Thermal conduction and particle transport in strong MHD turbulence, with application to galaxy-cluster plasmas

We investigate field-line separation in strong MHD turbulence analytically and with direct numerical simulations. We find that in the static-magnetic-field approximation the thermal conductivity in galaxy clusters is reduced by a factor of about 5-10 relative to the Spitzer thermal conductivity of a non-magnetized plasma. We also estimate how the thermal conductivity would be affected by efficient turbulent resistivity.Comment: Major revision: higher resolution simulations lead to significantly different conclusions. 26 pages, 10 figure

Acceleration of energetic particles by large-scale compressible magnetohydrodynamic turbulence

Fast particles diffusing along magnetic field lines in a turbulent plasma can diffuse through and then return to the same eddy many times before the eddy is randomized in the turbulent flow. This leads to an enhancement of particle acceleration by large-scale compressible turbulence relative to previous estimates in which isotropic particle diffusion is assumed.Comment: 13 pages, 3 figures, accepted for publication in Ap

Measuring Accuracy of Triples in Knowledge Graphs

An increasing amount of large-scale knowledge graphs have been constructed in recent years. Those graphs are often created from text-based extraction, which could be very noisy. So far, cleaning knowledge graphs are often carried out by human experts and thus very inefficient. It is necessary to explore automatic methods for identifying and eliminating erroneous information. In order to achieve this, previous approaches primarily rely on internal information i.e. the knowledge graph itself. In this paper, we introduce an automatic approach, Triples Accuracy Assessment (TAA), for validating RDF triples (source triples) in a knowledge graph by finding consensus of matched triples (among target triples) from other knowledge graphs. TAA uses knowledge graph interlinks to find identical resources and apply different matching methods between the predicates of source triples and target triples. Then based on the matched triples, TAA calculates a confidence score to indicate the correctness of a source triple. In addition, we present an evaluation of our approach using the FactBench dataset for fact validation. Our findings show promising results for distinguishing between correct and wrong triples

Cardiac Screening of Young Athletes: a Practical Approach to Sudden Cardiac Death Prevention.

PURPOSE OF REVIEW: We aim to report on the current status of cardiovascular screening of athletes worldwide and review the up-to-date evidence for its efficacy in reducing sudden cardiac death in young athletes. RECENT FINDINGS: A large proportion of sudden cardiac death in young individuals and athletes occurs during rest with sudden arrhythmic death syndrome being recognised as the leading cause. The international recommendations for ECG interpretation have reduced the false-positive ECG rate to 3% and reduced the cost of screening by 25% without compromising the sensitivity to identify serious disease. There are some quality control issues that have been recently identified including the necessity for further training to guide physicians involved in screening young athletes. Improvements in our understanding of young sudden cardiac death and ECG interpretation guideline modification to further differentiate physiological ECG patterns from those that may represent underlying disease have significantly improved the efficacy of screening to levels that may make screening more attractive and feasible to sporting organisations as a complementary strategy to increased availability of automated external defibrillators to reduce the overall burden of young sudden cardiac death

Resonance Broadening and Heating of Charged Particles in Magnetohydrodynamic Turbulence

The heating, acceleration, and pitch-angle scattering of charged particles by MHD turbulence are important in a wide range of astrophysical environments, including the solar wind, accreting black holes, and galaxy clusters. We simulate the interaction of high-gyrofrequency test particles with fully dynamical simulations of subsonic MHD turbulence, focusing on the parameter regime with beta ~ 1, where beta is the ratio of gas to magnetic pressure. We use the simulation results to calibrate analytical expressions for test particle velocity-space diffusion coefficients and provide simple fits that can be used in other work. The test particle velocity diffusion in our simulations is due to a combination of two processes: interactions between particles and magnetic compressions in the turbulence (as in linear transit-time damping; TTD) and what we refer to as Fermi Type-B (FTB) interactions, in which charged particles moving on field lines may be thought of as beads spiralling around moving wires. We show that test particle heating rates are consistent with a TTD resonance which is broadened according to a decorrelation prescription that is Gaussian in time. TTD dominates the heating for v_s >> v_A (e.g. electrons), where v_s is the thermal speed of species s and v_A is the Alfven speed, while FTB dominates for v_s << v_A (e.g. minor ions). Proton heating rates for beta ~ 1 are comparable to the turbulent cascade rate. Finally, we show that velocity diffusion of collisionless, large gyrofrequency particles due to large-scale MHD turbulence does not produce a power-law distribution function.Comment: 20 pages, 15 figures; accepted by The Astrophysical Journal; added clarifying appendices, but no major changes to result

Using Synthetic Spacecraft Data to Interpret Compressible Fluctuations in Solar Wind Turbulence

Kinetic plasma theory is used to generate synthetic spacecraft data to analyze and interpret the compressible fluctuations in the inertial range of solar wind turbulence. The kinetic counterparts of the three familiar linear MHD wave modes---the fast, Alfven, and slow waves---are identified and the properties of the density-parallel magnetic field correlation for these kinetic wave modes is presented. The construction of synthetic spacecraft data, based on the quasi-linear premise---that some characteristics of magnetized plasma turbulence can be usefully modeled as a collection of randomly phased, linear wave modes---is described in detail. Theoretical predictions of the density-parallel magnetic field correlation based on MHD and Vlasov-Maxwell linear eigenfunctions are presented and compared to the observational determination of this correlation based on 10 years of Wind spacecraft data. It is demonstrated that MHD theory is inadequate to describe the compressible turbulent fluctuations and that the observed density-parallel magnetic field correlation is consistent with a statistically negligible kinetic fast wave energy contribution for the large sample used in this study. A model of the solar wind inertial range fluctuations is proposed comprised of a mixture of a critically balanced distribution of incompressible Alfvenic fluctuations and a critically balanced or more anisotropic than critical balance distribution of compressible slow wave fluctuations. These results imply that there is little or no transfer of large scale turbulent energy through the inertial range down to whistler waves at small scales.Comment: Accepted to Astrophysical Journal. 28 pages, 7 figure

MEPicides: Potent antimalarial prodrugs targeting isoprenoid biosynthesis

AbstractThe emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis, including the clinically validated target, deoxyxylulose phosphate reductoisomerase (Dxr). Here we describe RCB-185, a lipophilic prodrug with nanomolar activity against asexual parasites. Growth of P. falciparum treated with RCB-185 was rescued by isoprenoid precursor supplementation, and treatment substantially reduced metabolite levels downstream of the Dxr enzyme. In addition, parasites that produced higher levels of the Dxr substrate were resistant to RCB-185. Notably, environmental isolates resistant to current therapies remained sensitive to RCB-185, the compound effectively treated sexually-committed parasites, and was both safe and efficacious in malaria-infected mice. Collectively, our data demonstrate that RCB-185 potently and selectively inhibits Dxr in P. falciparum, and represents a promising lead compound for further drug development.</jats:p

Statistical anisotropy of magnetohydrodynamic turbulence

Direct numerical simulations of decaying and forced magnetohydrodynamic (MHD) turbulence without and with mean magnetic field are analyzed by higher-order two-point statistics. The turbulence exhibits statistical anisotropy with respect to the direction of the local magnetic field even in the case of global isotropy. A mean magnetic field reduces the parallel-field dynamics while in the perpendicular direction a gradual transition towards two-dimensional MHD turbulence is observed with $k^{-3/2}$ inertial-range scaling of the perpendicular energy spectrum. An intermittency model based on the Log-Poisson approach, $\zeta_p=p/g^2 +1 -(1/g)^{p/g}$, is able to describe the observed structure function scalings.Comment: 4 pages, 3 figures. To appear in Phys.Rev.