Helium exhaust experiments on JET with Type I ELMs in H-mode and with type III ELMs in ITB discharges

An analysis of helium exhaust experiments on JET in the MkII-GB divertor configuration is presented. Helium is pumped by applying an argon frost layer on the divertor cryo pump. Measurement of the helium retention time, tau(He)(*),, is performed in two ways: by the introduction of helium in gas puffs and measurement of the subsequent decay time constant of the helium content, tau(He)(d*); and by helium beam injection and measurement of the helium replacement time, tau(He)(r*). In ELMy H-mode, with plasma configuration optimized for pumping, tau(He)(d*) approximate to 7.2 x tau(E)(th) is achieved, where tau(E)(th) is the thermal energy replacement time. For quasi-steady internal transport barrier (ITB) discharges, the achieved tau(He)(r*) approximate to 4.1 x tau(E)(th) is significantly lower. The achieved helium recycling coefficient, confirmed by an independent measurement to be R-eff approximate to 0.91, is the same in both scenarios. None of the discharges are dominated by core confinement. The difference in tau(He)(*)/tau(E)(th) is instead due to the confinement properties of the edge plasma, which is characterized by Type I ELMs for the H-mode discharges studied, and Type III ELMs for the quasi-steady ITB discharges. This difference is quantified by an independent measurement of the ratio of the helium replacement time with a helium edge source to the energy confinement time

Ethnomedicine in healthcare systems of the world: a Semester at Sea pilot survey in 11 countries

An understanding and appreciation for the varied healthcare systems in use throughout the world are increasingly vital for medical personnel as patient populations are now composed of ethnically diverse people with wide-ranging belief systems. While not a statistically valid survey, this pilot study gives a global overview of healthcare differences around the world. A pilot study of 459 individuals from 11 different countries around the world was administered by 33 students in the upper division course, People, Pathology, and World Medicine from Semester at Sea, Fall 2007, to ascertain trends in healthcare therapies. Open-ended surveys were conducted in English, through an interpreter, or in the native language. Western hospital use ranked highly for all countries, while ethnomedical therapies were utilized to a lesser degree. Among the findings, mainland China exhibited the greatest overall percentage of ethnomedical therapies, while the island of Hong Kong, the largest use of Western hospitals. The figures and trends from the surveys suggest the importance of understanding diverse cultural healthcare beliefs when treating individuals of different ethnic backgrounds. The study also revealed the increasingly complex and multisystem-based medical treatments being used internationally

Natural parenting : back to basics in infant care

Peer reviewe

Site directed mutagenesis as a tool to understand the catalytic mechanism of human cytidine deaminase.

Cytidine deaminase (CDA), is one of the enzymes involved in the pyrimidine salvage pathways, which catalyzes the formation of uridine and deoxyuridine by the hydrolytic deamination of cytidine and deoxycytidine, respectively. Human CDA is a tetrameric enzyme of identical 15 kDa subunits, each containing an essential zinc atom in the active site. The substrate binds to each active site independently and the cooperativity between subunits has not been reported. CDA is able to recognize as substrates some antitumor and antiviral cytidine analogs rendering them pharmacologically inactive. In light of the role played by this enzyme, a deep knowledge of CDA active site and mechanism of catalysis is required. Site-directed mutagenesis, associated with molecular modeling studies, may be an important tool to discover the active site structure of an enzyme and consequently its mechanism of action. In this review are summarized the site-directed mutagenesis experiments performed on human CDA: through these studies it was possible to understand the role exerted by specific amino acid residues in CDA active site and in the contacts between subunits. The obtained results may open a way for designing new cytidine based drugs or more potent CDA inhibitors

A new indirect measurement method of the electron temperature for the Protosphera's pinch plasma

This article presents a new method for estimating the electron temperature of the Protosphera's screw pinch. The temperature radial profile is obtained by a self-consistent modeling of a 1D MHD equilibrium along with a 0D power balance of the plasma column, given measurements and estimates of the axial pinch plasma current, of the plasma rotational frequency and, at the equatorial plane, of the electron density radial profile, of the edge poloidal magnetic field, of the edge electron temperature and of the neutrals pressure in the vacuum vessel. The plasma is considered in equilibrium with its neutral phase and in constant rotation. A MATLAB code has been developed with the aim of estimating the MHD radial equilibrium profiles, the thermodynamic plasma state and the neutrals profile. The numerical estimates are compared with available experimental data showing a good agreement.Comment: 4 pages, 6 figures, 1 table, research presented to the "6th ICFDT

