Oakleaf: an S locus-linked mutation of Primula vulgaris that affects leaf and flower development

•In Primula vulgaris outcrossing is promoted through reciprocal herkogamy with insect-mediated cross-pollination between pin and thrum form flowers. Development of heteromorphic flowers is coordinated by genes at the S locus. To underpin construction of a genetic map facilitating isolation of these S locus genes, we have characterised Oakleaf, a novel S locus-linked mutant phenotype. •We combine phenotypic observation of flower and leaf development, with classical genetic analysis and next-generation sequencing to address the molecular basis of Oakleaf. •Oakleaf is a dominant mutation that affects both leaf and flower development; plants produce distinctive lobed leaves, with occasional ectopic meristems on the veins. This phenotype is reminiscent of overexpression of Class I KNOX-homeodomain transcription factors. We describe the structure and expression of all eight P. vulgaris PvKNOX genes in both wild-type and Oakleaf plants, and present comparative transcriptome analysis of leaves and flowers from Oakleaf and wild-type plants. •Oakleaf provides a new phenotypic marker for genetic analysis of the Primula S locus. We show that none of the Class I PvKNOX genes are strongly upregulated in Oakleaf leaves and flowers, and identify cohorts of 507 upregulated and 314 downregulated genes in the Oakleaf mutant

High Efficiency Megawatt Motor Preliminary Design

The High Efficiency Megawatt Motor (HEMM) is being designed to meet the needs of Electrified Aircraft Propulsion (EAP). A preliminary design has been completed and risk reduction activities are being conducted in three key areas: cryogenic cooler design, superconducting rotor coil design and manufacturing, and stator thermal management. The key objective of HEMM is to establish a motor technology which simultaneously attains high specific power (>16kW/kg ratio to electromagnetic weight) and high efficiency (>98%) by judicious application of high temperature superconducting wire and integrated thermal management. Another important feature is to achieve the performance goals with an eye to aircraft integration constraints. An electromagnetic analysis was performed which shows that the proposed HEMM design meets the performance objectives if key current capability and mechanical constraints are achieved. The risk reduction activities are the first assessment of the key design features. The HEMM technology could be applied to a range of aircraft types that require megawatt level electrical power

Psychotropic drug concentrations and clinical outcomes in children and adolescents: a systematic review

Introduction: The use of psychotropic drugs in children and adolescents is widespread but associated with suboptimal treatment effects. Therapeutic drug monitoring (TDM) can improve safety of psychotropic drugs in children and adolescents but is not routinely performed. A major reason is that the relationship between drug concentrations and effects is not well known. Areas covered: This systematic review evaluated studies assessing the relationship between psychotropic drug concentrations and clinical outcomes in children and adolescents, including antipsychotics, psychostimulants, alpha-agonists, antidepressants, and mood-stabilizers. PRISMA guidelines were used and a quality assessment of the retrieved studies was performed. Sixty-seven eligible studies involving 24 psychotropic drugs were identified from 9,298 records. The findings were generally heterogeneous and the majority of all retrieved studies were not of sufficient quality. For 11 psychotropic drugs, a relationship between drug concentrations and side-effects and/or effectiveness was evidenced in reasonably reported and executed studies, but these findings were barely replicated. Expert opinion: In order to better support routine TDM in child- and adolescent psychiatry, future work must improve in aspects of study design, execution and reporting to demonstrate drug concentration-effect relationships. The quality criteria proposed in this work can guide future TDM research. Systematic review protocol and registration PROSPERO CRD42018084159

Analysis of Dehydration and Strength in Elite Badminton Players

Background: The negative effects of dehydration on aerobic activities are well established. However, it is unknown how dehydration affects intermittent sports performance. The purpose of this study was to identify the level of dehydration in elite badminton players and its relation to muscle strength and power production. Methodology: Seventy matches from the National Spanish badminton championship were analyzed (46 men?s singles and 24 women?s singles). Before and after each match, jump height and power production were determined during a countermovement jump on a force platform. Participants? body weight and a urine sample were also obtained before and after each match. The amount of liquid that the players drank during the match was also calculated by weighing their individual drinking bottles. Results and Discussion: Sweat rate during the game was 1.1460.46 l/h in men and 1.0260.64 l/h in women. The players rehydrated at a rate of 1.1060.55 l/h and 1.0160.44 l/h in the male and female groups respectively. Thus, the dehydration attained during the game was only 0.3760.50% in men and 0.3260.83% in women. No differences were found in any of the parameters analyzed during the vertical jump (men: from 31.8265.29 to 32.9064.49 W/kg; p.0.05, women: from 26.3664.73 to 27.2564.44 W/kg; p.0.05). Post-exercise urine samples revealed proteinuria (60.9% of cases in men and 66.7% in women), leukocyturia (men = 43.5% and women = 50.0%) and erythrocyturia (men = 50.0% and women = 21.7%). Conclusions: Despite a moderate sweat rate, badminton players adequately hydrated during a game and thus the dehydration attained was low. The badminton match did not cause muscle fatigue but it significantly increased the prevalence of proteinuria, leukocyturia and erythrocyturia

