583 research outputs found

    Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites

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    A 43-year-old man had a peritoneovenous shunt inserted for the treatment of chylous ascites secondary to myelofibrosis. Despite being on anticoagulation for superior mesenteric vein thrombosis, he developed shunt dysfunction within two weeks of insertion. Superior venacavography showed multiple filling defects in the right axillary vein, no filling of the right brachiocephalic and right subclavian vein, and thrombotic occlusion of the internal jugular veins bilaterally. The shunt was removed 11 days after insertion, and there was extensive thrombosis of the venous end of the shunt and the compressible pump chamber. Shunt thrombosis is known to occur but remains a rare complication, with 87% of such obstructions being due to a thrombus at the tip of the venous end of the shunt. Extensive thrombosis of the shunt (as in the present case) is very rare

    A 2km-size asteroid challenging the rubble-pile spin barrier – A case for cohesion

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    The rubble pile spin barrier is an upper limit on the rotation rate of asteroids larger than ~200-300. m. Among thousands of asteroids with diameters larger than ~300. m, only a handful of asteroids are known to rotate faster than 2.0. h, all are in the sub-km range (≤0.6. km). Here we present photometric measurements suggesting that (60716) 2000 GD65, an S-complex, inner-main belt asteroid with a relatively large diameter of 2.3-0.7+0.6km, completes one rotation in 1.9529. ±. 0.0002. h. Its unique diameter and rotation period allow us to examine scenarios about asteroid internal structure and evolution: a rubble pile bound only by gravity; a rubble-pile with strong cohesion; a monolithic structure; an asteroid experiencing mass shedding; an asteroid experiencing YORP spin-up/down; and an asteroid with a unique octahedron shape results with a four-peak lightcurve and a 3.9. h period. We find that the most likely scenario includes a lunar-like cohesion that can prevent (60716) 2000 GD65 from disrupting without requiring a monolithic structure or a unique shape. Due to the uniqueness of (60716) 2000 GD65, we suggest that most asteroids typically have smaller cohesion than that of lunar regolith. Keywords: Asteroids; Asteroids, rotation; Rotational dynamics; PhotometryUnited States. National Aeronautics and Space Administration (Grant NNX12AL26G

    Conditional Allocation of Control Rights in Venture Capital Finance

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    When a young entrepreneurial firm matures, it is often necessary to replace the founding entrepreneur by a professional manager. This replacement decision can be affected by the private benefits of control enjoyed by the entrepreneur which gives rise to a conflict of interest between the entrepreneur and the venture capitalist. We show that a combination of convertible securities and contingent control rights can be used to resolve this conflict efficiently. This contractual arrangement is frequently observed in venture capital finance

    Confronting Reward Model Overoptimization with Constrained RLHF

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    Large language models are typically aligned with human preferences by optimizing reward models\textit{reward models} (RMs) fitted to human feedback. However, human preferences are multi-faceted, and it is increasingly common to derive reward from a composition of simpler reward models which each capture a different aspect of language quality. This itself presents a challenge, as it is difficult to appropriately weight these component RMs when combining them. Compounding this difficulty, because any RM is only a proxy for human evaluation, this process is vulnerable to overoptimization\textit{overoptimization}, wherein past a certain point, accumulating higher reward is associated with worse human ratings. In this paper, we perform, to our knowledge, the first study on overoptimization in composite RMs, showing that correlation between component RMs has a significant effect on the locations of these points. We then introduce an approach to solve this issue using constrained reinforcement learning as a means of preventing the agent from exceeding each RM's threshold of usefulness. Our method addresses the problem of weighting component RMs by learning dynamic weights, naturally expressed by Lagrange multipliers. As a result, each RM stays within the range at which it is an effective proxy, improving evaluation performance. Finally, we introduce an adaptive method using gradient-free optimization to identify and optimize towards these points during a single run

    DISCOVERY AND EARLY MULTI-WAVELENGTH MEASUREMENTS OF THE ENERGETIC TYPE IC SUPERNOVA PTF12GZK: A MASSIVE-STAR EXPLOSION IN A DWARF HOST GALAXY

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    We present the discovery and extensive early-time observations of the Type Ic supernova (SN) PTF12gzk. Our light curves show a rise of 0.8 mag within 2.5 hr. Power-law fits (f(t)∝(t – t 0) n ) to these data constrain the explosion date to within one day. We cannot rule out a quadratic fireball model, but higher values of n are possible as well for larger areas in the fit parameter space. Our bolometric light curve and a dense spectral sequence are used to estimate the physical parameters of the exploding star and of the explosion. We show that the photometric evolution of PTF12gzk is slower than that of most SNe Ic. The high ejecta expansion velocities we measure (~30, 000 km s–1 derived from line minima four days after explosion) are similar to the observed velocities of broad-lined SNe Ic associated with gamma-ray bursts (GRBs) rather than to normal SN Ic velocities. Yet, this SN does not show the persistent broad lines that are typical of broad-lined SNe Ic. The host-galaxy characteristics are also consistent with GRB-SN hosts, and not with normal SN Ic hosts. By comparison with the spectroscopically similar SN 2004aw, we suggest that the observed properties of PTF12gzk indicate an initial progenitor mass of 25-35 M ☉ and a large ((5-10) × 1051 erg) kinetic energy, the later being close to the regime of GRB-SN properties
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