 1-h postload plasma glucose in normoglucose tolerant hypertensive patients.
AIMS:
Normoglucose tolerant (NGT) subjects with a 1-h postload plasma glucose (PLPG) value ≥155 mg/dL have an increased risk of type-2 diabetes and subclinical organ damage. Heart rate variability (HRV) reflects cardiac autonomic balance, frequently impaired in course of diabetes. At this time, no data support the association between 1-h PLPG and HRV; thus, we investigated the possible association between 1-h PLPG and HRV.
METHODS:
We enrolled 92 never-treated hypertensive subjects (56 women, 36 men), aged 55 ± 9.8 years. During OGTT, the patients underwent electrocardiographic recordings to evaluate HRV in the time domain (SDNN). Insulin sensitivity was assessed by Matsuda index.
RESULTS:
Among participants, 56 were NGT, 20 had impaired glucose tolerance (IGT), and 16 had type-2 diabetes. According to the 1-h PLPG cutoff point of 155 mg/dL, we divided NGT subjects into: NGT < 155 (n = 38) and NGT ≥ 155 (n = 18). Glucose tolerance status was associated with a significant (P < 0.0001) increase in PLPG and insulin and the reduction in Matsuda index. In all groups, the SDNN values significantly (P < 0.0001) decreased during the first hour of OGTT. A complete recovery in NGT groups was observed at the end of the second hour; in IGT and type-2 diabetes, SDNN remained significantly lower with respect to baseline values. At multiple regression analysis, Matsuda index resulted in the only determinant of SDNN modification, explaining the 12.3 % of its variability.
CONCLUSIONS:
Our data demonstrate that during OGTT, sympathovagal balance is acutely affected by both glucose and insulin modifications. Particularly, NGT ≥ 155 subjects behave in the same way of IGT and type-2 diabetes patients
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