The Anatomy of Memory Politics: A Formalist Analysis of Tate Britain’s ‘Artist and Empire’ and the Struggle over Britain’s Imperial Past

In this paper, I propose a new approach for understanding the meaning of memory politics, which draws upon the archetypal literary criticism of Northrop Frye. I suggest that the four archetypes elaborated by Frye—comedy, romance, tragedy, and satire—can be used as a heuristic device for interpreting the contested historical narratives that are associated with the politics of memory. I illustrate this approach through a case-study of Artists and Empire: Facing Britain’s Imperial Past, an exhibition held at Tate Britain in 2016, amidst increasing contestation over the meaning of the British Empire. In sum, I find that the exhibit narrated Britain’s imperial past as a comedy, in which a key theme was the progressive cultural mixing of the British and the people they colonized. To conclude, I discuss the implications of such a narrative for constructing an inclusive, postcolonial British identity. As an alternative, I draw on Aristotle to suggest that a tragic narrative would have been more propitious

Cognoscite lilia agri quomodo crescant.

On spine: Icones. Florum.No text. Early issue before text. Believed to be first printing of the plates and the earliest flower engravings by de Passe, probably while he was living in Cologne. Other editions have title: Hortus floridus.120 numbered engravings of flowers and fruits, with insects, animals and birds.Engraved t.p. included in plates.Mary Ann Beinecke Decorative Art Collection. Sterling and Francine Clark Art Institute Library.Mode of access: Internet.With this is bound Florae deae, [16--?

HEGEMONÍA CULTURAL Y VALORES EN JALISCO

En el campo de las relaciones exte­riores de México, en la época actual sobresalen los estudios sobre el Tra­tado de Libre Comercio (TLC), que se enfocan principalmente a cuestio­nes económicas: comercio, genera­ción de empleos, retos de las indus­trias pequeñas y medianas, proble­mas ambientales. Sin embargo, se han reali­zado pocos análisis empíricos sobre el impacto cultural y político de la integración económica. Sin menos­preciar la importancia del aspecto económico, una parte fundamental en el futuro del tratado y las relacio­nes entre países vecinos depende de los efectos culturales y políticos

Les abus du mariage, ou sont clairement representez les subtilitez deshonnestes, tant des femmes que des hommes, dont ils usent pour se tromper l'un l'autre. A cecy sont adjoustez quelques enseignemens pour corriger tels abus. Misbruick des houwelycx, waer in klaerlijck word uitgebeeldt de boosheden en loosheden zo wel tusschen mannen als vrouwen gepleeght, om malkander behendigh te bedriegen. Hier zijn bygevoeght eenige nutte en noodige leeringh, streckende tot verbeteringe der hedensdaeghsche bedorven huyshoudinge. The mistake off matrimonij, wherin is clearely set out the shamefull craftinesse as well by men, as women, pleading one against an other of their shamefull deceitfulnesse. Here is also by joyned some learned instructions to the amendement and reproouing of that filthinesse.

Signatures: A-G⁴ H² I⁴ [superscript chi]I⁴ (...)⁴ (...)(...)². First 3 leaves of gathering I signed I2, I3, I4.Added engraved t.p. Twenty-five pairs of portrait-like engravings within oval borders, numbered 1-50. They are printed on rectos, with Dutch verses beneath and additional verses in French, Dutch & English on facing versos. Woodcut music for the song "Vrolick wagen-liedt," [superscript chi]I2r. Full-page etched ill. for "Waghe-liedt," I1v.Mode of access: Internet.Bookplates or labels of Huth ("EX MUSÆO HVTHII"), Edouard Rahir, John Saks, John Landwehr.Binding: 19th-century black goatskin, signed by W. Pratt. Tooled in gilt, edges gilt. Now in modern chemise & slipcase

Nassovischen oraignien-boom : daer by ghevoecht, de conterfeytsels der voornaemster helden, die vvt desen stam ghesproten zijn, die hen (in tyden van oorlogen) in dese Vrye-landen ghebruyckt hebben = Malus aurantius Nassovicus : continens simulachra heroum ex illustrissi stirpe Nassovica or. quorum consilio et armis libertas provinciar. confoed. Belgij hactenus conservata et defensa est.

Latin parallel title from circular reserve in engraved t.p. vignette. The 14 engraved ports. of members of the House of Nassau are placed on rectos of leaves, with biographical letterpress on facing versos. The 5th port. is signed with Crispin van de Passe's monogram, who engraved the entire series; see Hollstein. Folded table at end is genealogy of House of Nassau.Hollstein Dutch & Flemish ;Mode of access: Internet.On verso of last port. is 12-line inscription in Dutch concerning Admiral Tromp. It is signed by F.L. Koech.Centered on front pastedown is bookplate of F.C. Koch of Rotterdam, signed PR. Koch's printed label is in the upper left corner, John Landwehr's in the lower left.Binding: modern goatskin. Boards tooled in gilt with double frames. Fleurons, title & date in gilt on spine. The title reads: BUGHELIUS [Arend van Buchell?] / NASSOVISCHEN / ORAIGNIEN / BOOM. Page edges gilt