78 research outputs found

    Italy

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    CHAPTER 26. Selenium in Autoimmune Thyroiditis

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    Design-based corporate entrepreneurship: the case of McDonald’s service innovation

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    In the era of fierce competition and thirst for innovation, the use of the design thinking (DT) practice as a mechanism for corporate entrepreneurship (CE) is increasing. If applied in large networked organisations, e.g. multinational companies (MNCs), DT can help to adapt to local customers’ needs and develop strategic CE orientation. While there is vast and ambiguous literature exploring the concept of DT and its enactment in practice with various purposes, little attention is paid to the diffusion of DT in pluralistic institutional contexts with the purpose of fostering CE. Based on an extensive literature review and supported by a single case study of McDonald’s Service Innovation, this paper investigates the phenomenon of the design-based CE in large organisations and describes its developmental pattern on a global scale. The paper presents three main findings. First, it develops the model of the design-based CE and outlines its main characteristics. Second, it proposes the framework that explains the development of the design-based CE on a corporate level. Third, the paper puts focus on the diffusion of the design-based CE in different subsidiaries of a MNC

    Introduction

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    Hyperosmolar nonketotic coma at the onset of Type I diabetes in a child

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    Hyperosmolar nonketotic coma at the onset of type I diabetes in a child.

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    A 12 yr-old child without any past medical history of diseases was admitted to hospital for sopor and polyuria. At admission he was markedly dehydrated. Blood glucose was 72 mmol/l, sodium 154 mmol/l, osmolarity 381 mOsm/Kg, urinary ketons were negative. He was rehydrated with hypotonic saline and treated with insulin. The osmolality and sodium initially increased to 176 mmol/l and 408 mOsm/Kg respectively and progressively decreased to normal levels. Serum transaminases increased to GOT 336 and GPT 209 U/l in the first days of treatment and normalized after 15 days. The anti-islet antibodies were positive. The non ketotic hyperosmolar coma and Type I diabetes is rare in children but this possibility must be kept in mind especially when some familial or psychological problems are present as in our case
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