A new indirect measurement method of the electron temperature for the Proto-sphera's pinch plasma

This article presents a new method for estimating the electron temperature of the Proto-sphera's screw pinch. The temperature radial profile is obtained by a self-consistent modeling of a 1D MHD equilibrium along with a 0D power balance of the plasma column, given measurements and estimates of the axial pinch plasma current, of the plasma rotational frequency and, at the equatorial plane, of the electron density radial profile, of the edge poloidal magnetic field, of the edge electron temperature and of the neutrals pressure in the vacuum vessel. The plasma is considered in equilibrium with its neutral phase and in constant rotation. A MATLAB code has been developed with the aim of estimating the MHD radial equilibrium profiles, the thermodynamic plasma state and the neutrals profile. The numerical estimates are compared with available experimental data showing a good agreement

Push ‘o ver: in situ pushover tests on as built and strengthened existing brickwork constructions

In the last decades several experimental tests were performed to analyse the seismic capacity of unreinforced masonry, mostly involving small size structural elements or small-scale building models, not accounting for the actual complexity of existing constructions. This paper illustrates experimental pushover tests on two very similar portions of an existing masonry building. The first portion was tested as built, while the second one was tested after a strengthening intervention with Composite Reinforced Mortar (CRM) system with Glass Fiber Reinforced Polymer (GFRP) components. The retrofit consisted in the application of a reinforced plaster on both sides of the walls of the first storey and on the external side only of the second storey, a solution that preserves the continuity of use. Comparisons between the experimental response of the two portions as well as the observed behaviour of the intervention at the first storey (both wall sides) and second storey (only outer side) provide very interesting insights and preliminary information on the degree of upgrading, essential steps to support the assessment of seismic vulnerability reduction

Push ‘o ver. In situ pushover tests on as built and strengthened existing brickwork constructions

In the last decades several experimental tests were performed to analyse the seismic capacity of unreinforced masonry, mostly involving small size structural elements or small-scale building models, not accounting for the actual complexity of existing constructions. This paper illustrates experimental pushover tests on two very similar portions of an existing masonry building. The first portion was tested as built, while the second one was tested after a strengthening intervention with Composite Reinforced Mortar (CRM) system with Glass Fiber Reinforced Polymer (GFRP) components. The retrofit consisted in the application of a reinforced plaster on both sides of the walls of the first storey and on the external side only of the second storey, a solution that preserves the continuity of use. Comparisons between the experimental response of the two portions as well as the observed behaviour of the intervention at the first storey (both wall sides) and second storey (only outer side) provide very interesting insights and preliminary information on the degree of upgrading, essential steps to support the assessment of seismic vulnerability reduction

Investigating the Performance of a Degraded Prestressed Concrete Box Girder Half-joint Bridge in the Spirit of the Italian Guidelines

The paper investigates a paired pre-stressed box-girder concrete bridge, according to the framework suggested by the new Italian Guidelines for the risk assessment of existing bridges. The bridges, selected as case study within the research agreement signed by the FABRE Consortium and ANAS S.p.A. for first applications of the Italian Guidelines, present significant age-related degradation phenomena known to the Administrator, who decided for the bridges demolition and reconstruction. Visual inspections confirmed defects in the pre-stressing system, a permanent deflection of the deck, and cracks at half-joints, possibly due to pre-stressing loss and creep effects triggered by the poor quality of concrete. Also, preliminary safety verifications revealed not to meet code requirements in most cross-sections. Consequently, the most degraded bridge was closed. From March 2022, experimental campaigns have been performed by the FABRE Consortium and ANAS for improving their experience on the behaviour of old pre-stressed concrete bridges, as well as to control possible performance loss of the open bridge, sustaining the overall route traffic. The paper summarises these activities and presents some possible future investigations to be carried out before bridge demolition